ID   F5GXP1_HUMAN            Unreviewed;       183 AA.
AC   F5GXP1;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   SubName: Full=Alpha-2-macroglobulin like 1 {ECO:0000313|Ensembl:ENSP00000440057.1};
DE   Flags: Fragment;
GN   Name=A2ML1 {ECO:0000313|Ensembl:ENSP00000440057.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000440057.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000440057.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RG   Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA   Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA   Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA   Song X.Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA   Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA   Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA   Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA   Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA   Nguyen B.V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.,
RA   Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA   Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA   Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA   Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA   David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA   D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA   Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA   Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA   Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA   LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA   Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA   Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA   Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA   Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA   Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA   Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA   Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA   Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA   Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA   Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA   Gibbs R.A., null.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000440057.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AC006513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC006581; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; F5GXP1; -.
DR   SMR; F5GXP1; -.
DR   MassIVE; F5GXP1; -.
DR   PeptideAtlas; F5GXP1; -.
DR   PRIDE; F5GXP1; -.
DR   ProteomicsDB; 24480; -.
DR   Antibodypedia; 23090; 137 antibodies from 18 providers.
DR   Ensembl; ENST00000545692.1; ENSP00000440057.1; ENSG00000166535.20.
DR   UCSC; uc058kyf.1; human.
DR   HGNC; HGNC:23336; A2ML1.
DR   VEuPathDB; HostDB:ENSG00000166535; -.
DR   GeneTree; ENSGT00940000163018; -.
DR   HOGENOM; CLU_1478291_0_0_1; -.
DR   ChiTaRS; A2ML1; human.
DR   Proteomes; UP000005640; Chromosome 12.
DR   Bgee; ENSG00000166535; Expressed in lower esophagus mucosa and 116 other cell types or tissues.
DR   ExpressionAtlas; F5GXP1; baseline and differential.
DR   Gene3D; 2.60.40.1930; -; 1.
DR   Gene3D; 6.20.50.160; -; 1.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   PANTHER; PTHR11412:SF178; ALPHA-2-MACROGLOBULIN-LIKE PROTEIN 1; 1.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   SMART; SM01359; A2M_N_2; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|MaxQB:F5GXP1,
KW   ECO:0007829|PeptideAtlas:F5GXP1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN          2..113
FT                   /note="Alpha-2-macroglobulin bait region"
FT                   /evidence="ECO:0000259|SMART:SM01359"
FT   NON_TER         183
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000440057.1"
SQ   SEQUENCE   183 AA;  20170 MW;  19C22090E24668A4 CRC64;
     MLGELIGKGS LVMEGQKHLN SKKKGLKASF SLSLTFTSRL APDPSLVIYA IFPSGGVVAD
     KIQFSVEMCF DNQVSLGFSP SQQLPGAEVE LQLQAAPGSL CALRAVDESV LLLRPDRELS
     NRSVYGMFPF WYGHYPYQVA EYDQCPVSGP WDFPQPLIDP MPQGHSSQRS IIWRPSFSEG
     TDL
//