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Protein

Matrix metalloproteinase

Gene

MMP17

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Ca2+UniRule annotation
  • Zn2+UniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, MetalloproteaseUniRule annotation, Protease
LigandCalciumUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix metalloproteinaseUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:MMP17Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000198598.6
HGNCiHGNC:7163 MMP17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198598

PTM / Processingi

Keywords - PTMi

ZymogenUniRule annotation

Proteomic databases

PeptideAtlasiF5GZA7

Expressioni

Gene expression databases

BgeeiENSG00000198598
ExpressionAtlasiF5GZA7 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF5GZA7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 168ZnMcInterPro annotationAdd BLAST144

Sequence similaritiesi

Belongs to the peptidase M10A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00760000118870

Family and domain databases

CDDicd04278 ZnMc_MMP, 1 hit
Gene3Di3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR033739 M10A_MMP
IPR024079 MetalloPept_cat_dom_sf
IPR028726 MMP17
IPR001818 Pept_M10_metallopeptidase
IPR021190 Pept_M10A
IPR006026 Peptidase_Metallo
PANTHERiPTHR10201:SF21 PTHR10201:SF21, 1 hit
PfamiView protein in Pfam
PF00413 Peptidase_M10, 1 hit
PRINTSiPR00138 MATRIXIN
SMARTiView protein in SMART
SM00235 ZnMc, 1 hit

Sequencei

Sequence statusi: Fragment.

F5GZA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTPRCSLPD LPVLTQARRR RQAPAPTKWN KRNLSWRVRT FPRDSPLGHD
60 70 80 90 100
TVRALMYYAL KVWSDIAPLN FHEVAGSAAD IQIDFSKADH NDGYPFDGPG
110 120 130 140 150
GTVAHAFFPG HHHTAGDTHF DDDEAWTFRS SDAHGMDLFA VAVHEFGHAI
160
GLSHVAAAHS IMRPYYQGP
Length:169
Mass (Da):18,869
Last modified:June 28, 2011 - v1
Checksum:i6FAAE5CC0115BB7B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei169Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131009 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000545671; ENSP00000444603; ENSG00000198598
UCSCiuc058vgt.1 human

Similar proteinsi

Entry informationi

Entry nameiF5GZA7_HUMAN
AccessioniPrimary (citable) accession number: F5GZA7
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health