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Protein

Matrix metalloproteinase

Gene

MMP17

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Ca2+UniRule annotation
  • Zn2+UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, MetalloproteaseUniRule annotation, Protease
LigandCalciumUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix metalloproteinaseUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:MMP17Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000198598.6.
HGNCiHGNC:7163. MMP17.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198598.

PTM / Processingi

Keywords - PTMi

ZymogenUniRule annotation

Proteomic databases

PeptideAtlasiF5GWR3.
PRIDEiF5GWR3.

Expressioni

Gene expression databases

BgeeiENSG00000198598.
ExpressionAtlasiF5GWR3. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF5GWR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 21PG_binding_1InterPro annotationAdd BLAST21
Domaini48 – 115Peptidase_M10InterPro annotationAdd BLAST68

Sequence similaritiesi

Belongs to the peptidase M10A family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00760000118870.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiView protein in InterPro
IPR024079. MetalloPept_cat_dom_sf.
IPR028726. MMP17.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR002477. Peptidoglycan-bd-like.
IPR036365. PGBD-like_sf.
PANTHERiPTHR10201:SF21. PTHR10201:SF21. 1 hit.
PfamiView protein in Pfam
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
PRINTSiPR00138. MATRIXIN.
SUPFAMiSSF47090. SSF47090. 1 hit.

Sequencei

Sequence statusi: Fragment.

F5GWR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQFGGLEAT GILDEATLAL MKTPRCSLPD LPVLTQARRR RQAPAPTKWN
60 70 80 90 100
KRNLSWRVRT FPRDSPLGHD TVRALMYYAL KVWSDIAPLN FHEVAGSAAD
110
IQIDFSKADH NDGYP
Length:115
Mass (Da):12,963
Last modified:June 28, 2011 - v1
Checksum:iA599A61179818114
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei115Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131009 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000545790; ENSP00000441710; ENSG00000198598.
UCSCiuc058vgu.1. human.

Similar proteinsi

Entry informationi

Entry nameiF5GWR3_HUMAN
AccessioniPrimary (citable) accession number: F5GWR3
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: March 28, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported