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F5GX88

- F5GX88_HUMAN

UniProt

F5GX88 - F5GX88_HUMAN

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Protein
Submitted name:

Endoglin

Gene

ENG

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi

Display
All None

  • Function
  • Names & Taxonomy
  • Subcellular locationSubcell. location
  • Pathology & BiotechPathol./Biotech
  • PTM / Processing
  • Expression
  • Interaction
  • Structure
  • Family & Domains
  • Sequence
  • Cross-references
  • Publications
  • Entry information
  • Miscellaneous
  • Similar proteins
Top

Functioni

GO - Biological processi

  1. artery morphogenesis Source: Ensembl
  2. bone development Source: Ensembl
  3. cell migration involved in endocardial cushion formation Source: Ensembl
  4. cellular response to mechanical stimulus Source: Ensembl
  5. chronological cell aging Source: Ensembl
  6. extracellular matrix constituent secretion Source: Ensembl
  7. heart looping Source: Ensembl
  8. patterning of blood vessels Source: Ensembl
  9. positive regulation of collagen biosynthetic process Source: Ensembl
  10. positive regulation of gene expression Source: Ensembl
  11. positive regulation of protein phosphorylation Source: Ensembl
  12. regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  13. response to corticosteroid Source: Ensembl
  14. response to statin Source: Ensembl
  15. response to transforming growth factor beta Source: Ensembl
  16. smooth muscle tissue development Source: Ensembl
  17. vasculogenesis Source: Ensembl
  18. venous blood vessel morphogenesis Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
EndoglinImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:ENGImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:3349. ENG.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. endothelial microparticle Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiF5GX88. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF5GX88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000063861.
KOiK06526.

Family and domain databases

InterProiIPR001507. ZP_dom.
[Graphical view]
PfamiPF00100. Zona_pellucida. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5GX88-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLEASQDMGR TLEWRPRTPA LVRGCHLEGV AGHKEAHILR VLPGHSAGPR 
        60         70         80         90        100
TVTVKVELSC APGDLDAVLI LQGPPYVSWL IDANHNMQIW TTGEYSFKIF 
       110        120        130        140        150
PEKNIRGFKL PDTPQGLLGE ARMLNASIVA SFVELPLASI VSLHASSCGG 
       160        170        180        190        200
RLQTSPAPIQ TTPPKDTCSP ELLMSLIQTK CADDAMTLVL KKELVAHLKC 
       210        220        230        240        250
TITGLTFWDP SCEAEDRGDK FVLRSAYSSC GMQVSASMIS NEAVVNILSS 
       260        270        280        290        300
SSPQRKKVHC LNMDSLSFQL GLYLSPHFLQ ASNTIEPGQQ SFVQVRVSPS 
       310        320        330        340        350
VSEFLLQLDS CHLDLGPEGG TVELIQGRAA KGNCVSLLSP SPEGDPRFSF 
       360        370        380        390        400
LLHFYTVPIP KTGTLSCTVA LRPKTGSQDQ EVHRTVFMRL NIISPDLSGC 
       410        420        430        440        450
TSKGLVLPAV LGITFGAFLI GALLTAALWY IYSHTRSPSK REPVVAVAAP 
       460        470 
ASSESSSTNH SIGSTQSTPC STSSMA
Length:476
Mass (Da):51,140
Last modified:June 28, 2011 - v1
Checksum:iB4D81866E71F35F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157935 Genomic DNA. No translation available.
AL162586 Genomic DNA. No translation available.
RefSeqiNP_001265067.1. NM_001278138.1.
UniGeneiHs.76753.

Genome annotation databases

EnsembliENST00000480266; ENSP00000479015; ENSG00000106991.
ENST00000546301; ENSP00000441083; ENSG00000106991.
GeneIDi2022.
KEGGihsa:2022.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
 AL157935 Genomic DNA. No translation available.
AL162586 Genomic DNA. No translation available.
RefSeqi NP_001265067.1. NM_001278138.1.
UniGenei Hs.76753.

3D structure databases

ProteinModelPortali F5GX88.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000480266 ; ENSP00000479015 ; ENSG00000106991 .
ENST00000546301 ; ENSP00000441083 ; ENSG00000106991 .
GeneIDi 2022.
KEGGi hsa:2022.

Organism-specific databases

CTDi 2022.
HGNCi HGNC:3349. ENG.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00530000063861.
KOi K06526.

Miscellaneous databases

ChiTaRSi ENG. human.
GenomeRNAii 2022.
NextBioi 35507353.

Gene expression databases

ExpressionAtlasi F5GX88. baseline and differential.

Family and domain databases

InterProi IPR001507. ZP_dom.
[Graphical view ]
Pfami PF00100. Zona_pellucida. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  3. Ensembl
    Submitted (SEP-2014) to UniProtKB
    Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Entry informationi

Entry nameiF5GX88_HUMAN
AccessioniPrimary (citable) accession number: F5GX88
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: January 7, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.
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