F5GZG6 (F5GZG6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Thiamin pyrophosphokinase 1 Ensembl ENSP00000367339

Gene names

Name:

TPK1 Ensembl ENSP00000367339

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000367339

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000367339

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	thiamine diphosphate biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro thiamine diphosphokinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F5GZG6 [UniParc]. Last modified June 28, 2011. Version 1. Checksum: C673F868C40E8948	FASTA	194	21,886
	10 20 30 40 50 60 MEHAFTPLEP LLSTGNLKYC LVILNQPLDN YFRHLWNKAL LRACADGGAN RLYDITEGER 70 80 90 100 110 120 ESFLPEFING DFDSIRPEVR EYYATKGCEL ISTPDQDHTD FTKCLKMLQK KIEEKDLKGK 130 140 150 160 170 180 HRLHVDTGME GDWCGLIPVG QPCMQVTTTG LKWNLTNDVL AFGTLVSTSN TYDGSGVVTV 190 ETDHPLLWTM AIKS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC004534 Genomic DNA. No translation available. AC004743 Genomic DNA. No translation available. AC004833 Genomic DNA. No translation available. AC004864 Genomic DNA. No translation available. AC005677 Genomic DNA. No translation available. AC074384 Genomic DNA. No translation available.
IPI	IPI00418733.
RefSeq	NP_001035947.1. NM_001042482.1.
UniGene	Hs.660232.
3D structure databases
ProteinModelPortal	F5GZG6.
SMR	F5GZG6. Positions 16-193.
ModBase	Search...
Proteomic databases
PRIDE	F5GZG6.
Protocols and materials databases
DNASU	27010.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000378099; ENSP00000367339; ENSG00000196511.
GeneID	27010.
KEGG	hsa:27010.
UCSC	uc003wer.3. human.
Organism-specific databases
CTD	27010.
HGNC	HGNC:17358. TPK1.
GenAtlas	Search...
Phylogenomic databases
KO	K00949.
Gene expression databases
ArrayExpress	F5GZG6.
Bgee	F5GZG6.
Family and domain databases
Gene3D	2.60.120.320. 1 hit. 3.40.50.10240. 1 hit.
InterPro	IPR016966. Thiamin_pyrophosphokinase_euk. IPR007373. Thiamin_PyroPKinase_B1-bd. IPR007371. TPK_catalytic. [Graphical view]
Pfam	PF04265. TPK_B1_binding. 1 hit. PF04263. TPK_catalytic. 1 hit. [Graphical view]
PIRSF	PIRSF031057. Thiamin_pyrophosphokinase. 1 hit.
SMART	SM00983. TPK_B1_binding. 1 hit. [Graphical view]
SUPFAM	SSF63999. TPK_catalytic. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	TPK1. human.
GenomeRNAi	27010.
NextBio	49516.

Entry information

Entry name

F5GZG6_HUMAN

Accession

Primary (citable) accession number: F5GZG6

Entry history

Integrated into UniProtKB/TrEMBL:	June 28, 2011
Last sequence update:	June 28, 2011
Last modified:	April 3, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.