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F5H0N8

- F5H0N8_HUMAN

UniProt

F5H0N8 - F5H0N8_HUMAN

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Protein
Submitted name:

Tyrosine-protein phosphatase non-receptor type 6

Gene

PTPN6

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: Ensembl

GO - Biological processi

  1. abortive mitotic cell cycle Source: Ensembl
  2. B cell receptor signaling pathway Source: Ensembl
  3. intracellular signal transduction Source: Ensembl
  4. megakaryocyte development Source: Ensembl
  5. natural killer cell mediated cytotoxicity Source: Ensembl
  6. negative regulation of B cell receptor signaling pathway Source: Ensembl
  7. negative regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
  8. negative regulation of MAP kinase activity Source: Ensembl
  9. negative regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  10. negative regulation of T cell proliferation Source: Ensembl
  11. negative regulation of T cell receptor signaling pathway Source: Ensembl
  12. platelet aggregation Source: Ensembl
  13. platelet formation Source: Ensembl
  14. positive regulation of cell adhesion mediated by integrin Source: Ensembl
  15. regulation of B cell differentiation Source: Ensembl
  16. regulation of release of sequestered calcium ion into cytosol Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiF5H0N8.

Names & Taxonomyi

Protein namesi
Submitted name:
Tyrosine-protein phosphatase non-receptor type 6Imported
Gene namesi
Name:PTPN6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:9658. PTPN6.

Subcellular locationi

GO - Cellular componenti

  1. alpha-beta T cell receptor complex Source: Ensembl
  2. cell-cell junction Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiF5H0N8.
ExpressionAtlasiF5H0N8. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliF5H0N8.
SMRiF5H0N8. Positions 1-165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00770000120452.

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
InterProiIPR000980. SH2.
[Graphical view]
PfamiPF00017. SH2. 2 hits.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 2 hits.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

F5H0N8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRWFHRDLS GLDAETLLKG RGVHGSFLAR PSRKNQGDFS LSVRVGDQVT
60 70 80 90 100
HIRIQNSGDF YDLYGGEKFA TLTELVEYYT QQQGVLQDRD GTIIHLKYPL
110 120 130 140 150
NCSDPTSERW YHGHMSGGQA ETLLQAKGEP WTFLVRESLS QPGDFVLSVL
160
SDQPKAGPGS PLRVT
Length:165
Mass (Da):18,466
Last modified:June 28, 2011 - v1
Checksum:iF397202648A73E90
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei165 – 1651Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47924 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000538715; ENSP00000438740; ENSG00000111679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47924 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali F5H0N8.
SMRi F5H0N8. Positions 1-165.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi F5H0N8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000538715 ; ENSP00000438740 ; ENSG00000111679 .

Organism-specific databases

HGNCi HGNC:9658. PTPN6.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00770000120452.

Enzyme and pathway databases

SignaLinki F5H0N8.

Miscellaneous databases

ChiTaRSi PTPN6. human.
NextBioi 35508058.

Gene expression databases

Bgeei F5H0N8.
ExpressionAtlasi F5H0N8. baseline and differential.

Family and domain databases

Gene3Di 3.30.505.10. 2 hits.
InterProi IPR000980. SH2.
[Graphical view ]
Pfami PF00017. SH2. 2 hits.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
SMARTi SM00252. SH2. 2 hits.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 2 hits.
PROSITEi PS50001. SH2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A., null.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiF5H0N8_HUMAN
AccessioniPrimary (citable) accession number: F5H0N8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 26, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3