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Protein
Submitted name:

Homeobox protein Meis1

Gene

MEIS1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Homeobox protein Meis1Imported
Gene namesi
Name:MEIS1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:7000. MEIS1.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiF5GYS8.
ExpressionAtlasiF5GYS8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF5GYS8.
SMRiF5GYS8. Positions 214-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

HomeoboxUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00550000074260.
KOiK15613.
OMAiEPERPMA.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5GYS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQGLRLQGS RRKGRHPLFP LLALIFEKCE LATCTPREPG VAGGDVCSSE
60 70 80 90 100
SFNEDIAVFA KQIRAEKPLF SSNPELDNLM IQAIQVLRFH LLELEKVHEL
110 120 130 140 150
CDNFCHRYIS CLKGKMPIDL VIDDREGGSK SDSEDITRSA NLTDQPSWNR
160 170 180 190 200
DHDDTASTRS GGTPGPSSGG HTSHSGDNSS EQGDGLDNSV ASPSTGDDDD
210 220 230 240 250
PDKDKKRHKK RGIFPKVATN IMRAWLFQHL THPYPSEEQK KQLAQDTGLT
260 270 280 290 300
ILQVNNWFIN ARRRIVQPMI DQSNRAVSQG TPYNPDGQPM GGFVMDGQQH
310 320
MGIRAPGPMS GMGMNMGMEG QWHYM
Length:325
Mass (Da):36,013
Last modified:June 27, 2011 - v1
Checksum:iB56394B4E32B6D73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007392 Genomic DNA. No translation available.
AC092669 Genomic DNA. No translation available.
AC093641 Genomic DNA. No translation available.
RefSeqiXP_005264382.1. XM_005264325.2.
UniGeneiHs.526754.
Hs.603755.

Genome annotation databases

EnsembliENST00000495021; ENSP00000440571; ENSG00000143995.
GeneIDi4211.
KEGGihsa:4211.
UCSCiuc010yqi.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007392 Genomic DNA. No translation available.
AC092669 Genomic DNA. No translation available.
AC093641 Genomic DNA. No translation available.
RefSeqiXP_005264382.1. XM_005264325.2.
UniGeneiHs.526754.
Hs.603755.

3D structure databases

ProteinModelPortaliF5GYS8.
SMRiF5GYS8. Positions 214-269.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000495021; ENSP00000440571; ENSG00000143995.
GeneIDi4211.
KEGGihsa:4211.
UCSCiuc010yqi.2. human.

Organism-specific databases

CTDi4211.
HGNCiHGNC:7000. MEIS1.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00550000074260.
KOiK15613.
OMAiEPERPMA.

Miscellaneous databases

ChiTaRSiMEIS1. human.
GenomeRNAii4211.
NextBioi35507690.

Gene expression databases

BgeeiF5GYS8.
ExpressionAtlasiF5GYS8. baseline and differential.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiF5GYS8_HUMAN
AccessioniPrimary (citable) accession number: F5GYS8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 27, 2011
Last sequence update: June 27, 2011
Last modified: March 31, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationMaxQB annotation, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.