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Protein
Submitted name:

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

Gene

GNB3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiF5H100.

Names & Taxonomyi

Protein namesi
Submitted name:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3Imported
Gene namesi
Name:GNB3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:4400. GNB3.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000111664.

PTM / Processingi

Proteomic databases

MaxQBiF5H100.
PaxDbiF5H100.
PeptideAtlasiF5H100.
PRIDEiF5H100.

Expressioni

Gene expression databases

BgeeiENSG00000111664.
ExpressionAtlasiF5H100. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF5H100.
SMRiF5H100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 232WD_REPEATS_REGIONInterPro annotationAdd BLAST182
Repeati51 – 92WDPROSITE-ProRule annotationAdd BLAST42
Repeati139 – 179WDPROSITE-ProRule annotationAdd BLAST41
Repeati180 – 221WDPROSITE-ProRule annotationAdd BLAST42

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 31Sequence analysisAdd BLAST31

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, WD repeatPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0286. Eukaryota.
ENOG410XQUX. LUCA.
GeneTreeiENSGT00760000119239.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR016346. Guanine_nucleotide-bd_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
PANTHERiPTHR19850. PTHR19850. 1 hit.
PfamiView protein in Pfam
PF00400. WD40. 4 hits.
PRINTSiPR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00320. WD40. 4 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Fragment.

F5H100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEMEQLRQE AEQLKKQIAD ARKACADVTL AELVSGLEVV GRVQMRTRRT
60 70 80 90 100
LRGHLAKIYA MHWATDSKLL VSASQDGKLI VWDSYTTNKV HAIPLRSSWV
110 120 130 140 150
MTCAYAPSGN FVACGGLDNM CSIYNLKSRE GNVKVSRELS AHTGYLSCCR
160 170 180 190 200
FLDDNNIVTS SGDTTCALWD IETGQQKTVF VGHTGDCMSL AVSPDFNLFI
210 220 230
SGACDASAKL WDVREGTCRQ TFTGHESDIN AI
Length:232
Mass (Da):25,482
Last modified:September 18, 2013 - v2
Checksum:i88E16B5DB2B12B30
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei232Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47924 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000541978; ENSP00000439753; ENSG00000111664.
UCSCiuc058klt.1. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiF5H100_HUMAN
AccessioniPrimary (citable) accession number: F5H100
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: September 18, 2013
Last modified: July 5, 2017
This is version 44 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported