F5GZQ3 (F5GZQ3_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
3-ketoacyl-CoA thiolase Ensembl ENSP00000444295

Gene names

Name:

HADHB Ensembl ENSP00000444295

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000444295

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	459 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the thiolase family. RuleBase RU003557
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000444295

Ontologies

Keywords
Molecular function	Acyltransferase RuleBase RU003558 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	transferase activity, transferring acyl groups other than amino-acyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F5GZQ3 [UniParc]. Last modified June 28, 2011. Version 1. Checksum: CED0D1A038DD1512	FASTA	459	49,597
	10 20 30 40 50 60 MTILTYPFKN LPTASKWALR FSIRPLSCSS QLRAAPAVQT KTKKTLAKPN IRNVVVVDGV 70 80 90 100 110 120 RTPFLLSGTS GLLHRTSVPK EVVDYIIFGT VIQEVKTSNV AREAALGAGF SDKTPAHTVT 130 140 150 160 170 180 MACISANQAM TTGVGLIASG QCDVIVAGGV ELMSDVPIRH SRKMRKLMLD LNKAKSMGQR 190 200 210 220 230 240 LSLISKFRFN FLAPELPAVS EFSTSETMGH SADRLAAAFA VSRLEQDEYA LRSHSLAKKA 250 260 270 280 290 300 QDEGLLSDVV PFKVPGKDTV TKDNGIRPSS LEQMAKLKPA FIKPYGTVTA ANSSFLTDGA 310 320 330 340 350 360 SAMLIMAEEK ALAMGYKPKA YLRDFMYVSQ DPKDQLLLGP TYATPKVLEK AGLTMNDIDA 370 380 390 400 410 420 FEFHEAFSGQ ILANFKAMDS DWFAENYMGR KTKVGLPPLE KFNNWGGSLS LGHPFGATGC 430 440 450 RLVMAAANRL RKEGGQYGLV AACAAGGQGH AMIVEAYPK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC010896 Genomic DNA. No translation available.
IPI	IPI01015627.
3D structure databases
ProteinModelPortal	F5GZQ3.
SMR	F5GZQ3. Positions 50-455.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000537713; ENSP00000444295; ENSG00000138029.
UCSC	uc010ykw.2. human.
Organism-specific databases
HGNC	HGNC:4803. HADHB.
GenAtlas	Search...
Gene expression databases
ArrayExpress	F5GZQ3.
Bgee	F5GZQ3.
Family and domain databases
Gene3D	3.40.47.10. 4 hits.
InterPro	IPR002155. Thiolase. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. IPR020615. Thiolase_acyl_enz_int_AS. IPR020610. Thiolase_AS. IPR020617. Thiolase_C. IPR020613. Thiolase_CS. IPR020616. Thiolase_N. [Graphical view]
PANTHER	PTHR18919. PTHR18919. 1 hit.
Pfam	PF02803. Thiolase_C. 1 hit. PF00108. Thiolase_N. 1 hit. [Graphical view]
SUPFAM	SSF53901. Thiolase-like. 2 hits.
TIGRFAMs	TIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITE	PS00098. THIOLASE_1. 1 hit. PS00737. THIOLASE_2. 1 hit. PS00099. THIOLASE_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HADHB. human.
NextBio	35507864.

Entry information

Entry name

F5GZQ3_HUMAN

Accession

Primary (citable) accession number: F5GZQ3

Entry history

Integrated into UniProtKB/TrEMBL:	June 28, 2011
Last sequence update:	June 28, 2011
Last modified:	May 1, 2013
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.