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F5GX88

- F5GX88_HUMAN

UniProt

F5GX88 - F5GX88_HUMAN

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Protein
Submitted name:

Endoglin

Gene

ENG

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

GO - Biological processi

  1. artery morphogenesis Source: Ensembl
  2. bone development Source: Ensembl
  3. cell migration involved in endocardial cushion formation Source: Ensembl
  4. cellular response to mechanical stimulus Source: Ensembl
  5. chronological cell aging Source: Ensembl
  6. extracellular matrix constituent secretion Source: Ensembl
  7. heart looping Source: Ensembl
  8. patterning of blood vessels Source: Ensembl
  9. positive regulation of collagen biosynthetic process Source: Ensembl
  10. positive regulation of gene expression Source: Ensembl
  11. positive regulation of protein phosphorylation Source: Ensembl
  12. regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  13. response to corticosteroid Source: Ensembl
  14. response to statin Source: Ensembl
  15. response to transforming growth factor beta Source: Ensembl
  16. smooth muscle tissue development Source: Ensembl
  17. vasculogenesis Source: Ensembl
  18. venous blood vessel morphogenesis Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
EndoglinImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:ENGImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:3349. ENG.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. endothelial microparticle Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiF5GX88. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF5GX88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000063861.
KOiK06526.

Family and domain databases

InterProiIPR001507. ZP_dom.
[Graphical view]
PfamiPF00100. Zona_pellucida. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5GX88-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLEASQDMGR TLEWRPRTPA LVRGCHLEGV AGHKEAHILR VLPGHSAGPR
60 70 80 90 100
TVTVKVELSC APGDLDAVLI LQGPPYVSWL IDANHNMQIW TTGEYSFKIF
110 120 130 140 150
PEKNIRGFKL PDTPQGLLGE ARMLNASIVA SFVELPLASI VSLHASSCGG
160 170 180 190 200
RLQTSPAPIQ TTPPKDTCSP ELLMSLIQTK CADDAMTLVL KKELVAHLKC
210 220 230 240 250
TITGLTFWDP SCEAEDRGDK FVLRSAYSSC GMQVSASMIS NEAVVNILSS
260 270 280 290 300
SSPQRKKVHC LNMDSLSFQL GLYLSPHFLQ ASNTIEPGQQ SFVQVRVSPS
310 320 330 340 350
VSEFLLQLDS CHLDLGPEGG TVELIQGRAA KGNCVSLLSP SPEGDPRFSF
360 370 380 390 400
LLHFYTVPIP KTGTLSCTVA LRPKTGSQDQ EVHRTVFMRL NIISPDLSGC
410 420 430 440 450
TSKGLVLPAV LGITFGAFLI GALLTAALWY IYSHTRSPSK REPVVAVAAP
460 470
ASSESSSTNH SIGSTQSTPC STSSMA
Length:476
Mass (Da):51,140
Last modified:June 28, 2011 - v1
Checksum:iB4D81866E71F35F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157935 Genomic DNA. No translation available.
AL162586 Genomic DNA. No translation available.
RefSeqiNP_001265067.1. NM_001278138.1.
UniGeneiHs.76753.

Genome annotation databases

EnsembliENST00000480266; ENSP00000479015; ENSG00000106991.
ENST00000546301; ENSP00000441083; ENSG00000106991.
GeneIDi2022.
KEGGihsa:2022.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157935 Genomic DNA. No translation available.
AL162586 Genomic DNA. No translation available.
RefSeqi NP_001265067.1. NM_001278138.1.
UniGenei Hs.76753.

3D structure databases

ProteinModelPortali F5GX88.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000480266 ; ENSP00000479015 ; ENSG00000106991 .
ENST00000546301 ; ENSP00000441083 ; ENSG00000106991 .
GeneIDi 2022.
KEGGi hsa:2022.

Organism-specific databases

CTDi 2022.
HGNCi HGNC:3349. ENG.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00530000063861.
KOi K06526.

Miscellaneous databases

ChiTaRSi ENG. human.
GenomeRNAii 2022.
NextBioi 35507353.

Gene expression databases

ExpressionAtlasi F5GX88. baseline and differential.

Family and domain databases

InterProi IPR001507. ZP_dom.
[Graphical view ]
Pfami PF00100. Zona_pellucida. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  3. Ensembl
    Submitted (SEP-2014) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiF5GX88_HUMAN
AccessioniPrimary (citable) accession number: F5GX88
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: October 29, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3