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Protein
Submitted name:

Scavenger receptor cysteine-rich type 1 protein M130

Gene

CD163

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Scavenger receptor cysteine-rich type 1 protein M130Imported
Gene namesi
Name:CD163Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:1631. CD163.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1039 – 1059HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177575.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_500332300034 – 1109Sequence analysisAdd BLAST1076

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi108 ↔ 118PROSITE-ProRule annotation
Disulfide bondi172 ↔ 236PROSITE-ProRule annotation
Disulfide bondi185 ↔ 246PROSITE-ProRule annotation
Disulfide bondi216 ↔ 226PROSITE-ProRule annotation
Disulfide bondi279 ↔ 343PROSITE-ProRule annotation
Disulfide bondi292 ↔ 353PROSITE-ProRule annotation
Disulfide bondi323 ↔ 333PROSITE-ProRule annotation
Disulfide bondi386 ↔ 450PROSITE-ProRule annotation
Disulfide bondi399 ↔ 460PROSITE-ProRule annotation
Disulfide bondi430 ↔ 440PROSITE-ProRule annotation
Disulfide bondi491 ↔ 555PROSITE-ProRule annotation
Disulfide bondi504 ↔ 565PROSITE-ProRule annotation
Disulfide bondi535 ↔ 545PROSITE-ProRule annotation
Disulfide bondi596 ↔ 660PROSITE-ProRule annotation
Disulfide bondi609 ↔ 670PROSITE-ProRule annotation
Disulfide bondi640 ↔ 650PROSITE-ProRule annotation
Disulfide bondi732 ↔ 796PROSITE-ProRule annotation
Disulfide bondi745 ↔ 806PROSITE-ProRule annotation
Disulfide bondi776 ↔ 786PROSITE-ProRule annotation
Disulfide bondi839 ↔ 903PROSITE-ProRule annotation
Disulfide bondi852 ↔ 913PROSITE-ProRule annotation
Disulfide bondi883 ↔ 893PROSITE-ProRule annotation
Disulfide bondi942 ↔ 1006PROSITE-ProRule annotation
Disulfide bondi955 ↔ 1016PROSITE-ProRule annotation
Disulfide bondi986 ↔ 996PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiF5GZZ9.
PRIDEiF5GZZ9.

Expressioni

Gene expression databases

BgeeiENSG00000177575.
ExpressionAtlasiF5GZZ9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000352071.

Structurei

3D structure databases

ProteinModelPortaliF5GZZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 140SRCRInterPro annotationAdd BLAST102
Domaini147 – 247SRCRInterPro annotationAdd BLAST101
Domaini254 – 354SRCRInterPro annotationAdd BLAST101
Domaini361 – 461SRCRInterPro annotationAdd BLAST101
Domaini466 – 566SRCRInterPro annotationAdd BLAST101
Domaini571 – 671SRCRInterPro annotationAdd BLAST101
Domaini707 – 807SRCRInterPro annotationAdd BLAST101
Domaini812 – 914SRCRInterPro annotationAdd BLAST103
Domaini917 – 1017SRCRInterPro annotationAdd BLAST101

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IHBC. Eukaryota.
ENOG410XQVR. LUCA.
GeneTreeiENSGT00870000136382.

Family and domain databases

InterProiView protein in InterPro
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
PfamiView protein in Pfam
PF00530. SRCR. 9 hits.
PRINTSiPR00258. SPERACTRCPTR.
SMARTiView protein in SMART
SM00202. SR. 9 hits.
SUPFAMiSSF56487. SSF56487. 9 hits.
PROSITEiView protein in PROSITE
PS00420. SRCR_1. 4 hits.
PS50287. SRCR_2. 9 hits.

Sequencei

Sequence statusi: Complete.

F5GZZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLDFRRHFV NLSPFTITVV LLLSACFVTS SLGGTDKELR LVDGENKCSG
60 70 80 90 100
RVEVKVQEEW GTVCNNGWSM EAVSVICNQL GCPTAIKAPG WANSSAGSGR
110 120 130 140 150
IWMDHVSCRG NESALWDCKH DGWGKHSNCT HQQDAGVTCS DGSNLEMRLT
160 170 180 190 200
RGGNMCSGRI EIKFQGRWGT VCDDNFNIDH ASVICRQLEC GSAVSFSGSS
210 220 230 240 250
NFGEGSGPIW FDDLICNGNE SALWNCKHQG WGKHNCDHAE DAGVICSKGA
260 270 280 290 300
DLSLRLVDGV TECSGRLEVR FQGEWGTICD DGWDSYDAAV ACKQLGCPTA
310 320 330 340 350
VTAIGRVNAS KGFGHIWLDS VSCQGHEPAI WQCKHHEWGK HYCNHNEDAG
360 370 380 390 400
VTCSDGSDLE LRLRGGGSRC AGTVEVEIQR LLGKVCDRGW GLKEADVVCR
410 420 430 440 450
QLGCGSALKT SYQVYSKIQA TNTWLFLSSC NGNETSLWDC KNWQWGGLTC
460 470 480 490 500
DHYEEAKITC SAHREPRLVG GDIPCSGRVE VKHGDTWGSI CDSDFSLEAA
510 520 530 540 550
SVLCRELQCG TVVSILGGAH FGEGNGQIWA EEFQCEGHES HLSLCPVAPR
560 570 580 590 600
PEGTCSHSRD VGVVCSRYTE IRLVNGKTPC EGRVELKTLG AWGSLCNSHW
610 620 630 640 650
DIEDAHVLCQ QLKCGVALST PGGARFGKGN GQIWRHMFHC TGTEQHMGDC
660 670 680 690 700
PVTALGASLC PSEQVASVIC SGNQSQTLSS CNSSSLGPTR PTIPEESAVA
710 720 730 740 750
CIESGQLRLV NGGGRCAGRV EIYHEGSWGT ICDDSWDLSD AHVVCRQLGC
760 770 780 790 800
GEAINATGSA HFGEGTGPIW LDEMKCNGKE SRIWQCHSHG WGQQNCRHKE
810 820 830 840 850
DAGVICSEFM SLRLTSEASR EACAGRLEVF YNGAWGTVGK SSMSETTVGV
860 870 880 890 900
VCRQLGCADK GKINPASLDK AMSIPMWVDN VQCPKGPDTL WQCPSSPWEK
910 920 930 940 950
RLASPSEETW ITCDNKIRLQ EGPTSCSGRV EIWHGGSWGT VCDDSWDLDD
960 970 980 990 1000
AQVVCQQLGC GPALKAFKEA EFGQGTGPIW LNEVKCKGNE SSLWDCPARR
1010 1020 1030 1040 1050
WGHSECGHKE DAAVNCTDIS VQKTPQKATT GRSSRQSSFI AVGILGVVLL
1060 1070 1080 1090 1100
AIFVALFFLT KKRRQRQRLA VSSRGENLVH QIQYREMNSC LNADDLDLMN

SSGGHSEPH
Length:1,109
Mass (Da):120,322
Last modified:June 28, 2011 - v1
Checksum:i50B73BFE15FD32EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131206 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000541972; ENSP00000444071; ENSG00000177575.
UCSCiuc058kto.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131206 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliF5GZZ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000352071.

Proteomic databases

PaxDbiF5GZZ9.
PRIDEiF5GZZ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000541972; ENSP00000444071; ENSG00000177575.
UCSCiuc058kto.1. human.

Organism-specific databases

HGNCiHGNC:1631. CD163.
OpenTargetsiENSG00000177575.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHBC. Eukaryota.
ENOG410XQVR. LUCA.
GeneTreeiENSGT00870000136382.

Miscellaneous databases

ChiTaRSiCD163. human.

Gene expression databases

BgeeiENSG00000177575.
ExpressionAtlasiF5GZZ9. baseline and differential.

Family and domain databases

InterProiView protein in InterPro
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
PfamiView protein in Pfam
PF00530. SRCR. 9 hits.
PRINTSiPR00258. SPERACTRCPTR.
SMARTiView protein in SMART
SM00202. SR. 9 hits.
SUPFAMiSSF56487. SSF56487. 9 hits.
PROSITEiView protein in PROSITE
PS00420. SRCR_1. 4 hits.
PS50287. SRCR_2. 9 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiF5GZZ9_HUMAN
AccessioniPrimary (citable) accession number: F5GZZ9
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: April 12, 2017
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.