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F5H049

- F5H049_HUMAN

UniProt

F5H049 - F5H049_HUMAN

Protein
Submitted name:

Nik-related protein kinase

Gene

NRK

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: InterPro
    3. small GTPase regulator activity Source: InterPro

    GO - Biological processi

    1. activation of JNKK activity Source: Ensembl
    2. negative regulation of cell proliferation Source: Ensembl
    3. parturition Source: Ensembl
    4. regulation of spongiotrophoblast cell proliferation Source: Ensembl

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiF5H049.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Nik-related protein kinaseImported
    Gene namesi
    Name:NRKImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:25391. NRK.

    PTM / Processingi

    Proteomic databases

    PRIDEiF5H049.

    Expressioni

    Gene expression databases

    ArrayExpressiF5H049.
    BgeeiF5H049.

    Structurei

    3D structure databases

    ProteinModelPortaliF5H049.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    OMAiEDIFNQH.
    PhylomeDBiF5H049.
    TreeFamiTF105138.

    Family and domain databases

    InterProiIPR001180. Citron.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00780. CNH. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50219. CNH. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F5H049-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGPGGWRDR EVTDLGHLPD PTGIFSLDKT IGLGTYGRIY LGLHEKTGAF     50
    TAVKVMNARK TPLPEIGRRV RVNKYQKSVG WRYSDEEEDL RTELNLLRKY 100
    SFHKNIVSFY GAFFKLSPPG QRHQLWMVME LCAAGSVTDV VRMTSNQSLK 150
    EDWIAYICRE ILQGLAHLHA HRVIHRDIKG QNVLLTHNAE VKLVDFGVSA 200
    QVSRTNGRRN SFIGTPYWMA PEVIDCDEDP RRSYDYRSDV WSVGITAIEM 250
    AEGAPPLCNL QPLEALFVIL RESAPTVKSS GWSRKFHNFM EKCTIKNFLF 300
    RPTSANMLQH PFVRDIKNER HVVESLTRHL TGIIKKRQKK KGIPLIFERE 350
    EAIKEQYTVR RFRGPSCTHE LLRLPTSSRC RPLRVLHGEP SQPRWLPDRE 400
    EPQVQALQQL QGAARVFMPL QALDSAPKPL KGQAQAPQRL QGAARVFMPL 450
    QAQVKAKASK PLQMQIKAPP RLRRAARVLM PLQAQVRAPR LLQVQSQVSK 500
    KQQAQTQTSE PQDLDQVPEE FQGQDQVPEQ QRQGQAPEQQ QRHNQVPEQE 550
    LEQNQAPEQP EVQEQAAEPA QAETEAEEPE SLRVNAQVFL PLLSQDHHVL 600
    LPLHLDTQVL IPVEGQTEGS PQAQAWTLEP PQAIGSVQAL IEGLSRDLLR 650
    APNSNNSKPL GPLQTLMENL SSNRFYSQPE QAREKKSKVS TLRQALAKRL 700
    SPKRFRAKSS WRPEKLELSD LEARRQRRQR RWEDIFNQHE EELRQVDKDK 750
    EDESSDNDEV FHSIQAEVQI EPLKPYISNP KKIEVQERSP SVPNNQDHAH 800
    HVKFSSSVPQ RSLLEQAQKP IDIRQRSSQN RQNWLAASES SSEEESPVTG 850
    RRSQSSPPYS TIDQKLLVDI HVPDGFKVGK ISPPVYLTNE WVGYNALSEI 900
    FRNDWLTPAP VIQPPEEDGD YVELYDASAD TDGDDDDESN DTFEDTYDHA 950
    NGNDDLDNQV DQANDVCKDH DDDNNKFVDD VNNNYYEAPS CPRASYGRDG 1000
    SCKQDGYDGS RGKEEAYRGY GSHTANRSHG GSAASEDNAA IGDQEEHAAN 1050
    IGSERRGSEG DGGKGVVRTS EESGALGLNG EENCSETDGP GLKRPASQDF 1100
    EYLQEEPGGG NEASNAIDSG AAPSAPDHES DNKDISESST QSDFSANHSS 1150
    PSKGSGMSAD ANFASAILYA GFVEVPEESP KQPSEVNVNP LYVSPACKKP 1200
    LIHMYEKEFT SEICCGSLWG VNLLLGTRSN LYLMDRSGKA DITKLIRRRP 1250
    FRQIQVLEPL NLLITISGHK NRLRVYHLTW LRNKILNNDP ESKRRQEEML 1300
    KTEEACKAID KLTGCEHFSV LQHEETTYIA IALKSSIHLY AWAPKSFDES 1350
    TAIKVCIDQS ADSEGDYMSY QAYIRILAKI QAADPVNRFK RPDELLHLLK 1400
    LKVFPTLDHK PVTVDLAIGS EKRLKIFFSS ADGYHLIDAE SEVMSDVTLP 1450
    KNPLEIIIPQ NIIILPDCLG IGMMLTFNAE ALSVEANEQL FKKILEMWKD 1500
    IPSSIAFECT QRTTGWGQKA IEVRSLQSRV LESELKRRSI KKLRFLCTRG 1550
    DKLFFTSTLR NHHSRVYFMT LGKLEELQSN YDV 1583
    Length:1,583
    Mass (Da):178,608
    Last modified:June 28, 2011 - v1
    Checksum:i04CAAAA4651B7ECE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    KF459286 Genomic DNA. No translation available.
    KF459287 Genomic DNA. No translation available.
    KF510615 Genomic DNA. No translation available.
    Z68339 Genomic DNA. No translation available.
    Z69734 Genomic DNA. No translation available.
    Z70274 Genomic DNA. No translation available.
    Z83850 Genomic DNA. No translation available.
    Z97356 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000428173; ENSP00000438378; ENSG00000123572.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    KF459286 Genomic DNA. No translation available.
    KF459287 Genomic DNA. No translation available.
    KF510615 Genomic DNA. No translation available.
    Z68339 Genomic DNA. No translation available.
    Z69734 Genomic DNA. No translation available.
    Z70274 Genomic DNA. No translation available.
    Z83850 Genomic DNA. No translation available.
    Z97356 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali F5H049.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi F5H049.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000428173 ; ENSP00000438378 ; ENSG00000123572 .

    Organism-specific databases

    HGNCi HGNC:25391. NRK.
    GenAtlasi Search...

    Phylogenomic databases

    OMAi EDIFNQH.
    PhylomeDBi F5H049.
    TreeFami TF105138.

    Enzyme and pathway databases

    SignaLinki F5H049.

    Miscellaneous databases

    NextBioi 35507954.

    Gene expression databases

    ArrayExpressi F5H049.
    Bgeei F5H049.

    Family and domain databases

    InterProi IPR001180. Citron.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00780. CNH. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50219. CNH. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiF5H049_HUMAN
    AccessioniPrimary (citable) accession number: F5H049
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3