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Protein
Submitted name:

Neurexin-1-beta

Gene

NRXN1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Neurexin-1-betaImported
Gene namesi
Name:NRXN1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000179915.21
HGNCiHGNC:8008 NRXN1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179915

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlasiF5GYC7
PRIDEiF5GYC7

Expressioni

Gene expression databases

BgeeiENSG00000179915
ExpressionAtlasiF5GYC7 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF5GYC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 188LAM_G_DOMAINInterPro annotationAdd BLAST183
Domaini195 – 387LAM_G_DOMAINInterPro annotationAdd BLAST193
Domaini391 – 428EGF-likeInterPro annotationAdd BLAST38
Domaini433 – 606LAM_G_DOMAINInterPro annotationAdd BLAST174
Domaini620 – 795LAM_G_DOMAINInterPro annotationAdd BLAST176
Domaini798 – 835EGF-likeInterPro annotationAdd BLAST38

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG3514 Eukaryota
ENOG410XNU6 LUCA
GeneTreeiENSGT00760000118991

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF02210 Laminin_G_2, 4 hits
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00282 LamG, 4 hits
SUPFAMiSSF49899 SSF49899, 4 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS50026 EGF_3, 2 hits
PS50025 LAM_G_DOMAIN, 4 hits

Sequencei

Sequence statusi: Complete.

F5GYC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GKEEYIATFK GSEYFCYDLS QNPIQSSSDE ITLSFKTLQR NGLMLHTGKS
60 70 80 90 100
ADYVNLALKN GAVSLVINLG SGAFEALVEP VNGKFNDNAW HDVKVTRNLR
110 120 130 140 150
QVTISVDGIL TTTGYTQEDY TMLGSDDFFY VGGSPSTADL PGSPVSNNFM
160 170 180 190 200
GCLKEVVYKN NDVRLELSRL AKQGDPKMKI HGVVAFKCEN VATLDPITFE
210 220 230 240 250
TPESFISLPK WNAKKTGSIS FDFRTTEPNG LILFSHGKPR HQKDAKHPQM
260 270 280 290 300
IKVDFFAIEM LDGHLYLLLD MGSGTIKIKA LLKKVNDGEW YHVDFQRDGR
310 320 330 340 350
SGTISVNTLR TPYTAPGESE ILDLDDELYL GGLPENKAGL VFPTEVWTAL
360 370 380 390 400
LNYGYVGCIR DLFIDGQSKD IRQMAEVQST AGVKPSCSKE TAKPCLSNPC
410 420 430 440 450
KNNGMCRDGW NRYVCDCSGT GYLGRSCERE ATVLSYDGSM FMKIQLPVVM
460 470 480 490 500
HTEAEDVSLR FRSQRAYGIL MATTSRDSAD TLRLELDAGR VKLTVNLDCI
510 520 530 540 550
RINCNSSKGP ETLFAGYNLN DNEWHTVRVV RRGKSLKLTV DDQQAMTGQM
560 570 580 590 600
AGDHTRLEFH NIETGIITER RYLSSVPSNF IGHLQSLTFN GMAYIDLCKN
610 620 630 640 650
GDIDYCELNA RFGFRNIIAD PVTFKTKSSY VALATLQAYT SMHLFFQFKT
660 670 680 690 700
TSLDGLILYN SGDGNDFIVV ELVKGYLHYV FDLGNGANLI KGSSNKPLND
710 720 730 740 750
NQWHNVMISR DTSNLHTVKI DTKITTQITA GARNLDLKSD LYIGGVAKET
760 770 780 790 800
YKSLPKLVHA KEGFQGCLAS VDLNGRLPDL ISDALFCNGQ IERGCEGPST
810 820 830
TCQEDSCSNQ GVCLQQWDGF SCDCSMTSFS GPLCND
Length:836
Mass (Da):92,553
Last modified:October 29, 2014 - v2
Checksum:iAC8BD83A32B37A03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007462 Genomic DNA No translation available.
AC007560 Genomic DNA No translation available.
AC007680 Genomic DNA No translation available.
AC007682 Genomic DNA No translation available.
AC009234 Genomic DNA No translation available.
AC010721 Genomic DNA No translation available.
AC068715 Genomic DNA No translation available.
AC068725 Genomic DNA No translation available.
AC069550 Genomic DNA No translation available.
AC078994 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000402717; ENSP00000385434; ENSG00000179915
UCSCiuc061jbp.1 human

Similar proteinsi

Entry informationi

Entry nameiF5GYC7_HUMAN
AccessioniPrimary (citable) accession number: F5GYC7
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: October 29, 2014
Last modified: May 23, 2018
This is version 58 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health