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Protein
Submitted name:

Chromodomain-helicase-DNA-binding protein 4

Gene

CHD4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Chromodomain-helicase-DNA-binding protein 4Imported
Gene namesi
Name:CHD4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:1919. CHD4.

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000111642.

PTM / Processingi

Proteomic databases

EPDiF5GWX5.
MaxQBiF5GWX5.
PaxDbiF5GWX5.
PeptideAtlasiF5GWX5.
PRIDEiF5GWX5.

Expressioni

Gene expression databases

BgeeiENSG00000111642.
ExpressionAtlasiF5GWX5. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiF5GWX5. 6 interactors.
STRINGi9606.ENSP00000349508.

Structurei

3D structure databases

ProteinModelPortaliF5GWX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini363 – 410PHD-typeInterPro annotationAdd BLAST48
Domaini442 – 489PHD-typeInterPro annotationAdd BLAST48
Domaini522 – 579ChromoInterPro annotationAdd BLAST58
Domaini615 – 650ChromoInterPro annotationAdd BLAST36
Domaini731 – 915Helicase ATP-bindingInterPro annotationAdd BLAST185
Domaini1047 – 1196Helicase C-terminalInterPro annotationAdd BLAST150

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1649 – 1670Sequence analysisAdd BLAST22

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG0383. Eukaryota.
COG0553. LUCA.
GeneTreeiENSGT00760000119067.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
3.40.50.300. 2 hits.
InterProiIPR028725. CHD4.
IPR012957. CHD_C2.
IPR012958. CHD_N.
IPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR009462. DUF1086.
IPR009463. DUF1087.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10799:SF554. PTHR10799:SF554. 6 hits.
PfamiPF08074. CHDCT2. 1 hit.
PF08073. CHDNT. 1 hit.
PF00385. Chromo. 1 hit.
PF06461. DUF1086. 1 hit.
PF06465. DUF1087. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00628. PHD. 2 hits.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 2 hits.
SM00487. DEXDc. 1 hit.
SM01146. DUF1086. 1 hit.
SM01147. DUF1087. 1 hit.
SM00490. HELICc. 1 hit.
SM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54160. SSF54160. 3 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50013. CHROMO_2. 2 hits.
PS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS01359. ZF_PHD_1. 2 hits.
PS50016. ZF_PHD_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5GWX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGLGSPSP CSAGSEEEDM DALLNNSLPP PHPENEEDPE EDLSETETPK
60 70 80 90 100
LKKKKKPKKP RDPKIPKSKR QKKELGDSSG EGPEFVEEEE EVALRSDSEG
110 120 130 140 150
SDYTPGKKKK KKLGPKKEKK SKSKRKEEEE EEDDDDDSKE PKSSAQLLED
160 170 180 190 200
WGMEDIDHVF SEEDYRTLTN YKAFSQFVRP LIAAKNPKIA VSKMMMVLGA
210 220 230 240 250
KWREFSTNNP FKGSSGASVA AAAAAAVAVV ESMVTATEVA PPPPPVEVPI
260 270 280 290 300
RKAKTKEGKG PNARRKPKGS PRVPDAKKPK PKKVAPLKIK LGGFGSKRKR
310 320 330 340 350
SSSEDDDLDV ESDFDDASIN SYSVSDGSTS RSSRSRKKLR TTKKKKKGEE
360 370 380 390 400
EVTAVDGYET DHQDYCEVCQ QGGEIILCDT CPRAYHMVCL DPDMEKAPEG
410 420 430 440 450
KWSCPHCEKE GIQWEAKEDN SEGEEILEEV GGDLEEEDDH HMEFCRVCKD
460 470 480 490 500
GGELLCCDTC PSSYHIHCLN PPLPEIPNGE WLCPRCTCPA LKGKVQKILI
510 520 530 540 550
WKWGQPPSPT PVPRPPDADP NTPSPKPLEG RPERQFFVKW QGMSYWHCSW
560 570 580 590 600
VSELQLELHC QVMFRNYQRK NDMDEPPSGD FGGDEEKSRK RKNKDPKFAE
610 620 630 640 650
MEERFYRYGI KPEWMMIHRI LNHSVDKKGH VHYLIKWRDL PYDQASWESE
660 670 680 690 700
DVEIQDYDLF KQSYWNHREL MRGEEGRPGK KLKKVKLRKL ERPPETPTVD
710 720 730 740 750
PTVKYERQPE YLDATGGTLH PYQMEGLNWL RFSWAQGTDT ILADEMGLGK
760 770 780 790 800
TVQTAVFLYS LYKEGHSKGP FLVSAPLSTI INWEREFEMW APDMYVVTYV
810 820 830 840 850
GDKDSRAIIR ENEFSFEDNA IRGGKKASRM KKEASVKFHV LLTSYELITI
860 870 880 890 900
DMAILGSIDW ACLIVDEAHR LKNNQSKFFR VLNGYSLQHK LLLTGTPLQN
910 920 930 940 950
NLEELFHLLN FLTPERFHNL EGFLEEFADI AKEDQIKKLH DMLGPHMLRR
960 970 980 990 1000
LKADVFKNMP SKTELIVRVE LSPMQKKYYK YILTRNFEAL NARGGGNQVS
1010 1020 1030 1040 1050
LLNVVMDLKK CCNHPYLFPV AAMEAPKMPN GMYDGSALIR ASGKLLLLQK
1060 1070 1080 1090 1100
MLKNLKEGGH RVLIFSQMTK MLDLLEDFLE HEGYKYERID GGITGNMRQE
1110 1120 1130 1140 1150
AIDRFNAPGA QQFCFLLSTR AGGLGINLAT ADTVIIYDSD WNPHNDIQAF
1160 1170 1180 1190 1200
SRAHRIGQNK KVMIYRFVTR ASVEERITQV AKKKMMLTHL VVRPGLGSKT
1210 1220 1230 1240 1250
GSMSKQELDD ILKFGTEELF KDEATDGGGD NKEGEDSSVI HYDDKAIERL
1260 1270 1280 1290 1300
LDRNQDETED TELQGMNEYL SSFKVAQYVV REEEMGEEEE VEREIIKQEE
1310 1320 1330 1340 1350
SVDPDYWEKL LRHHYEQQQE DLARNLGKGK RIRKQVNYND GSQEDRDWQD
1360 1370 1380 1390 1400
DQSDNQSDYS VASEEGDEDF DERSEAPRRP SRKGLRNDKD KPLPPLLARV
1410 1420 1430 1440 1450
GGNIEVLGFN ARQRKAFLNA IMRYGMPPQD AFTTQWLVRD LRGKSEKEFK
1460 1470 1480 1490 1500
AYVSLFMRHL CEPGADGAET FADGVPREGL SRQHVLTRIG VMSLIRKKVQ
1510 1520 1530 1540 1550
EFEHVNGRWS MPELAEVEEN KKMSQPGSPS PKTPTPSTPG DTQPNTPAPV
1560 1570 1580 1590 1600
PPAEDGIKIE ENSLKEEESI EGEKEVKSTA PETAIECTQA PAPASEDEKV
1610 1620 1630 1640 1650
VVEPPEGEEK VEKAEVKERT EEPMETEPKG AADVEKVEEK SAIDLTPIVV
1660 1670 1680 1690 1700
EDKEEKKEEE EKKEVMLQNG ETPKDLNDEK QKKNIKQRFM FNIADGGFTE
1710 1720 1730 1740 1750
LHSLWQNEER AATVTKKTYE IWHRRHDYWL LAGIINHGYA RWQDIQNDPR
1760 1770 1780 1790 1800
YAILNEPFKG EMNRGNFLEI KNKFLARRFK LLEQALVIEE QLRRAAYLNM
1810 1820 1830 1840 1850
SEDPSHPSMA LNTRFAEVEC LAESHQHLSK ESMAGNKPAN AVLHKVLKQL
1860 1870 1880 1890 1900
EELLSDMKAD VTRLPATIAR IPPVAVRLQM SERNILSRLA NRAPEPTPQQ

VAQQQ
Length:1,905
Mass (Da):217,103
Last modified:June 28, 2011 - v1
Checksum:iD7B59A71C25EB701
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006064 Genomic DNA. No translation available.
RefSeqiNP_001284482.1. NM_001297553.1.
XP_005253725.1. XM_005253668.3.
UniGeneiHs.162233.

Genome annotation databases

EnsembliENST00000544040; ENSP00000440542; ENSG00000111642.
GeneIDi1108.
UCSCiuc058khn.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006064 Genomic DNA. No translation available.
RefSeqiNP_001284482.1. NM_001297553.1.
XP_005253725.1. XM_005253668.3.
UniGeneiHs.162233.

3D structure databases

ProteinModelPortaliF5GWX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiF5GWX5. 6 interactors.
STRINGi9606.ENSP00000349508.

Proteomic databases

EPDiF5GWX5.
MaxQBiF5GWX5.
PaxDbiF5GWX5.
PeptideAtlasiF5GWX5.
PRIDEiF5GWX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000544040; ENSP00000440542; ENSG00000111642.
GeneIDi1108.
UCSCiuc058khn.1. human.

Organism-specific databases

CTDi1108.
HGNCiHGNC:1919. CHD4.
OpenTargetsiENSG00000111642.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0383. Eukaryota.
COG0553. LUCA.
GeneTreeiENSGT00760000119067.

Miscellaneous databases

ChiTaRSiCHD4. human.
GenomeRNAii1108.

Gene expression databases

BgeeiENSG00000111642.
ExpressionAtlasiF5GWX5. baseline and differential.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
3.40.50.300. 2 hits.
InterProiIPR028725. CHD4.
IPR012957. CHD_C2.
IPR012958. CHD_N.
IPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR009462. DUF1086.
IPR009463. DUF1087.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10799:SF554. PTHR10799:SF554. 6 hits.
PfamiPF08074. CHDCT2. 1 hit.
PF08073. CHDNT. 1 hit.
PF00385. Chromo. 1 hit.
PF06461. DUF1086. 1 hit.
PF06465. DUF1087. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00628. PHD. 2 hits.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 2 hits.
SM00487. DEXDc. 1 hit.
SM01146. DUF1086. 1 hit.
SM01147. DUF1087. 1 hit.
SM00490. HELICc. 1 hit.
SM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54160. SSF54160. 3 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50013. CHROMO_2. 2 hits.
PS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS01359. ZF_PHD_1. 2 hits.
PS50016. ZF_PHD_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF5GWX5_HUMAN
AccessioniPrimary (citable) accession number: F5GWX5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 30, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.