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Protein
Submitted name:

Adenosine deaminase

Gene

ADA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Adenosine deaminaseImported
Submitted name:
Adenosine deaminase isoform 2Imported
Gene namesi
Name:ADAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:186. ADA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196839.

PTM / Processingi

Proteomic databases

MaxQBiF5GWI4.
PeptideAtlasiF5GWI4.

Expressioni

Gene expression databases

BgeeiENSG00000196839.
ExpressionAtlasiF5GWI4. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF5GWI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 201A_deaminaseInterPro annotationAdd BLAST193
Domaini202 – 321A_deaminaseInterPro annotationAdd BLAST120

Phylogenomic databases

GeneTreeiENSGT00730000111151.

Family and domain databases

CDDicd01320. ADA. 1 hit.
InterProiIPR006650. A/AMP_deam_AS.
IPR001365. A/AMP_deaminase_dom.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 2 hits.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
PROSITEiPS00485. A_DEAMINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5GWI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQTPAFDKP KVELHVHLDG SIKPETILYY GRRRGIALPA NTAEGLLNVI
60 70 80 90 100
GMDKPLTLPD FLAKFDYYMP AIAGCREAIK RIAYEFVEMK AKEGVVYVEV
110 120 130 140 150
RYSPHLLANS KVEPIPWNQA EGDLTPDEVV ALVGQGLQEG ERDFGVKARS
160 170 180 190 200
ILCCMRHQPN WSPKVVELCK KYQQQTVVAI DLAGDETIPG SSLLPGHVQA
210 220 230 240 250
YQAVDILKTE RLGHGYHTLE DQALYNRLRQ ENMHFEICPW SSYLTGAWKP
260 270 280 290 300
DTEHAVIRLK NDQANYSLNT DDPLIFKSTL DTDYQMTKRD MGFTEEEFKR
310 320 330
LNINAAKSSF LPEDEKRELL DLLYKAYGMP PSASAGQNL
Length:339
Mass (Da):38,293
Last modified:June 28, 2011 - v1
Checksum:i04B0ABF8FDAFF9BF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei339Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139352 Genomic DNA. No translation available.
KF456921 Genomic DNA. No translation available.
Z97053 Genomic DNA. No translation available.
KU177893 mRNA. Translation: ALQ33351.1.
RefSeqiNP_001308980.1. NM_001322051.1.
UniGeneiHs.654536.

Genome annotation databases

EnsembliENST00000537820; ENSP00000441818; ENSG00000196839.
GeneIDi100.
UCSCiuc061xfm.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139352 Genomic DNA. No translation available.
KF456921 Genomic DNA. No translation available.
Z97053 Genomic DNA. No translation available.
KU177893 mRNA. Translation: ALQ33351.1.
RefSeqiNP_001308980.1. NM_001322051.1.
UniGeneiHs.654536.

3D structure databases

ProteinModelPortaliF5GWI4.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiF5GWI4.
PeptideAtlasiF5GWI4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000537820; ENSP00000441818; ENSG00000196839.
GeneIDi100.
UCSCiuc061xfm.1. human.

Organism-specific databases

CTDi100.
HGNCiHGNC:186. ADA.
OpenTargetsiENSG00000196839.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00730000111151.

Miscellaneous databases

ChiTaRSiADA. human.
GenomeRNAii100.

Gene expression databases

BgeeiENSG00000196839.
ExpressionAtlasiF5GWI4. baseline and differential.

Family and domain databases

CDDicd01320. ADA. 1 hit.
InterProiIPR006650. A/AMP_deam_AS.
IPR001365. A/AMP_deaminase_dom.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 2 hits.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
PROSITEiPS00485. A_DEAMINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF5GWI4_HUMAN
AccessioniPrimary (citable) accession number: F5GWI4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 30, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.