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Protein

Anoctamin

Gene

ANO2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
AnoctaminUniRule annotation
Gene namesi
Name:ANO2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000047617.14.
HGNCiHGNC:1183. ANO2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei363 – 387HelicalUniRule annotationAdd BLAST25
Transmembranei440 – 456HelicalUniRule annotationAdd BLAST17
Transmembranei535 – 559HelicalUniRule annotationAdd BLAST25
Transmembranei579 – 603HelicalUniRule annotationAdd BLAST25
Transmembranei623 – 644HelicalUniRule annotationAdd BLAST22
Transmembranei749 – 772HelicalUniRule annotationAdd BLAST24
Transmembranei907 – 928HelicalUniRule annotationAdd BLAST22

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000047617.

PTM / Processingi

Proteomic databases

PaxDbiF5GXT3.
PRIDEiF5GXT3.

Expressioni

Gene expression databases

BgeeiENSG00000047617.
ExpressionAtlasiF5GXT3. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliF5GXT3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini91 – 349Anoct_dimerInterPro annotationAdd BLAST259

Sequence similaritiesi

Belongs to the anoctamin family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG2514. Eukaryota.
ENOG410XS4S. LUCA.
GeneTreeiENSGT00760000119015.
OMAiDEDKLTW.
OrthoDBiEOG091G01JF.

Family and domain databases

InterProiView protein in InterPro
IPR032394. Anoct_dimer.
IPR007632. Anoctamin.
IPR031288. Anoctamin-2.
PANTHERiPTHR12308. PTHR12308. 1 hit.
PTHR12308:SF20. PTHR12308:SF20. 1 hit.
PfamiView protein in Pfam
PF16178. Anoct_dimer. 1 hit.
PF04547. Anoctamin. 1 hit.

Sequencei

Sequence statusi: Complete.

F5GXT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPGPRDIP LLPGSPRRLS PQAGSRGGQG PKHGQQCLKM PGPRAPGLQG
60 70 80 90 100
GSNRDPGQPC GGESTRSSSV INNYLDANEP VSLEARLSRM HFHDSQRKVD
110 120 130 140 150
YVLAYHYRKR GVHLAQGFPG HSLAIVSNGE TGKEPHAGGP GDIELGPLDA
160 170 180 190 200
LEEERKEQRE EFEHNLMEAG LELEKDLENK SQGSIFVRIH APWQVLAREA
210 220 230 240 250
EFLKIKVPTK KEMYEIKAGG SIAKKFSAAL QKLSSHLQPR VPEHSNNKMK
260 270 280 290 300
NLSYPFSREK MYLYNIQEKD TFFDNATRSR IVHEILKRTA CSRANNTMGI
310 320 330 340 350
NSLIANNIYE AAYPLHDGEY DSPEDDMNDR KLLYQEWARY GVFYKFQPID
360 370 380 390 400
LIRKYFGEKI GLYFAWLGLY TSFLIPSSVI GVIVFLYGCA TIEEDIPSRE
410 420 430 440 450
MCDQQNAFTM CPLCDKSCDY WNLSSACGTA QASHLFDNPA TVFFSIFMAL
460 470 480 490 500
WATMFLENWK RLQMRLGYFW DLTGIEEEEV SSQEHSRPEY ETKVREKMLK
510 520 530 540 550
ESNQSAVQKL ETNTTECGDE DDEDKLTWKD RFPGYLMNFA SILFMIALTF
560 570 580 590 600
SIVFGVIVYR ITTAAALSLN KATRSNVRVT VTATAVIINL VVILILDEIY
610 620 630 640 650
GAVAKWLTKI EVPKTEQTFE ERLILKAFLL KFVNAYSPIF YVAFFKGRFV
660 670 680 690 700
GRPGSYVYVF DGYRMEECAP GGCLMELCIQ LSIIMLGKQL IQNNIFEIGV
710 720 730 740 750
PKLKKLFRKL KDETEAGETD SAHSKHPEQW DLDYSLEPYT GLTPEYMEMI
760 770 780 790 800
IQFGFVTLFV ASFPLAPVFA LLNNVIEVRL DAKKFVTELR RPDAVRTKDI
810 820 830 840 850
GIWFDILSGI GKFSVISNAF VIAITSDFIP RLVYQYSYSH NGTLHGFVNH
860 870 880 890 900
TLSFFNVSQL KEGTQPENSQ FDQEVQFCRF KDYREPPWAP NPYEFSKQYW
910 920 930 940 950
FILSARLAFV IIFQNLVMFL SVLVDWMIPD IPTDISDQIK KEKSLLVDFF
960 970 980 990 1000
LKEEHEKLKL MDEPALRSPG GGDRSRSRAA SSAPSGQSQL GSMMSSGSQH

TNV
Length:1,003
Mass (Da):113,886
Last modified:October 29, 2014 - v2
Checksum:i3295146A13805AC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006431 Genomic DNA. No translation available.
AC006560 Genomic DNA. No translation available.
AC137627 Genomic DNA. No translation available.
KF455597 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000546188; ENSP00000440981; ENSG00000047617.
UCSCiuc058kbj.1. human.

Similar proteinsi

Entry informationi

Entry nameiF5GXT3_HUMAN
AccessioniPrimary (citable) accession number: F5GXT3
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: October 29, 2014
Last modified: October 25, 2017
This is version 46 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported