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Protein

Matrix metalloproteinase

Gene

MMP17

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Ca2+UniRule annotation
  • Zn2+UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, MetalloproteaseUniRule annotation, Protease
LigandCalciumUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix metalloproteinaseUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:MMP17Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000198598.6.
HGNCiHGNC:7163. MMP17.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198598.

PTM / Processingi

Keywords - PTMi

ZymogenUniRule annotation

Proteomic databases

PaxDbiF5GWR3.
PeptideAtlasiF5GWR3.
PRIDEiF5GWR3.

Expressioni

Gene expression databases

BgeeiENSG00000198598.
ExpressionAtlasiF5GWR3. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF5GWR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 21PG_binding_1InterPro annotationAdd BLAST21
Domaini48 – 115Peptidase_M10InterPro annotationAdd BLAST68

Sequence similaritiesi

Belongs to the peptidase M10A family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00760000118870.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiView protein in InterPro
IPR024079. MetalloPept_cat_dom.
IPR028726. MMP17.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR002477. Peptidoglycan-bd-like.
PANTHERiPTHR10201:SF194. PTHR10201:SF194. 1 hit.
PfamiView protein in Pfam
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
PRINTSiPR00138. MATRIXIN.
SUPFAMiSSF47090. SSF47090. 1 hit.

Sequencei

Sequence statusi: Fragment.

F5GWR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQFGGLEAT GILDEATLAL MKTPRCSLPD LPVLTQARRR RQAPAPTKWN
60 70 80 90 100
KRNLSWRVRT FPRDSPLGHD TVRALMYYAL KVWSDIAPLN FHEVAGSAAD
110
IQIDFSKADH NDGYP
Length:115
Mass (Da):12,963
Last modified:June 28, 2011 - v1
Checksum:iA599A61179818114
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei115Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131009 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000545790; ENSP00000441710; ENSG00000198598.
UCSCiuc058vgu.1. human.

Similar proteinsi

Entry informationi

Entry nameiF5GWR3_HUMAN
AccessioniPrimary (citable) accession number: F5GWR3
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 27, 2017
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported