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Protein

Matrix metalloproteinase

Gene

MMP17

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Ca2+UniRule annotation
  • Zn2+UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, MetalloproteaseUniRule annotation, Protease
LigandCalciumUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix metalloproteinaseUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:MMP17Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000198598.6.
HGNCiHGNC:7163. MMP17.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198598.

PTM / Processingi

Keywords - PTMi

ZymogenUniRule annotation

Proteomic databases

PaxDbiF5GZA7.
PeptideAtlasiF5GZA7.
PRIDEiF5GZA7.

Expressioni

Gene expression databases

BgeeiENSG00000198598.
ExpressionAtlasiF5GZA7. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF5GZA7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 168ZnMcInterPro annotationAdd BLAST144

Sequence similaritiesi

Belongs to the peptidase M10A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00760000118870.

Family and domain databases

CDDicd04278. ZnMc_MMP. 1 hit.
Gene3Di3.40.390.10. 1 hit.
InterProiView protein in InterPro
IPR033739. M10A_MMP.
IPR024079. MetalloPept_cat_dom_sf.
IPR028726. MMP17.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR006026. Peptidase_Metallo.
PANTHERiPTHR10201:SF21. PTHR10201:SF21. 1 hit.
PfamiView protein in Pfam
PF00413. Peptidase_M10. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiView protein in SMART
SM00235. ZnMc. 1 hit.

Sequencei

Sequence statusi: Fragment.

F5GZA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTPRCSLPD LPVLTQARRR RQAPAPTKWN KRNLSWRVRT FPRDSPLGHD
60 70 80 90 100
TVRALMYYAL KVWSDIAPLN FHEVAGSAAD IQIDFSKADH NDGYPFDGPG
110 120 130 140 150
GTVAHAFFPG HHHTAGDTHF DDDEAWTFRS SDAHGMDLFA VAVHEFGHAI
160
GLSHVAAAHS IMRPYYQGP
Length:169
Mass (Da):18,869
Last modified:June 28, 2011 - v1
Checksum:i6FAAE5CC0115BB7B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei169Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131009 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000545671; ENSP00000444603; ENSG00000198598.
UCSCiuc058vgt.1. human.

Similar proteinsi

Entry informationi

Entry nameiF5GZA7_HUMAN
AccessioniPrimary (citable) accession number: F5GZA7
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 22, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported