ENG

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: EndoglinImported
Gene namesⁱ	Name:ENGImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000106991.13.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3349. ENG.

Subcellular locationⁱ

GO (Gene Ontology) annotation

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	405 – 432	HelicalSequence analysisAdd BLAST		28

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000106991.

OpenTargetsⁱ

ENSG00000106991.

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	F5GX88.
PaxDbⁱ	F5GX88.
PeptideAtlas More...PeptideAtlasⁱ	F5GX88.
PRIDEⁱ	F5GX88.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000106991.
ExpressionAtlasⁱ	F5GX88. baseline and differential.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	F5GX88.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	181 – 352	ZPInterPro annotationAdd BLAST		172

Keywords - Domainⁱ

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410IQ57. Eukaryota. ENOG410YK9H. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063861.

Family and domain databases

InterProⁱ	View protein in InterPro IPR001507. ZP_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00100. Zona_pellucida. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

F5GX88-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLEASQDMGR TLEWRPRTPA LVRGCHLEGV AGHKEAHILR VLPGHSAGPR 
        60         70         80         90        100
TVTVKVELSC APGDLDAVLI LQGPPYVSWL IDANHNMQIW TTGEYSFKIF 
       110        120        130        140        150
PEKNIRGFKL PDTPQGLLGE ARMLNASIVA SFVELPLASI VSLHASSCGG 
       160        170        180        190        200
RLQTSPAPIQ TTPPKDTCSP ELLMSLIQTK CADDAMTLVL KKELVAHLKC 
       210        220        230        240        250
TITGLTFWDP SCEAEDRGDK FVLRSAYSSC GMQVSASMIS NEAVVNILSS 
       260        270        280        290        300
SSPQRKKVHC LNMDSLSFQL GLYLSPHFLQ ASNTIEPGQQ SFVQVRVSPS 
       310        320        330        340        350
VSEFLLQLDS CHLDLGPEGG TVELIQGRAA KGNCVSLLSP SPEGDPRFSF 
       360        370        380        390        400
LLHFYTVPIP KTGTLSCTVA LRPKTGSQDQ EVHRTVFMRL NIISPDLSGC 
       410        420        430        440        450
TSKGLVLPAV LGITFGAFLI GALLTAALWY IYSHTRSPSK REPVVAVAAP 
       460        470 
ASSESSSTNH SIGSTQSTPC STSSMA

Length:476

Mass (Da):51,140

Last modified:June 28, 2011 - v1

Checksum:ⁱB4D81866E71F35F9

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL157935 Genomic DNA. No translation available. AL162586 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001265067.1. NM_001278138.1.
UniGeneⁱ	Hs.76753.

Genome annotation databases

Ensemblⁱ	ENST00000480266; ENSP00000479015; ENSG00000106991.
GeneIDⁱ	2022.
UCSC genome browser More...UCSCⁱ	uc011mam.4. human.

Similar proteinsⁱ

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
F5GX88	P17813 A0A024R878 Q71V36	Homo sapiens (Human)	658	UniRef100_P17813	Cluster: Endoglin	4

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
F5GX88	P17813 A0A024R878 Q71V36 UPI00045DAE5E UPI00075FE302 UPI0004F20CED UPI0005F50729 UPI0005F3DB20 UPI00053363C7 Q5R771 +16	Homo sapiens (Human) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Papio anubis (Olive baboon) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Gorilla gorilla gorilla (Western lowland gorilla) Colobus angolensis palliatus (Peters' Angolan colobus) And more	658	UniRef90_P17813	Cluster: Endoglin	27

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
F5GX88	Q63961 A9Z1A0 UPI000A31A412 UPI000A312B0E UPI000A31A424 Q3UAM9 UPI000A30742B F7A1B4 Q5IRN0 K9IM02 +151	Mus musculus (Mouse) Mus caroli (Ryukyu mouse) (Ricefield mouse) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Desmodus rotundus (Vampire bat) Ochotona princeps (Southern American pika) Castor canadensis (Beaver) Microcebus murinus (Lesser mouse lemur) (Gray Mouse Lemur) Peromyscus maniculatus bairdii (prairie deer mouse) Cervus elaphus hippelaphus (European red deer) Odocoileus virginianus texanus And more	653	UniRef50_Q63961	Cluster: Endoglin	162

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL157935 Genomic DNA. No translation available. AL162586 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001265067.1. NM_001278138.1.
UniGeneⁱ	Hs.76753.

3D structure databases

ProteinModelPortalⁱ	F5GX88.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	F5GX88.
PaxDbⁱ	F5GX88.
PeptideAtlas More...PeptideAtlasⁱ	F5GX88.
PRIDEⁱ	F5GX88.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000480266; ENSP00000479015; ENSG00000106991.
GeneIDⁱ	2022.
UCSC genome browser More...UCSCⁱ	uc011mam.4. human.

Organism-specific databases

CTDⁱ	2022.
EuPathDBⁱ	HostDB:ENSG00000106991.13.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3349. ENG.
Open Targets More...OpenTargetsⁱ	ENSG00000106991.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IQ57. Eukaryota. ENOG410YK9H. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063861.

Miscellaneous databases

ChiTaRSⁱ	ENG. human.
GenomeRNAiⁱ	2022.

Gene expression databases

Bgeeⁱ	ENSG00000106991.
ExpressionAtlasⁱ	F5GX88. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR001507. ZP_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00100. Zona_pellucida. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F5GX88_HUMAN
Accessionⁱ	F5GX88Primary (citable) accession number: F5GX88
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	June 28, 2011
	Last sequence update:	June 28, 2011
	Last modified:	September 27, 2017
	This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - F5GX88 (F5GX88_HUMAN)

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Endoglin

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ