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Protein
Submitted name:

Serine/threonine-protein kinase WNK1

Gene

WNK1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiF5GWT4.

Names & Taxonomyi

Protein namesi
Submitted name:
Serine/threonine-protein kinase WNK1Imported
Gene namesi
Name:WNK1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:14540. WNK1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000060237.

PTM / Processingi

Proteomic databases

EPDiF5GWT4.
MaxQBiF5GWT4.
PaxDbiF5GWT4.
PeptideAtlasiF5GWT4.
PRIDEiF5GWT4.

Expressioni

Gene expression databases

BgeeiENSG00000060237.
ExpressionAtlasiF5GWT4. baseline and differential.
GenevisibleiF5GWT4. HS.

Interactioni

Protein-protein interaction databases

IntActiF5GWT4. 6 interactors.
STRINGi9606.ENSP00000313059.

Structurei

3D structure databases

ProteinModelPortaliF5GWT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini221 – 479Protein kinaseInterPro annotationAdd BLAST259

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili190 – 217Sequence analysisAdd BLAST28
Coiled coili565 – 596Sequence analysisAdd BLAST32

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0584. Eukaryota.
ENOG410XQWZ. LUCA.
GeneTreeiENSGT00800000124049.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR024678. Kinase_OSR1/WNK_CCT.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF12202. OSR1_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5GWT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGAAEKQS STPGSLFLSP PAPAPKNGSS SDSSVGEKLG AAAADAVTGR
60 70 80 90 100
TEEYRRRRHT MDKDSRGAAA TTTTTEHRFF RRSVICDSNA TALELPGLPL
110 120 130 140 150
SLPQPSIPAA VPQSAPPEPH REETVTATAT SQVAQQPPAA AAPGEQAVAG
160 170 180 190 200
PAPSTVPSST SKDRPVSQPS LVGSKEEPPP ARSGSGGGSA KEPQEERSQQ
210 220 230 240 250
QDDIEELETK AVGMSNDGRF LKFDIEIGRG SFKTVYKGLD TETTVEVAWC
260 270 280 290 300
ELQDRKLTKS ERQRFKEEAE MLKGLQHPNI VRFYDSWEST VKGKKCIVLV
310 320 330 340 350
TELMTSGTLK TYLKRFKVMK IKVLRSWCRQ ILKGLQFLHT RTPPIIHRDL
360 370 380 390 400
KCDNIFITGP TGSVKIGDLG LATLKRASFA KSVIGTPEFM APEMYEEKYD
410 420 430 440 450
ESVDVYAFGM CMLEMATSEY PYSECQNAAQ IYRRVTSGVK PASFDKVAIP
460 470 480 490 500
EVKEIIEGCI RQNKDERYSI KDLLNHAFFQ EETGVRVELA EEDDGEKIAI
510 520 530 540 550
KLWLRIEDIK KLKGKYKDNE AIEFSFDLER DVPEDVAQEM VESGYVCEGD
560 570 580 590 600
HKTMAKAIKD RVSLIKRKRE QRQLVREEQE KKKQEESSLK QQVEQSSASQ
610 620 630 640 650
TGIKQLPSAS TGIPTASTTS ASVSTQVEPE EPEADQHQQL QYQQPSISVL
660 670 680 690 700
SDGTVDSGQG SSVFTESRVS SQQTVSYGSQ HEQAHSTGTV PGHIPSTVQA
710 720 730 740 750
QSQPHGVYPP SSVAQGQSQG QPSSSSLTGV SSSQPIQHPQ QQGIQQTAPP
760 770 780 790 800
QQTVQYSLSQ TSTSSEATTA QPVSQPQAPQ VLPQVSAGKQ STQGVSQVAP
810 820 830 840 850
AEPVAVAQTQ ATQPTTLASS VDSAHSDVAS GMSDGNENVP SSSGRHEGRT
860 870 880 890 900
TKRHYRKSVR SRSRHEKTSR PKLRILNVSN KGDRVVECQL ETHNRKMVTF
910 920 930 940 950
KFDLDGDNPE EIATIMVNND FILAIERESF VDQVREIIEK ADEMLSEDVS
960 970 980 990 1000
VEPEGDQGLE SLQGKDDYGF SGSQKLEGEF KQPIPASSMP QQIGIPTSSL
1010 1020 1030 1040 1050
TQVVHSAGRR FIVSPVPESR LRESKVFPSE ITDTVAASTA QSPGMNLSHS
1060 1070 1080 1090 1100
ASSLSLQQAF SELRRAQMTE GPNTAPPNFS HTGPTFPVVP PFLSSIAGVP
1110 1120 1130 1140 1150
TTAAATAPVP ATSSPPNDIS TSVIQSEVTV PTEEGIAGVA TSTGVVTSGG
1160 1170 1180 1190 1200
LPIPPVSESP VLSSVVSSIT IPAVVSISTT SPSLQVPTST SEIVVSSTAL
1210 1220 1230 1240 1250
YPSVTVSATS ASAGGSTATP GPKPPAVVSQ QAAGSTTVGA TLTSVSTTTS
1260 1270 1280 1290 1300
FPSTASQLCI QLSSSTSTPT LAETVVVSAH SLDKTSHSST TGLAFSLSAP
1310 1320 1330 1340 1350
SSSSSPGAGV SSYISQPGGL HPLVIPSVIA STPILPQAAG PTSTPLLPQV
1360 1370 1380 1390 1400
PSIPPLVQPV ANVPAVQQTL IHSQPQPALL PNQPHTHCPE VDSDTQPKAP
1410 1420 1430 1440 1450
GIDDIKTLEE KLRSLFSEHS SSGAQHASVS LETSLVIEST VTPGIPTTAV
1460 1470 1480 1490 1500
APSKLLTSTT STCLPPTNLP LGTVALPVTP VVTPGQVSTP VSTTTSGVKP
1510 1520 1530 1540 1550
GTAPSKPPLT KAPVLPVGTE LPAGTLPSEQ LPPFPGPSLT QSQQPLEDLD
1560 1570 1580 1590 1600
AQLRRTLSPE MITVTSAVGP VSMAAPTAIT EAGTQPQKVS QVKEGPVLAT
1610 1620 1630 1640 1650
SSGAGVFKMG RFQVSVAADG AQKEGKNKSE DAKSVHFESS TSESSVLSSS
1660 1670 1680 1690 1700
SPESTLVKPE PNGITIPGIS SDVPESAHKT TASEAKSDTG QPTKVGRFQV
1710 1720 1730 1740 1750
TTTANKVGRF SVSKTEDKIT DTKKEGPVAS PPFMDLEQAV LPAVIPKKEK
1760 1770 1780 1790 1800
PELSEPSHLN GPSSDPEAAF LSRDVDDGSG SPHSPHQLSS KSLPSQNLSQ
1810 1820 1830 1840 1850
SLSNSFNSSY MSSDNESDIE DEDLKLELRR LRDKHLKEIQ DLQSRQKHEI
1860 1870 1880 1890 1900
ESLYTKLGKV PPAVIIPPAA PLSGRRRRPT KSKGSKSSRS SSLGNKSPQL
1910 1920 1930 1940 1950
SGNLSGQSAA SVLHPQQTLH PPGNIPESGQ NQLLQPLKPS PSSDNLYSAF
1960 1970 1980 1990 2000
TSDGAISVPS LSAPGQGTSS TNTVGATVNS QAAQAQPPAM TSSRKGTFTD
2010 2020 2030 2040 2050
DLHKLVDNWA RDAMNLSGRR GSKGHMNYEG PGMARKFSAP GQLCISMTSN
2060 2070 2080 2090 2100
LGGSAPISAA SATSLGHFTK SMCPPQQYGF PATPFGAQWS GTGGPAPQPL
2110 2120 2130
GQFQPVGTAS LQNFNISNLQ KSISNPPGSN LRTT
Length:2,134
Mass (Da):225,503
Last modified:June 28, 2011 - v1
Checksum:iF76C796F8C41A305
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004765 Genomic DNA. No translation available.
AC004803 Genomic DNA. No translation available.
RefSeqiNP_055638.2. NM_014823.2.
UniGeneiHs.744906.

Genome annotation databases

EnsembliENST00000535572; ENSP00000441972; ENSG00000060237.
GeneIDi65125.
UCSCiuc001qip.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004765 Genomic DNA. No translation available.
AC004803 Genomic DNA. No translation available.
RefSeqiNP_055638.2. NM_014823.2.
UniGeneiHs.744906.

3D structure databases

ProteinModelPortaliF5GWT4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiF5GWT4. 6 interactors.
STRINGi9606.ENSP00000313059.

Proteomic databases

EPDiF5GWT4.
MaxQBiF5GWT4.
PaxDbiF5GWT4.
PeptideAtlasiF5GWT4.
PRIDEiF5GWT4.

Protocols and materials databases

DNASUi65125.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000535572; ENSP00000441972; ENSG00000060237.
GeneIDi65125.
UCSCiuc001qip.5. human.

Organism-specific databases

CTDi65125.
HGNCiHGNC:14540. WNK1.
OpenTargetsiENSG00000060237.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0584. Eukaryota.
ENOG410XQWZ. LUCA.
GeneTreeiENSGT00800000124049.

Enzyme and pathway databases

SignaLinkiF5GWT4.

Miscellaneous databases

ChiTaRSiWNK1. human.
GenomeRNAii65125.

Gene expression databases

BgeeiENSG00000060237.
ExpressionAtlasiF5GWT4. baseline and differential.
GenevisibleiF5GWT4. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR024678. Kinase_OSR1/WNK_CCT.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF12202. OSR1_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF5GWT4_HUMAN
AccessioniPrimary (citable) accession number: F5GWT4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 30, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.