ID   F5GXA4_HUMAN            Unreviewed;      1002 AA.
AC   F5GXA4;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   27-MAR-2024, entry version 70.
DE   SubName: Full=Stereocilin {ECO:0000313|Ensembl:ENSP00000440413.1};
GN   Name=STRC {ECO:0000313|Ensembl:ENSP00000440413.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000440413.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000440413.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S.,
RA   Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R.,
RA   Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000440413.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AC011330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; F5GXA4; -.
DR   MassIVE; F5GXA4; -.
DR   PeptideAtlas; F5GXA4; -.
DR   ProteomicsDB; 24362; -.
DR   Antibodypedia; 56334; 29 antibodies from 8 providers.
DR   Ensembl; ENST00000541030.5; ENSP00000440413.1; ENSG00000242866.10.
DR   UCSC; uc059ilg.1; human.
DR   HGNC; HGNC:16035; STRC.
DR   VEuPathDB; HostDB:ENSG00000242866; -.
DR   GeneTree; ENSGT00950000182957; -.
DR   HOGENOM; CLU_012151_0_0_1; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000242866; Expressed in right hemisphere of cerebellum and 114 other cell types or tissues.
DR   ExpressionAtlas; F5GXA4; baseline and differential.
DR   InterPro; IPR026664; Stereocilin-rel.
DR   InterPro; IPR048992; Stereocilin_LRR.
DR   PANTHER; PTHR23412; STEREOCILIN RELATED; 1.
DR   PANTHER; PTHR23412:SF14; STEREOCILIN-RELATED; 1.
DR   Pfam; PF21058; Stereocilin; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN          2..126
FT                   /note="Stereocilin LRR"
FT                   /evidence="ECO:0000259|Pfam:PF21058"
FT   DOMAIN          149..374
FT                   /note="Stereocilin LRR"
FT                   /evidence="ECO:0000259|Pfam:PF21058"
FT   REGION          125..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1002 AA;  110697 MW;  74ED08E6FDEAD158 CRC64;
     MELLACFSPV LWDLLQREKS VWALQILVQA YLHMPPENLQ QLVLSAEREA AQGFLTLMLQ
     GKLQGKLQVP PSEEQALGRL TALLLQRYPR LTSQLFIDLS PLIPFLAVSD LMRFPPSLLA
     NDSVQQGYRG SEENSLEEDK GLRPMTPRSL AAIRDYSPGM RPEQKEALAK RLLAPELFGE
     VPAWPQELLW AVLPLLPHLP LENFLQLSPH QIQALEDSWP AAGLGPGHAR HVLRSLVNQS
     VQDGEEQVRR LGPLACFLSP EELQSLVPLS DPTGPVERGL LECAANGTLS PEGRVAYELL
     GVLRSSGGAV LSPRELRVWA PLFSQLGLRF LQELSEPQLR AMLPVLQGTS VTPAQAVLLL
     GRLLPRHDLL QLDSLALLAN RRRYWELPWS EQQAQFLWKK MQVPTNLTLR NLQALGTLAG
     GMSCEFLQQI NSMVDFLEVV HMIYQLPTRV RGSLRACIWA ELQRRMAMPE PEWTTVGPEL
     NGLDSKLLLD LPIQLMDRLS NESIMLVVEL VQRAPEQLLA LTPLHQAALA ERALQNLAPK
     ETPVSGEVLE TLGPLVGFLG TESTRQIPLQ ILLSHLSQLQ GFCLGETFAT ELGWLLLQES
     VLGKPELWSQ DEVEQAGRLV FTLSTEAISL IPREALGPET LERLLEKQQS WEQSRVGQLC
     REPQLAAKKA ALVAGVVRPA AEDLPEPVPN CADVRGTFPA AWSATQIAEM ELSDFEDCLT
     LFAGDPGLGP EELRAAMGKA KQLWGPPRGF RPEQILQLGR LLIGLGDREL QELILVDWGV
     LSTLGQIDGW STTQLRIVVS SFLRQSGRHV SHLDFVHLTA LGYTLCGLRP EELQHISSWE
     FSQAALFLGT LHLQCSEEQL EVLAHLLVLP GGFGPISNWG PEIFTEIGTI AAGIPDLALS
     ALLRGQIQGV TPLAISVIPP PKFAVVFSPI QLSSLTSAQA VAVTPEQMAF LSPEQRRAVA
     WAQHEGKESP EQQGRSTAWG LQDWSRPSWS LVLTISFLGH LL
//