F5H049 (F5H049_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Nik-related protein kinase Ensembl ENSP00000438378

Gene names

Name:

NRK Ensembl ENSP00000438378

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000438378

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1583 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000438378

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304 Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of JNKK activity Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara parturition Inferred from electronic annotation. Source: Compara regulation of spongiotrophoblast cell proliferation Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro small GTPase regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F5H049 [UniParc]. Last modified June 28, 2011. Version 1. Checksum: 04CAAAA4651B7ECE	FASTA	1,583	178,608
	10 20 30 40 50 60 MAGPGGWRDR EVTDLGHLPD PTGIFSLDKT IGLGTYGRIY LGLHEKTGAF TAVKVMNARK 70 80 90 100 110 120 TPLPEIGRRV RVNKYQKSVG WRYSDEEEDL RTELNLLRKY SFHKNIVSFY GAFFKLSPPG 130 140 150 160 170 180 QRHQLWMVME LCAAGSVTDV VRMTSNQSLK EDWIAYICRE ILQGLAHLHA HRVIHRDIKG 190 200 210 220 230 240 QNVLLTHNAE VKLVDFGVSA QVSRTNGRRN SFIGTPYWMA PEVIDCDEDP RRSYDYRSDV 250 260 270 280 290 300 WSVGITAIEM AEGAPPLCNL QPLEALFVIL RESAPTVKSS GWSRKFHNFM EKCTIKNFLF 310 320 330 340 350 360 RPTSANMLQH PFVRDIKNER HVVESLTRHL TGIIKKRQKK KGIPLIFERE EAIKEQYTVR 370 380 390 400 410 420 RFRGPSCTHE LLRLPTSSRC RPLRVLHGEP SQPRWLPDRE EPQVQALQQL QGAARVFMPL 430 440 450 460 470 480 QALDSAPKPL KGQAQAPQRL QGAARVFMPL QAQVKAKASK PLQMQIKAPP RLRRAARVLM 490 500 510 520 530 540 PLQAQVRAPR LLQVQSQVSK KQQAQTQTSE PQDLDQVPEE FQGQDQVPEQ QRQGQAPEQQ 550 560 570 580 590 600 QRHNQVPEQE LEQNQAPEQP EVQEQAAEPA QAETEAEEPE SLRVNAQVFL PLLSQDHHVL 610 620 630 640 650 660 LPLHLDTQVL IPVEGQTEGS PQAQAWTLEP PQAIGSVQAL IEGLSRDLLR APNSNNSKPL 670 680 690 700 710 720 GPLQTLMENL SSNRFYSQPE QAREKKSKVS TLRQALAKRL SPKRFRAKSS WRPEKLELSD 730 740 750 760 770 780 LEARRQRRQR RWEDIFNQHE EELRQVDKDK EDESSDNDEV FHSIQAEVQI EPLKPYISNP 790 800 810 820 830 840 KKIEVQERSP SVPNNQDHAH HVKFSSSVPQ RSLLEQAQKP IDIRQRSSQN RQNWLAASES 850 860 870 880 890 900 SSEEESPVTG RRSQSSPPYS TIDQKLLVDI HVPDGFKVGK ISPPVYLTNE WVGYNALSEI 910 920 930 940 950 960 FRNDWLTPAP VIQPPEEDGD YVELYDASAD TDGDDDDESN DTFEDTYDHA NGNDDLDNQV 970 980 990 1000 1010 1020 DQANDVCKDH DDDNNKFVDD VNNNYYEAPS CPRASYGRDG SCKQDGYDGS RGKEEAYRGY 1030 1040 1050 1060 1070 1080 GSHTANRSHG GSAASEDNAA IGDQEEHAAN IGSERRGSEG DGGKGVVRTS EESGALGLNG 1090 1100 1110 1120 1130 1140 EENCSETDGP GLKRPASQDF EYLQEEPGGG NEASNAIDSG AAPSAPDHES DNKDISESST 1150 1160 1170 1180 1190 1200 QSDFSANHSS PSKGSGMSAD ANFASAILYA GFVEVPEESP KQPSEVNVNP LYVSPACKKP 1210 1220 1230 1240 1250 1260 LIHMYEKEFT SEICCGSLWG VNLLLGTRSN LYLMDRSGKA DITKLIRRRP FRQIQVLEPL 1270 1280 1290 1300 1310 1320 NLLITISGHK NRLRVYHLTW LRNKILNNDP ESKRRQEEML KTEEACKAID KLTGCEHFSV 1330 1340 1350 1360 1370 1380 LQHEETTYIA IALKSSIHLY AWAPKSFDES TAIKVCIDQS ADSEGDYMSY QAYIRILAKI 1390 1400 1410 1420 1430 1440 QAADPVNRFK RPDELLHLLK LKVFPTLDHK PVTVDLAIGS EKRLKIFFSS ADGYHLIDAE 1450 1460 1470 1480 1490 1500 SEVMSDVTLP KNPLEIIIPQ NIIILPDCLG IGMMLTFNAE ALSVEANEQL FKKILEMWKD 1510 1520 1530 1540 1550 1560 IPSSIAFECT QRTTGWGQKA IEVRSLQSRV LESELKRRSI KKLRFLCTRG DKLFFTSTLR 1570 1580 NHHSRVYFMT LGKLEELQSN YDV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z68339 Genomic DNA. No translation available. Z69734 Genomic DNA. No translation available. Z70274 Genomic DNA. No translation available. Z83850 Genomic DNA. No translation available. Z97356 Genomic DNA. No translation available.
IPI	IPI00871409.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	F5H049.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000428173; ENSP00000438378; ENSG00000123572.
Organism-specific databases
HGNC	HGNC:25391. NRK.
GenAtlas	Search...
Phylogenomic databases
OMA	PPLCNLQ.
Enzyme and pathway databases
SignaLink	F5H049.
Gene expression databases
ArrayExpress	F5H049.
Bgee	F5H049.
Family and domain databases
InterPro	IPR001180. Citron. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00780. CNH. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50219. CNH. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35507954.

Entry information

Entry name

F5H049_HUMAN

Accession

Primary (citable) accession number: F5H049

Entry history

Integrated into UniProtKB/TrEMBL:	June 28, 2011
Last sequence update:	June 28, 2011
Last modified:	May 29, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.