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Protein

Tyrosine-protein phosphatase

Gene

PTPN6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotation

Enzyme and pathway databases

SignaLinkiF5GY79.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphataseUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:PTPN6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111679.16.
HGNCiHGNC:9658. PTPN6.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000111679.

PTM / Processingi

Proteomic databases

MaxQBiF5GY79.
PaxDbiF5GY79.
PeptideAtlasiF5GY79.
PRIDEiF5GY79.

Expressioni

Gene expression databases

BgeeiENSG00000111679.
ExpressionAtlasiF5GY79. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF5GY79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 59SH2InterPro annotationAdd BLAST59
Domaini69 – 144SH2InterPro annotationAdd BLAST76

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0790. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00900000140780.

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
InterProiView protein in InterPro
IPR000980. SH2.
IPR036860. SH2_dom_sf.
PfamiView protein in Pfam
PF00017. SH2. 2 hits.
PRINTSiPR00401. SH2DOMAIN.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SUPFAMiSSF55550. SSF55550. 2 hits.
PROSITEiView protein in PROSITE
PS50001. SH2. 2 hits.

Sequencei

Sequence statusi: Fragment.

F5GY79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRVGDQVTH IRIQNSGDFY DLYGGEKFAT LTELVEYYTQ QQGVLQDRDG
60 70 80 90 100
TIIHLKYPLN CSDPTSERWY HGHMSGGQAE TLLQAKGEPW TFLVRESLSQ
110 120 130 140
PGDFVLSVLS DQPKAGPGSP LRVTHIKVMC EGGRYTVGGL ETFD
Length:144
Mass (Da):16,066
Last modified:June 28, 2011 - v1
Checksum:i49AB3BDEBB11931C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei144Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47924 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000542462; ENSP00000440114; ENSG00000111679.
UCSCiuc058kop.1. human.

Similar proteinsi

Entry informationi

Entry nameiF5GY79_HUMAN
AccessioniPrimary (citable) accession number: F5GY79
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: October 25, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported