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Protein
Submitted name:

Neurexin-1-beta

Gene

NRXN1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Neurexin-1-betaImported
Gene namesi
Name:NRXN1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:8008. NRXN1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiF5GYC7.
PeptideAtlasiF5GYC7.

Expressioni

Gene expression databases

BgeeiF5GYC7.
ExpressionAtlasiF5GYC7. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000385142.

Structurei

3D structure databases

ProteinModelPortaliF5GYC7.
SMRiF5GYC7. Positions 2-836.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 188183LAM_G_DOMAINInterPro annotationAdd
BLAST
Domaini195 – 387193LAM_G_DOMAINInterPro annotationAdd
BLAST
Domaini391 – 42838EGF-likeInterPro annotationAdd
BLAST
Domaini433 – 606174LAM_G_DOMAINInterPro annotationAdd
BLAST
Domaini620 – 795176LAM_G_DOMAINInterPro annotationAdd
BLAST
Domaini798 – 83538EGF-likeInterPro annotationAdd
BLAST

Keywords - Domaini

EGF-like domainUniRule annotation, RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG3514. Eukaryota.
ENOG410XNU6. LUCA.
GeneTreeiENSGT00760000118991.

Family and domain databases

Gene3Di2.60.120.200. 4 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR029824. Neurexin-1.
[Graphical view]
PANTHERiPTHR10127:SF565. PTHR10127:SF565. 1 hit.
PfamiPF00008. EGF. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 3 hits.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00282. LamG. 4 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 4 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 2 hits.
PS50025. LAM_G_DOMAIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5GYC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GKEEYIATFK GSEYFCYDLS QNPIQSSSDE ITLSFKTLQR NGLMLHTGKS
60 70 80 90 100
ADYVNLALKN GAVSLVINLG SGAFEALVEP VNGKFNDNAW HDVKVTRNLR
110 120 130 140 150
QVTISVDGIL TTTGYTQEDY TMLGSDDFFY VGGSPSTADL PGSPVSNNFM
160 170 180 190 200
GCLKEVVYKN NDVRLELSRL AKQGDPKMKI HGVVAFKCEN VATLDPITFE
210 220 230 240 250
TPESFISLPK WNAKKTGSIS FDFRTTEPNG LILFSHGKPR HQKDAKHPQM
260 270 280 290 300
IKVDFFAIEM LDGHLYLLLD MGSGTIKIKA LLKKVNDGEW YHVDFQRDGR
310 320 330 340 350
SGTISVNTLR TPYTAPGESE ILDLDDELYL GGLPENKAGL VFPTEVWTAL
360 370 380 390 400
LNYGYVGCIR DLFIDGQSKD IRQMAEVQST AGVKPSCSKE TAKPCLSNPC
410 420 430 440 450
KNNGMCRDGW NRYVCDCSGT GYLGRSCERE ATVLSYDGSM FMKIQLPVVM
460 470 480 490 500
HTEAEDVSLR FRSQRAYGIL MATTSRDSAD TLRLELDAGR VKLTVNLDCI
510 520 530 540 550
RINCNSSKGP ETLFAGYNLN DNEWHTVRVV RRGKSLKLTV DDQQAMTGQM
560 570 580 590 600
AGDHTRLEFH NIETGIITER RYLSSVPSNF IGHLQSLTFN GMAYIDLCKN
610 620 630 640 650
GDIDYCELNA RFGFRNIIAD PVTFKTKSSY VALATLQAYT SMHLFFQFKT
660 670 680 690 700
TSLDGLILYN SGDGNDFIVV ELVKGYLHYV FDLGNGANLI KGSSNKPLND
710 720 730 740 750
NQWHNVMISR DTSNLHTVKI DTKITTQITA GARNLDLKSD LYIGGVAKET
760 770 780 790 800
YKSLPKLVHA KEGFQGCLAS VDLNGRLPDL ISDALFCNGQ IERGCEGPST
810 820 830
TCQEDSCSNQ GVCLQQWDGF SCDCSMTSFS GPLCND
Length:836
Mass (Da):92,553
Last modified:October 29, 2014 - v2
Checksum:iAC8BD83A32B37A03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007462 Genomic DNA. No translation available.
AC007560 Genomic DNA. No translation available.
AC007680 Genomic DNA. No translation available.
AC007682 Genomic DNA. No translation available.
AC009234 Genomic DNA. No translation available.
AC010721 Genomic DNA. No translation available.
AC068715 Genomic DNA. No translation available.
AC068725 Genomic DNA. No translation available.
AC069550 Genomic DNA. No translation available.
AC078994 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000402717; ENSP00000385434; ENSG00000179915.
UCSCiuc061jbp.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007462 Genomic DNA. No translation available.
AC007560 Genomic DNA. No translation available.
AC007680 Genomic DNA. No translation available.
AC007682 Genomic DNA. No translation available.
AC009234 Genomic DNA. No translation available.
AC010721 Genomic DNA. No translation available.
AC068715 Genomic DNA. No translation available.
AC068725 Genomic DNA. No translation available.
AC069550 Genomic DNA. No translation available.
AC078994 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliF5GYC7.
SMRiF5GYC7. Positions 2-836.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000385142.

Proteomic databases

PaxDbiF5GYC7.
PeptideAtlasiF5GYC7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000402717; ENSP00000385434; ENSG00000179915.
UCSCiuc061jbp.1. human.

Organism-specific databases

HGNCiHGNC:8008. NRXN1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3514. Eukaryota.
ENOG410XNU6. LUCA.
GeneTreeiENSGT00760000118991.

Miscellaneous databases

ChiTaRSiNRXN1. human.

Gene expression databases

BgeeiF5GYC7.
ExpressionAtlasiF5GYC7. baseline and differential.

Family and domain databases

Gene3Di2.60.120.200. 4 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR029824. Neurexin-1.
[Graphical view]
PANTHERiPTHR10127:SF565. PTHR10127:SF565. 1 hit.
PfamiPF00008. EGF. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 3 hits.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00282. LamG. 4 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 4 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 2 hits.
PS50025. LAM_G_DOMAIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiF5GYC7_HUMAN
AccessioniPrimary (citable) accession number: F5GYC7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: October 29, 2014
Last modified: July 6, 2016
This is version 43 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.