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Protein
Submitted name:

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

Gene

GNB3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiF5H0S8.

Names & Taxonomyi

Protein namesi
Submitted name:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3Imported
Gene namesi
Name:GNB3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:4400. GNB3.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000111664.

PTM / Processingi

Proteomic databases

PeptideAtlasiF5H0S8.
PRIDEiF5H0S8.

Expressioni

Gene expression databases

BgeeiENSG00000111664.
ExpressionAtlasiF5H0S8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF5H0S8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 264WD_REPEATS_REGIONInterPro annotationAdd BLAST214
Repeati51 – 92WDPROSITE-ProRule annotationAdd BLAST42
Repeati139 – 180WDPROSITE-ProRule annotationAdd BLAST42
Repeati181 – 222WDPROSITE-ProRule annotationAdd BLAST42
Repeati232 – 264WDPROSITE-ProRule annotationAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 31Sequence analysisAdd BLAST31

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, WD repeatPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119239.

Family and domain databases

InterProiView protein in InterPro
IPR001632. Gprotein_B.
IPR016346. Guanine_nucleotide-bd_bsu.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
PANTHERiPTHR19850. PTHR19850. 1 hit.
PfamiView protein in Pfam
PF00400. WD40. 5 hits.
PRINTSiPR00319. GPROTEINB.
SMARTiView protein in SMART
SM00320. WD40. 5 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Fragment.

F5H0S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEMEQLRQE AEQLKKQIAD ARKACADVTL AELVSGLEVV GRVQMRTRRT
60 70 80 90 100
LRGHLAKIYA MHWATDSKLL VSASQDGKLI VWDSYTTNKV HAIPLRSSWV
110 120 130 140 150
MTCAYAPSGN FVACGGLDNM CSIYNLKSRE GNVKVSRELS AHTGYLSCCR
160 170 180 190 200
FLDDNNIVTS SGDTTCAKLW DVREGTCRQT FTGHESDINA ICFFPNGEAI
210 220 230 240 250
CTGSDDASCR LFDLRADQEL ICFSHESIIC GITSVAFSLS GRLLFAGYDD
260
FNCNVWDSMK SERV
Length:264
Mass (Da):29,245
Last modified:October 5, 2016 - v8
Checksum:i0F2CAD91614E478A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei264Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47924 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000537035; ENSP00000445967; ENSG00000111664.
UCSCiuc058klw.1. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiF5H0S8_HUMAN
AccessioniPrimary (citable) accession number: F5H0S8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: October 5, 2016
Last modified: June 7, 2017
This is version 49 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported