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Protein

DNA ligase

Gene

LIG1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:LIG1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105486.13
HGNCiHGNC:6598 LIG1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105486

PTM / Processingi

Proteomic databases

MaxQBiF5GZ28
PeptideAtlasiF5GZ28
PRIDEiF5GZ28

Expressioni

Gene expression databases

BgeeiENSG00000105486
ExpressionAtlasiF5GZ28 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF5GZ28
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini580 – 716DNA_LIGASE_A3InterPro annotationAdd BLAST137

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00860000133792

Family and domain databases

Gene3Di1.10.3260.101 hit
InterProiView protein in InterPro
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

F5GZ28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRSIMSFFH PKKEGKAKKP EKEASNSSRE TEPPPKAALK EWNGVVSESD
60 70 80 90 100
SPVKRPGRKA ARVLGSEGEE EDEALSPAKG QKPALDCSQV SPPRPATSPE
110 120 130 140 150
NNASLSDTSP MDSSPSGIPK RRTEAETPTE SVSEPEVATK QELQEEEEQT
160 170 180 190 200
KPPRRAPKTL SSFFTPRKPA VKKEVKEEEP GAPGKEGAAE GPLDPSGYNP
210 220 230 240 250
AKNNYHPVED ACWKPGQKVP YLAVARTFEK IEEVSARLRM VETLSNLLRS
260 270 280 290 300
VVALSPPDLL PVLYLSLNHL GPPQQGLELG VGDGVLLKAV AQATGRQLES
310 320 330 340 350
VRAEAAEKGD VGLVAENSRS TQRLMLPPPP LTASGVFSKF RDIARLTGSA
360 370 380 390 400
STAKKIDIIK GLFVACRHSE ARFIARSLSG RLRLGLAEQS VLAALSQAVS
410 420 430 440 450
LTPPGQEFPP AMVDAGKGKT AEARKTWLEE QGMILKQTFC EVPDLDRIIP
460 470 480 490 500
VLLEHGLERL PEHCKLSPGI PLKPMLAHPT RGISEVLKRF EEAAFTCEYK
510 520 530 540 550
YDGQRAQIHA LEGGEVKIFS RNQEDNTGKY PDIISRIPKI KLPSVTSFIL
560 570 580 590 600
DTEAVAWDRE KKQIQPFQVL TTRKRKEVDA SEIQVQVCLY AFDLIYLNGE
610 620 630 640 650
SLVREPLSRR RQLLRENFVE TEGEFVFATS LDTKDIEQIA EFLEQSVKDS
660 670 680 690 700
CEGLMVKTLD VDATYEIAKR SHNWLKLKKD YLDGVGDTLD LVVIGAYLGR
710 720 730 740 750
GKRAGRYGGF LLASYDEDSE ELQAICKLGT GFSDEELEEH HQSLKALVLP
760 770 780 790 800
SPRPYVRIDG AVIPDHWLDP SAVWEVKCAD LSLSPIYPAA RGLVDSDKGI
810 820 830 840 850
SLRFPRFIRV REDKQPEQAT TSAQVACLYR KQSQIQNQQG EDSGSDPEDT

Y
Length:851
Mass (Da):93,948
Last modified:June 28, 2011 - v1
Checksum:i962BAEBE37E672CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011466 Genomic DNA No translation available.
KC877741 Genomic DNA No translation available.
RefSeqiNP_001275993.1, NM_001289064.1
UniGeneiHs.1770

Genome annotation databases

EnsembliENST00000536218; ENSP00000441531; ENSG00000105486
GeneIDi3978
UCSCiuc010xzf.3 human

Similar proteinsi

Entry informationi

Entry nameiF5GZ28_HUMAN
AccessioniPrimary (citable) accession number: F5GZ28
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: April 25, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported