ID   Q2MD59_HUMAN            Unreviewed;       299 AA.
AC   Q2MD59; F5GXS1;
DT   21-FEB-2006, integrated into UniProtKB/TrEMBL.
DT   21-FEB-2006, sequence version 1.
DT   27-MAR-2024, entry version 106.
DE   SubName: Full=B cell linker {ECO:0000313|Ensembl:ENSP00000391924.3};
DE   SubName: Full=B-cell linker protein {ECO:0000313|EMBL:CAJ55321.1};
DE   Flags: Fragment;
GN   Name=BLNK {ECO:0000313|EMBL:CAJ55321.1,
GN   ECO:0000313|Ensembl:ENSP00000391924.3};
GN   Synonyms=BASH {ECO:0000313|EMBL:CAJ55321.1}, SLP65
GN   {ECO:0000313|EMBL:CAJ55321.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CAJ55321.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000391924.3, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0000313|EMBL:CAJ55321.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=16568084; DOI=10.1038/sj.onc.1209510;
RA   Sprangers M., Feldhahn N., Herzog S., Hansmann M.L., Reppel M.,
RA   Hescheler J., Jumaa H., Siebert R., Muschen M.;
RT   "The SRC family kinase LYN redirects B cell receptor signaling in human
RT   SLP65-deficient B cell lymphoma cells.";
RL   Oncogene 25:5056-5062(2006).
RN   [3] {ECO:0000313|Ensembl:ENSP00000391924.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AC021037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455281; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF573679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AM180327; CAJ55321.1; -; mRNA.
DR   RefSeq; NP_001245371.1; NM_001258442.1.
DR   ProteomicsDB; 24505; -.
DR   Antibodypedia; 3990; 879 antibodies from 42 providers.
DR   DNASU; 29760; -.
DR   Ensembl; ENST00000427367.6; ENSP00000391924.3; ENSG00000095585.18.
DR   GeneID; 29760; -.
DR   UCSC; uc001klv.5; human.
DR   CTD; 29760; -.
DR   HGNC; HGNC:14211; BLNK.
DR   VEuPathDB; HostDB:ENSG00000095585; -.
DR   GeneTree; ENSGT00940000155715; -.
DR   BioGRID-ORCS; 29760; 19 hits in 1150 CRISPR screens.
DR   ChiTaRS; BLNK; human.
DR   GenomeRNAi; 29760; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000095585; Expressed in tongue squamous epithelium and 173 other cell types or tissues.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   PANTHER; PTHR14098:SF3; B-CELL LINKER PROTEIN; 1.
DR   PANTHER; PTHR14098; SH2 DOMAIN CONTAINING PROTEIN; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|MaxQB:Q2MD59,
KW   ECO:0007829|PeptideAtlas:Q2MD59};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   REGION          36..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..76
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        151..166
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CAJ55321.1"
SQ   SEQUENCE   299 AA;  32998 MW;  827C7D4AD2FB5048 CRC64;
     MDKLNKITVP ASQKLRQLQK MVHDIKNNEG GIMNKIKKLK VKAPPSVPRR DYASESPADE
     EEQWSDDFDS DYENPDEHSD SEMYVMPAEE NADDSYEPPP VEQETRPVHP ALPFARGTAS
     GRNSGAWETK SPPPAAPSPL PRAGKKPTTP LKTTPVASQQ NASSVCEEKP IPAERHRGSS
     HRQEAVQSPV FPPAQKQIHQ KPIPLPRFTE GGNPTVDGPL PSFSSNSTIS EQEAGVLCKP
     WYAGACDRKS AEEALHRSNK YFGSVAEIIR NHQHSPLVLI DSQNNTKDST RLKYAVKVS
//