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Protein
Submitted name:

Paxillin

Gene

PXN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
PaxillinImported
Gene namesi
Name:PXNImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:9718. PXN.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiF5GZ78.
PeptideAtlasiF5GZ78.
PRIDEiF5GZ78.

Expressioni

Gene expression databases

BgeeiENSG00000089159.
ExpressionAtlasiF5GZ78. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiF5GZ78. 1 interaction.
STRINGi9606.ENSP00000228307.

Structurei

3D structure databases

ProteinModelPortaliF5GZ78.
SMRiF5GZ78. Positions 355-588.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini354 – 41360LIM zinc-bindingInterPro annotationAdd
BLAST
Domaini414 – 47158LIM zinc-bindingInterPro annotationAdd
BLAST
Domaini472 – 53160LIM zinc-bindingInterPro annotationAdd
BLAST
Domaini532 – 58958LIM zinc-bindingInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 4 LIM zinc-binding domains.UniRule annotation

Keywords - Domaini

LIM domainUniRule annotation

Phylogenomic databases

eggNOGiKOG1703. Eukaryota.
ENOG410XRD4. LUCA.
GeneTreeiENSGT00760000118910.

Family and domain databases

Gene3Di2.10.110.10. 4 hits.
InterProiIPR001904. Paxillin.
IPR001781. Znf_LIM.
[Graphical view]
PANTHERiPTHR24216:SF11. PTHR24216:SF11. 1 hit.
PfamiPF00412. LIM. 4 hits.
[Graphical view]
SMARTiSM00132. LIM. 4 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5GZ78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADALLADLE STTSHISKRP VFLSEETPYS YPTGNHTYQE IAVPPPVPPP
60 70 80 90 100
PSSEALNGTI LDPLDQWQPS SSRFIHQQPQ SSSPVYGSSA KTSSVSNPQD
110 120 130 140 150
SVGSPCSRVG EEEHVYSFPN KQKSAEPSPT VMSTSLGSNL SELDRLLLEL
160 170 180 190 200
NAVQHNPPGF PADEANSSPP LPGALSPLYG VPETNSPLGG KAGPLTKEKP
210 220 230 240 250
KRNGGRGLED VRPSVESLLD ELESSVPSPV PAITVNQGEM SSPQRVTSTQ
260 270 280 290 300
QQTRISASSA TRELDELMAS LSDFKIQGLE QRADGERCWA AGWPRDGGRS
310 320 330 340 350
SPGGQDEGGF MAQGKTGSSS PPGGPPKPGS QLDSMLGSLQ SDLNKLGVAT
360 370 380 390 400
VAKGVCGACK KPIAGQVVTA MGKTWHPEHF VCTHCQEEIG SRNFFERDGQ
410 420 430 440 450
PYCEKDYHNL FSPRCYYCNG PILDKVVTAL DRTWHPEHFF CAQCGAFFGP
460 470 480 490 500
EGFHEKDGKA YCRKDYFDMF APKCGGCARA ILENYISALN TLWHPECFVC
510 520 530 540 550
RECFTPFVNG SFFEHDGQPY CEVHYHERRG SLCSGCQKPI TGRCITAMAK
560 570 580
KFHPEHFVCA FCLKQLNKGT FKEQNDKPYC QNCFLKLFC
Length:589
Mass (Da):64,233
Last modified:June 28, 2011 - v1
Checksum:i5D0C66B428A52A24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004263 Genomic DNA. No translation available.
UniGeneiHs.446336.

Genome annotation databases

EnsembliENST00000536957; ENSP00000443887; ENSG00000089159.
UCSCiuc031qjr.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004263 Genomic DNA. No translation available.
UniGeneiHs.446336.

3D structure databases

ProteinModelPortaliF5GZ78.
SMRiF5GZ78. Positions 355-588.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiF5GZ78. 1 interaction.
STRINGi9606.ENSP00000228307.

Proteomic databases

PaxDbiF5GZ78.
PeptideAtlasiF5GZ78.
PRIDEiF5GZ78.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000536957; ENSP00000443887; ENSG00000089159.
UCSCiuc031qjr.2. human.

Organism-specific databases

CTDi5829.
HGNCiHGNC:9718. PXN.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1703. Eukaryota.
ENOG410XRD4. LUCA.
GeneTreeiENSGT00760000118910.

Miscellaneous databases

ChiTaRSiPXN. human.
GenomeRNAii5829.

Gene expression databases

BgeeiENSG00000089159.
ExpressionAtlasiF5GZ78. baseline and differential.

Family and domain databases

Gene3Di2.10.110.10. 4 hits.
InterProiIPR001904. Paxillin.
IPR001781. Znf_LIM.
[Graphical view]
PANTHERiPTHR24216:SF11. PTHR24216:SF11. 1 hit.
PfamiPF00412. LIM. 4 hits.
[Graphical view]
SMARTiSM00132. LIM. 4 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF5GZ78_HUMAN
AccessioniPrimary (citable) accession number: F5GZ78
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 7, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.