F5GWL6 (F5GWL6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
C-C chemokine receptor type 3 Ensembl ENSP00000441600

Gene names

Name:

CCR3 Ensembl ENSP00000441600

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000441600

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the G-protein coupled receptor 1 family. RuleBase RU000688
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000441600

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS000355
Molecular function	G-protein coupled receptor RuleBase RU000688 SAAS SAAS000355 Receptor Transducer
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ERK1 and ERK2 cascade Inferred from electronic annotation. Source: Compara activation of MAPK activity Inferred from electronic annotation. Source: InterPro angioblast cell migration Inferred from electronic annotation. Source: Compara chemokine-mediated signaling pathway Inferred from electronic annotation. Source: GOC elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: InterPro eosinophil chemotaxis Inferred from electronic annotation. Source: Compara mast cell chemotaxis Inferred from electronic annotation. Source: Compara positive regulation of angiogenesis Inferred from electronic annotation. Source: Compara positive regulation of endothelial cell proliferation Inferred from electronic annotation. Source: Compara
Cellular_component	endosome Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: Compara
Molecular_function	C-C chemokine receptor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F5GWL6 [UniParc]. Last modified June 28, 2011. Version 1. Checksum: 422D094FF3497FE4	FASTA	376	43,453
	10 20 30 40 50 60 MPFGIRMLLR AHKPGSSRRS EMTTSLDTVE TFGTTSYYDD VGLLCEKADT RALMAQFVPP 70 80 90 100 110 120 LYSLVFTVGL LGNVVVVMIL IKYRRLRIMT NIYLLNLAIS DLLFLVTLPF WIHYVRGHNW 130 140 150 160 170 180 VFGHGMCKLL SGFYHTGLYS EIFFIILLTI DRYLAIVHAV FALRARTVTF GVITSIVTWG 190 200 210 220 230 240 LAVLAALPEF IFYETEELFE ETLCSALYPE DTVYSWRHFH TLRMTIFCLV LPLLVMAICY 250 260 270 280 290 300 TGIIKTLLRC PSKKKYKAIR LIFVIMAVFF IFWTPYNVAI LLSSYQSILF GNDCERSKHL 310 320 330 340 350 360 DLVMLVTEVI AYSHCCMNPV IYAFVGERFR KYLRHFFHRH LLMHLGRYIP FLPSEKLERT 370 SSVSPSTAEP ELSIVF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC104439 Genomic DNA. No translation available.
IPI	IPI00944675.
RefSeq	NP_847898.1. NM_178328.1.
UniGene	Hs.506190.
3D structure databases
ProteinModelPortal	F5GWL6.
SMR	F5GWL6. Positions 49-344.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	F5GWL6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000545097; ENSP00000441600; ENSG00000183625.
GeneID	1232.
KEGG	hsa:1232.
UCSC	uc003cpk.2. human.
Organism-specific databases
CTD	1232.
HGNC	HGNC:1604. CCR3.
GenAtlas	Search...
Phylogenomic databases
KO	K04178.
OMA	YIPFLPS.
Gene expression databases
ArrayExpress	F5GWL6.
Bgee	F5GWL6.
Family and domain databases
InterPro	IPR002238. Chemokine_CCR3. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR01108. CHEMOKINER3. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1232.
NextBio	5025.

Entry information

Entry name

F5GWL6_HUMAN

Accession

Primary (citable) accession number: F5GWL6

Entry history

Integrated into UniProtKB/TrEMBL:	June 28, 2011
Last sequence update:	June 28, 2011
Last modified:	May 1, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.