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Protein
Submitted name:

Receptor tyrosine-protein kinase erbB-2

Gene

ERBB2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Receptor tyrosine-protein kinase erbB-2Imported
Gene namesi
Name:ERBB2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141736.13
HGNCiHGNC:3430 ERBB2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000141736

PTM / Processingi

Proteomic databases

MaxQBiF5H1T4
PeptideAtlasiF5H1T4
PRIDEiF5H1T4

Expressioni

Gene expression databases

BgeeiENSG00000141736
ExpressionAtlasiF5H1T4 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF5H1T4
SMRiF5H1T4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 142Recep_L_domainInterPro annotationAdd BLAST121
Domaini160 – 313Furin-likeInterPro annotationAdd BLAST154
Domaini336 – 455Recep_L_domainInterPro annotationAdd BLAST120
Domaini481 – 602GF_recep_IVInterPro annotationAdd BLAST122

Phylogenomic databases

eggNOGiKOG1025 Eukaryota
ENOG410XNSR LUCA
GeneTreeiENSGT00760000118799

Family and domain databases

Gene3Di3.80.20.20, 2 hits
InterProiView protein in InterPro
IPR006211 Furin-like_Cys-rich_dom
IPR006212 Furin_repeat
IPR032778 GF_recep_IV
IPR009030 Growth_fac_rcpt_cys_sf
IPR000494 Rcpt_L-dom
IPR036941 Rcpt_L-dom_sf
PfamiView protein in Pfam
PF00757 Furin-like, 1 hit
PF14843 GF_recep_IV, 1 hit
PF01030 Recep_L_domain, 2 hits
SMARTiView protein in SMART
SM00261 FU, 3 hits
SUPFAMiSSF57184 SSF57184, 2 hits

Sequencei

Sequence statusi: Complete.

F5H1T4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLRLPASPE THLDMLRHLY QGCQVVQGNL ELTYLPTNAS LSFLQDIQEV
60 70 80 90 100
QGYVLIAHNQ VRQVPLQRLR IVRGTQLFED NYALAVLDNG DPLNNTTPVT
110 120 130 140 150
GASPGGLREL QLRSLTEILK GGVLIQRNPQ LCYQDTILWK DIFHKNNQLA
160 170 180 190 200
LTLIDTNRSR ACHPCSPMCK GSRCWGESSE DCQSLTRTVC AGGCARCKGP
210 220 230 240 250
LPTDCCHEQC AAGCTGPKHS DCLACLHFNH SGICELHCPA LVTYNTDTFE
260 270 280 290 300
SMPNPEGRYT FGASCVTACP YNYLSTDVGS CTLVCPLHNQ EVTAEDGTQR
310 320 330 340 350
CEKCSKPCAR VCYGLGMEHL REVRAVTSAN IQEFAGCKKI FGSLAFLPES
360 370 380 390 400
FDGDPASNTA PLQPEQLQVF ETLEEITGYL YISAWPDSLP DLSVFQNLQV
410 420 430 440 450
IRGRILHNGA YSLTLQGLGI SWLGLRSLRE LGSGLALIHH NTHLCFVHTV
460 470 480 490 500
PWDQLFRNPH QALLHTANRP EDECVGEGLA CHQLCARGHC WGPGPTQCVN
510 520 530 540 550
CSQFLRGQEC VEECRVLQGL PREYVNARHC LPCHPECQPQ NGSVTCFGPE
560 570 580 590 600
ADQCVACAHY KDPPFCVARC PSGVKPDLSY MPIWKFPDEE GACQPCPINC

THS
Length:603
Mass (Da):66,543
Last modified:June 28, 2011 - v1
Checksum:iE9E69D9E0052A525
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079199 Genomic DNA No translation available.
AC087491 Genomic DNA No translation available.
RefSeqiNP_001276867.1, NM_001289938.1
UniGeneiHs.446352

Genome annotation databases

EnsembliENST00000578199; ENSP00000462808; ENSG00000141736
GeneIDi2064
UCSCiuc002hsl.4 human

Similar proteinsi

Entry informationi

Entry nameiF5H1T4_HUMAN
AccessioniPrimary (citable) accession number: F5H1T4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: March 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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