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F5GZQ3

- F5GZQ3_HUMAN

UniProt

F5GZQ3 - F5GZQ3_HUMAN

Protein
Submitted name:

3-ketoacyl-CoA thiolase

Gene

HADHB

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. transferase activity, transferring acyl groups other than amino-acyl groups Source: InterPro

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotation, Transferase

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    3-ketoacyl-CoA thiolaseImported
    Gene namesi
    Name:HADHBImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:4803. HADHB.

    Expressioni

    Gene expression databases

    ArrayExpressiF5GZQ3.
    BgeeiF5GZQ3.

    Structurei

    3D structure databases

    ProteinModelPortaliF5GZQ3.
    SMRiF5GZQ3. Positions 50-455.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thiolase family.UniRule annotation

    Phylogenomic databases

    KOiK07509.

    Family and domain databases

    Gene3Di3.40.47.10. 4 hits.
    InterProiIPR002155. Thiolase.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    IPR020615. Thiolase_acyl_enz_int_AS.
    IPR020610. Thiolase_AS.
    IPR020617. Thiolase_C.
    IPR020613. Thiolase_CS.
    IPR020616. Thiolase_N.
    [Graphical view]
    PfamiPF02803. Thiolase_C. 1 hit.
    PF00108. Thiolase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF53901. SSF53901. 2 hits.
    TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
    PROSITEiPS00098. THIOLASE_1. 1 hit.
    PS00737. THIOLASE_2. 1 hit.
    PS00099. THIOLASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F5GZQ3-1 [UniParc]FASTAAdd to Basket

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    MTILTYPFKN LPTASKWALR FSIRPLSCSS QLRAAPAVQT KTKKTLAKPN    50
    IRNVVVVDGV RTPFLLSGTS GLLHRTSVPK EVVDYIIFGT VIQEVKTSNV 100
    AREAALGAGF SDKTPAHTVT MACISANQAM TTGVGLIASG QCDVIVAGGV 150
    ELMSDVPIRH SRKMRKLMLD LNKAKSMGQR LSLISKFRFN FLAPELPAVS 200
    EFSTSETMGH SADRLAAAFA VSRLEQDEYA LRSHSLAKKA QDEGLLSDVV 250
    PFKVPGKDTV TKDNGIRPSS LEQMAKLKPA FIKPYGTVTA ANSSFLTDGA 300
    SAMLIMAEEK ALAMGYKPKA YLRDFMYVSQ DPKDQLLLGP TYATPKVLEK 350
    AGLTMNDIDA FEFHEAFSGQ ILANFKAMDS DWFAENYMGR KTKVGLPPLE 400
    KFNNWGGSLS LGHPFGATGC RLVMAAANRL RKEGGQYGLV AACAAGGQGH 450
    AMIVEAYPK 459
    Length:459
    Mass (Da):49,597
    Last modified:June 28, 2011 - v1
    Checksum:iCED0D1A038DD1512
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC010896 Genomic DNA. No translation available.
    RefSeqiNP_001268441.1. NM_001281512.1.
    UniGeneiHs.515848.

    Genome annotation databases

    EnsembliENST00000537713; ENSP00000444295; ENSG00000138029.
    GeneIDi3032.
    KEGGihsa:3032.
    UCSCiuc010ykw.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC010896 Genomic DNA. No translation available.
    RefSeqi NP_001268441.1. NM_001281512.1.
    UniGenei Hs.515848.

    3D structure databases

    ProteinModelPortali F5GZQ3.
    SMRi F5GZQ3. Positions 50-455.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000537713 ; ENSP00000444295 ; ENSG00000138029 .
    GeneIDi 3032.
    KEGGi hsa:3032.
    UCSCi uc010ykw.2. human.

    Organism-specific databases

    CTDi 3032.
    HGNCi HGNC:4803. HADHB.
    GenAtlasi Search...

    Phylogenomic databases

    KOi K07509.

    Miscellaneous databases

    ChiTaRSi HADHB. human.
    GenomeRNAii 3032.
    NextBioi 35507864.

    Gene expression databases

    ArrayExpressi F5GZQ3.
    Bgeei F5GZQ3.

    Family and domain databases

    Gene3Di 3.40.47.10. 4 hits.
    InterProi IPR002155. Thiolase.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    IPR020615. Thiolase_acyl_enz_int_AS.
    IPR020610. Thiolase_AS.
    IPR020617. Thiolase_C.
    IPR020613. Thiolase_CS.
    IPR020616. Thiolase_N.
    [Graphical view ]
    Pfami PF02803. Thiolase_C. 1 hit.
    PF00108. Thiolase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53901. SSF53901. 2 hits.
    TIGRFAMsi TIGR01930. AcCoA-C-Actrans. 1 hit.
    PROSITEi PS00098. THIOLASE_1. 1 hit.
    PS00737. THIOLASE_2. 1 hit.
    PS00099. THIOLASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiF5GZQ3_HUMAN
    AccessioniPrimary (citable) accession number: F5GZQ3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3