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Protein
Submitted name:

Receptor tyrosine-protein kinase erbB-2

Gene

ERBB2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Receptor tyrosine-protein kinase erbB-2Imported
Gene namesi
Name:ERBB2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:3430. ERBB2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000141736.

PTM / Processingi

Proteomic databases

MaxQBiF5H1T4.
PaxDbiF5H1T4.
PeptideAtlasiF5H1T4.
PRIDEiF5H1T4.

Expressioni

Gene expression databases

BgeeiENSG00000141736.
ExpressionAtlasiF5H1T4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000269571.

Structurei

3D structure databases

ProteinModelPortaliF5H1T4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 142Recep_L_domainInterPro annotationAdd BLAST121
Domaini160 – 313Furin-likeInterPro annotationAdd BLAST154
Domaini336 – 455Recep_L_domainInterPro annotationAdd BLAST120
Domaini481 – 602GF_recep_IVInterPro annotationAdd BLAST122

Phylogenomic databases

eggNOGiKOG1025. Eukaryota.
ENOG410XNSR. LUCA.
GeneTreeiENSGT00760000118799.

Family and domain databases

Gene3Di3.80.20.20. 2 hits.
InterProiIPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR032778. GF_recep_IV.
IPR009030. Growth_fac_rcpt_.
IPR032675. L_dom-like.
IPR000494. Rcpt_L-dom.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF14843. GF_recep_IV. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
SMARTiSM00261. FU. 3 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF57184. SSF57184. 2 hits.

Sequencei

Sequence statusi: Complete.

F5H1T4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLRLPASPE THLDMLRHLY QGCQVVQGNL ELTYLPTNAS LSFLQDIQEV
60 70 80 90 100
QGYVLIAHNQ VRQVPLQRLR IVRGTQLFED NYALAVLDNG DPLNNTTPVT
110 120 130 140 150
GASPGGLREL QLRSLTEILK GGVLIQRNPQ LCYQDTILWK DIFHKNNQLA
160 170 180 190 200
LTLIDTNRSR ACHPCSPMCK GSRCWGESSE DCQSLTRTVC AGGCARCKGP
210 220 230 240 250
LPTDCCHEQC AAGCTGPKHS DCLACLHFNH SGICELHCPA LVTYNTDTFE
260 270 280 290 300
SMPNPEGRYT FGASCVTACP YNYLSTDVGS CTLVCPLHNQ EVTAEDGTQR
310 320 330 340 350
CEKCSKPCAR VCYGLGMEHL REVRAVTSAN IQEFAGCKKI FGSLAFLPES
360 370 380 390 400
FDGDPASNTA PLQPEQLQVF ETLEEITGYL YISAWPDSLP DLSVFQNLQV
410 420 430 440 450
IRGRILHNGA YSLTLQGLGI SWLGLRSLRE LGSGLALIHH NTHLCFVHTV
460 470 480 490 500
PWDQLFRNPH QALLHTANRP EDECVGEGLA CHQLCARGHC WGPGPTQCVN
510 520 530 540 550
CSQFLRGQEC VEECRVLQGL PREYVNARHC LPCHPECQPQ NGSVTCFGPE
560 570 580 590 600
ADQCVACAHY KDPPFCVARC PSGVKPDLSY MPIWKFPDEE GACQPCPINC

THS
Length:603
Mass (Da):66,543
Last modified:June 28, 2011 - v1
Checksum:iE9E69D9E0052A525
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079199 Genomic DNA. No translation available.
AC087491 Genomic DNA. No translation available.
RefSeqiNP_001276867.1. NM_001289938.1.
UniGeneiHs.446352.

Genome annotation databases

EnsembliENST00000578199; ENSP00000462808; ENSG00000141736.
GeneIDi2064.
UCSCiuc002hsl.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079199 Genomic DNA. No translation available.
AC087491 Genomic DNA. No translation available.
RefSeqiNP_001276867.1. NM_001289938.1.
UniGeneiHs.446352.

3D structure databases

ProteinModelPortaliF5H1T4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000269571.

Proteomic databases

MaxQBiF5H1T4.
PaxDbiF5H1T4.
PeptideAtlasiF5H1T4.
PRIDEiF5H1T4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000578199; ENSP00000462808; ENSG00000141736.
GeneIDi2064.
UCSCiuc002hsl.4. human.

Organism-specific databases

CTDi2064.
HGNCiHGNC:3430. ERBB2.
OpenTargetsiENSG00000141736.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1025. Eukaryota.
ENOG410XNSR. LUCA.
GeneTreeiENSGT00760000118799.

Miscellaneous databases

ChiTaRSiERBB2. human.
GenomeRNAii2064.

Gene expression databases

BgeeiENSG00000141736.
ExpressionAtlasiF5H1T4. baseline and differential.

Family and domain databases

Gene3Di3.80.20.20. 2 hits.
InterProiIPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR032778. GF_recep_IV.
IPR009030. Growth_fac_rcpt_.
IPR032675. L_dom-like.
IPR000494. Rcpt_L-dom.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF14843. GF_recep_IV. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
SMARTiSM00261. FU. 3 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF57184. SSF57184. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiF5H1T4_HUMAN
AccessioniPrimary (citable) accession number: F5H1T4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 2, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.