ID   F5GYW0_HUMAN            Unreviewed;       473 AA.
AC   F5GYW0;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   27-MAR-2024, entry version 93.
DE   SubName: Full=Centrosomal protein 57 {ECO:0000313|Ensembl:ENSP00000441392.1};
GN   Name=CEP57 {ECO:0000313|Ensembl:ENSP00000441392.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000441392.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000441392.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0007829|PubMed:21406692}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA   Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA   Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT   "System-wide temporal characterization of the proteome and phosphoproteome
RT   of human embryonic stem cell differentiation.";
RL   Sci. Signal. 4:RS3-RS3(2011).
RN   [3] {ECO:0007829|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [4] {ECO:0000313|Ensembl:ENSP00000441392.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC   -!- SIMILARITY: Belongs to the translokin family.
CC       {ECO:0000256|ARBA:ARBA00008179}.
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DR   EMBL; AP001877; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; F5GYW0; -.
DR   SMR; F5GYW0; -.
DR   IntAct; F5GYW0; 1.
DR   MassIVE; F5GYW0; -.
DR   MaxQB; F5GYW0; -.
DR   PeptideAtlas; F5GYW0; -.
DR   ProteomicsDB; 24860; -.
DR   Antibodypedia; 17918; 256 antibodies from 27 providers.
DR   Ensembl; ENST00000537677.5; ENSP00000441392.1; ENSG00000166037.11.
DR   UCSC; uc058grh.1; human.
DR   HGNC; HGNC:30794; CEP57.
DR   VEuPathDB; HostDB:ENSG00000166037; -.
DR   GeneTree; ENSGT00530000063695; -.
DR   HOGENOM; CLU_034321_2_0_1; -.
DR   OMA; DLQRSPW; -.
DR   ChiTaRS; CEP57; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000166037; Expressed in oocyte and 205 other cell types or tissues.
DR   ExpressionAtlas; F5GYW0; baseline and differential.
DR   GO; GO:0034451; C:centriolar satellite; IDA:HPA.
DR   GO; GO:0005813; C:centrosome; IDA:HPA.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR   GO; GO:0042802; F:identical protein binding; IEA:InterPro.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   Gene3D; 1.20.58.90; -; 1.
DR   InterPro; IPR025913; Cep57_CLD.
DR   InterPro; IPR024957; Cep57_MT-bd_dom.
DR   PANTHER; PTHR19336:SF11; CENTROSOMAL PROTEIN OF 57 KDA; 1.
DR   PANTHER; PTHR19336; UNCHARACTERIZED DUF1167; 1.
DR   Pfam; PF14073; Cep57_CLD; 1.
DR   Pfam; PF06657; Cep57_MT_bd; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Proteomics identification {ECO:0007829|EPD:F5GYW0,
KW   ECO:0007829|MaxQB:F5GYW0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN          41..217
FT                   /note="Cep57 centrosome localisation"
FT                   /evidence="ECO:0000259|Pfam:PF14073"
FT   DOMAIN          322..393
FT                   /note="Cep57 centrosome microtubule-binding"
FT                   /evidence="ECO:0000259|Pfam:PF06657"
FT   REGION          407..445
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          39..210
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        407..422
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   473 AA;  54526 MW;  050395F21463E850 CRC64;
     MVRHSSSPYV VYPSDKPFLN SDLRRSPSKP TLAYPESNSR AIFSALKNLQ DKIRRLELER
     IQAEESVKTL SRETIEYKKV LDEQIQEREN SKNEESKHNQ ELTSQLLAAE NKCNLLEKQL
     EYMRNMIKHA EMERTSVLEK QVSLERERQH DQTHVQSQLE KLDLLEQEYN KLTTMQALAE
     KKMQELEAKL HEEEQERKRM QAKAAELQTG LETNRLIFED KATPCVPNAR RIKKKKSKPP
     EKKSSRNYFG AQPHYRLCLG DMPFVAGKST SPSHAVVANV QLVLHLMKQH SKALCNDRVI
     NSIPLAKQVS SRGGKSKKLS VTPPSSNGIN EELSEVLQTL QDEFGQMSFD HQQLAKLIQE
     SPTVELKDKL ECELEALVGR MEAKANQITK VRKYQAQLEK QKLEKQKKEL KATKKTLDEE
     RNSSSRSGIT GTTNKKDFMK LRPGEKRRKN LQLLKDMQSI QNSLQSSSLC WDY
//