ENG

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: EndoglinImported
Gene namesⁱ	Name:ENGImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000106991.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3349 ENG

Subcellular locationⁱ

GO - Cellular component

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	405 – 432	HelicalSequence analysisAdd BLAST		28

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000106991

OpenTargetsⁱ

ENSG00000106991

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	F5GX88
PeptideAtlas More...PeptideAtlasⁱ	F5GX88
PRIDEⁱ	F5GX88

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000106991
ExpressionAtlasⁱ	F5GX88 baseline and differential

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	F5GX88
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	181 – 352	ZPInterPro annotationAdd BLAST		172

Keywords - Domainⁱ

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410IQ57 Eukaryota ENOG410YK9H LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063861

Family and domain databases

InterProⁱ	View protein in InterPro IPR001507 ZP_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00100 Zona_pellucida, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

F5GX88-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLEASQDMGR TLEWRPRTPA LVRGCHLEGV AGHKEAHILR VLPGHSAGPR 
        60         70         80         90        100
TVTVKVELSC APGDLDAVLI LQGPPYVSWL IDANHNMQIW TTGEYSFKIF 
       110        120        130        140        150
PEKNIRGFKL PDTPQGLLGE ARMLNASIVA SFVELPLASI VSLHASSCGG 
       160        170        180        190        200
RLQTSPAPIQ TTPPKDTCSP ELLMSLIQTK CADDAMTLVL KKELVAHLKC 
       210        220        230        240        250
TITGLTFWDP SCEAEDRGDK FVLRSAYSSC GMQVSASMIS NEAVVNILSS 
       260        270        280        290        300
SSPQRKKVHC LNMDSLSFQL GLYLSPHFLQ ASNTIEPGQQ SFVQVRVSPS 
       310        320        330        340        350
VSEFLLQLDS CHLDLGPEGG TVELIQGRAA KGNCVSLLSP SPEGDPRFSF 
       360        370        380        390        400
LLHFYTVPIP KTGTLSCTVA LRPKTGSQDQ EVHRTVFMRL NIISPDLSGC 
       410        420        430        440        450
TSKGLVLPAV LGITFGAFLI GALLTAALWY IYSHTRSPSK REPVVAVAAP 
       460        470 
ASSESSSTNH SIGSTQSTPC STSSMA

Length:476

Mass (Da):51,140

Last modified:June 28, 2011 - v1

Checksum:ⁱB4D81866E71F35F9

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL157935 Genomic DNA No translation available. AL162586 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001265067.1, NM_001278138.1
UniGeneⁱ	Hs.76753

Genome annotation databases

Ensemblⁱ	ENST00000480266; ENSP00000479015; ENSG00000106991
GeneIDⁱ	2022
UCSC genome browser More...UCSCⁱ	uc011mam.4 human

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
F5GX88	P17813 A0A024R878 Q71V36	Homo sapiens (Human)	658	UniRef100_P17813	Cluster: Endoglin	4

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
F5GX88	P17813 A0A024R878 Q71V36 UPI0005F50729 UPI0005F3DB20 Q5R771 UPI0005F5325B UPI0005F3CC88 UPI00053363C7 UPI000C2B4A6D +30	Homo sapiens (Human) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Colobus angolensis palliatus (Peters' Angolan colobus) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Piliocolobus tephrosceles (Ugandan red Colobus) Gorilla gorilla gorilla (Western lowland gorilla) Pan troglodytes (Chimpanzee) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) And more	658	UniRef90_P17813	Cluster: Endoglin	41

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
F5GX88	P17813 A0A024R878 Q71V36 UPI0005F50729 UPI0005F3DB20 UPI00053363C7 UPI000C2B4A6D UPI0005F5325B UPI0005F3CC88 Q5R771 +177	Homo sapiens (Human) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Piliocolobus tephrosceles (Ugandan red Colobus) Colobus angolensis palliatus (Peters' Angolan colobus) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Gorilla gorilla gorilla (Western lowland gorilla) Macaca mulatta (Rhesus macaque) Macaca nemestrina (Pig-tailed macaque) And more	658	UniRef50_P17813	Cluster: Endoglin	188

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL157935 Genomic DNA No translation available. AL162586 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001265067.1, NM_001278138.1
UniGeneⁱ	Hs.76753

3D structure databases

ProteinModelPortalⁱ	F5GX88
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	F5GX88
PeptideAtlas More...PeptideAtlasⁱ	F5GX88
PRIDEⁱ	F5GX88

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000480266; ENSP00000479015; ENSG00000106991
GeneIDⁱ	2022
UCSC genome browser More...UCSCⁱ	uc011mam.4 human

Organism-specific databases

CTDⁱ	2022
EuPathDBⁱ	HostDB:ENSG00000106991.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3349 ENG
Open Targets More...OpenTargetsⁱ	ENSG00000106991
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IQ57 Eukaryota ENOG410YK9H LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063861

Miscellaneous databases

ChiTaRSⁱ	ENG human
GenomeRNAiⁱ	2022

Gene expression databases

Bgeeⁱ	ENSG00000106991
ExpressionAtlasⁱ	F5GX88 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR001507 ZP_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00100 Zona_pellucida, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F5GX88_HUMAN
Accessionⁱ	F5GX88Primary (citable) accession number: F5GX88
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	June 28, 2011
	Last sequence update:	June 28, 2011
	Last modified:	March 28, 2018
	This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - F5GX88 (F5GX88_HUMAN)

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Endoglin

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ