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F5BXG7

- F5BXG7_RHDV

UniProt

F5BXG7 - F5BXG7_RHDV

Protein
Submitted name:

Polyprotein

Gene
N/A
Organism
Rabbit hemorrhagic disease virus (RHDV)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    NTP + H2O = NDP + phosphate.SAAS annotation
    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cysteine-type endopeptidase activity Source: InterPro
    3. RNA binding Source: InterPro
    4. RNA-directed RNA polymerase activity Source: UniProtKB-KW
    5. RNA helicase activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro
    2. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseSAAS annotation, Thiol proteaseSAAS annotation, Transferase

    Keywords - Biological processi

    Viral RNA replicationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    PolyproteinImported
    OrganismiRabbit hemorrhagic disease virus (RHDV)Imported
    Taxonomic identifieri11976 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeLagovirus
    Virus hostiOryctolagus cuniculus (Rabbit) [TaxID: 9986]

    Subcellular locationi

    GO - Cellular componenti

    1. viral capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid proteinSAAS annotation, Virion

    PTM / Processingi

    Keywords - PTMi

    PhosphoproteinSAAS annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J1Pelectron microscopy6.50A/B/C1766-2344[»]
    ProteinModelPortaliF5BXG7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains RdRp catalytic domain.SAAS annotation
    Contains SF3 helicase domain.SAAS annotation
    Contains SFhelicase domain.SAAS annotation

    Family and domain databases

    Gene3Di2.60.120.20. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR004005. Calicivirus_coat.
    IPR004004. Helic/Pol/Pept_Calicivir-typ.
    IPR000605. Helicase_SF3_ssDNA/RNA_vir.
    IPR014759. Helicase_SF3_ssRNA_vir.
    IPR027417. P-loop_NTPase.
    IPR000317. Peptidase_C24.
    IPR001205. RNA-dir_pol_C.
    IPR007094. RNA-dir_pol_PSvirus.
    IPR009003. Trypsin-like_Pept_dom.
    IPR029053. Viral_coat.
    [Graphical view]
    PfamiPF00915. Calici_coat. 1 hit.
    PF03510. Peptidase_C24. 1 hit.
    PF00680. RdRP_1. 1 hit.
    PF00910. RNA_helicase. 1 hit.
    [Graphical view]
    PRINTSiPR00916. 2CENDOPTASE.
    PR00918. CALICVIRUSNS.
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
    PS51218. SF3_HELICASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F5BXG7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVMSRPIGT TTAILPEKKP LSFFLDLRDK TPPCCIRATG KLAWPVFLGQ     50
    NENEGPLETC DICGKWLNGF GNFGLEDLGN VCLCSIAQQK HKFGPVCLCN 100
    RAYIHDCGRW RRRSRFLKHY KALNKVIPCA YRFDEGSSPP VFEGEVDDLF 150
    VELGAPTSMG FMDKKLLKKG KKLMDKFVDV DEPCLTSRDA GLLDSIASDN 200
    TIRAKLEEEY GVEMVQAARD RKDFMKNLRL ALDNRPANPV TWHTKLGNIT 250
    DKGKQWAKKV VYGACKVTEP LKTLASILLV GLHNVIAVDT TVMLSTFKPV 300
    NLLAILMDWT NDLAGFVTTL VRLLELYGVV QATVNLIIEG VKSFWDKVIC 350
    ATDRCYDLLK RLFDTFEDSV PTGPTAGCLI FMAFVFSTVV GYLPNNNVIT 400
    TFMKGAGKLT TFAGVIGAIR TLWITINQHM VAKDLTSIQQ KVMTVVKMAN 450
    EAATLGQLEI VSCLCSDLEN TLTNRCTLPS YNQHLGILNA SQKVVSDLHT 500
    MVLGKINMTK QRPQPVAVIF KGAPGIGKTY LVHRIARDLG CQHPSTINFG 550
    LDHFDSYTGE EVAIADEFNT CGDGESWVEL FIQMVNTNPC PLNCDKAENK 600
    NKVFNSKYLL CTTNSNMILN ATHPRAGAFY RRVLIVEARN KAVESWQATR 650
    HGAKPGKSCY NKDMSHLTFQ VYPHSMPAPG FVFVGDKLVK SQVAPREYKY 700
    SELLDLIKSE HPDVASFEGA NKFNFIYPDA QYEQALLMWK QYFVMYGCVA 750
    RLAKSFVDDI PYNQVHISKA SDPKIDGCVE YQCKFQHLWR MVPQFVLGCV 800
    NMTNQLGTPL TQQQLDRITN GVEGVTVTTV NNILPFHSQT TLINPSFIKL 850
    IWAVRKHLKG LSGVTKVAQF IWRVMTNPVD AYGSLVRTLI GAATFSDDPV 900
    STTIICSNCT IQIHSCGGLL VRYSRDPVPV ASDNVDRGDQ GVDVFTDPNL 950
    ISGFSWRQIA HLFVEVISHL CANHLVNLAT MAALGAVATK AFQGVKGKTK 1000
    RGRGARVNLG NDEYDEWQAA RREFVNAHDM TAEEYLAMKN KAAMGSDDQD 1050
    SVMFRSWWTR RQLRPDEDQV TIVGRGGVRN EVIRTRARQA PKGPKILDDG 1100
    GFYDNDYEGL PGFMRHNGSG WMIHIGNGLY ISNTHTARSS CSEIVTCSPT 1150
    TDLCLVKGET IRSVAQIAEG TPVCDWKKSP ISTYGIKKTL SDSTKIDVLA 1200
    YDGCTQTTHG DCGLPLYDSS GKIVAIHTGK LLGFSKMCTL VDLTITKGVY 1250
    ETSNFFCGEP IDYRGITAHR LVGAEPRPPV SGTRYARVPG VPDEYKTGYR 1300
    PANLGRGDPD SDKSLMNIAV KNLQVYQQEP KLDKVDEFIE RAAADVLGYL 1350
    RFLTKGERQA NLNFKAAFNT LDLSTSCGPF VPGKKIDHIK DGVMDQVLAK 1400
    HLYKCWSVAN SGKALHHIYA CGLKDELRPL DKVKEGKKRL LWGCDVGVAV 1450
    CAAAVFHNIC YKLKMVARFG PIAVGVDMTS RDVDVIINNL TAKASDFLCL 1500
    DYSKWDSTMS PCVVRLAIDI LADCCEQTEL TKSVVLTLKS HPMTILDAMI 1550
    VQTKRGLPSG MPFTSVINSI CHWLLWSAAV YKSCAEIGLH CSNLYEDAPF 1600
    YTYGDDGVYA MTPMMVSLLP AIIENLRDYG LSPTAADKTE FIDVCPLSKI 1650
    SFLKRTFELT DIGWVSKLDK SSILRQLEWS KTTSRHMLIE ETYDLAKEER 1700
    GVQLEELQVA AAAHGQEFFS FVRKELERQQ AYTQFSVYSY DAARKILADR 1750
    KRVVSVVPDD EFVNVMEGKA RTAPQGEAAG TATTASVPGT TTDGMDPGVV 1800
    AATSVVTAEN SSASVATAGI GGPPQQVDQQ ETWRTNFYYN DVFTWSVADA 1850
    PGSILYTVQH SPQNNPFTAV LSQMYAGWAG GMQFRFIVAG SGVFGGRLVA 1900
    AVIPPGIEIG PGLEVRQFPH VVIDARSLEP VTITMPDLRP NMYHPTGDPG 1950
    LVPTLVLSVY NNLINPFGGS TNAIQVTVET RPSDDFEFVM IRAPSSKTVD 2000
    SISPAGLITT PVLTGVGNDN RWDGQIVGLQ PVPGGFSTCN RHWNLNGSTY 2050
    GWSSPRFADI DHRRGSASYS GNNSANALQF WYANAGSAID NPISQVAPDG 2100
    FPDMSFVPFN SPNIPTAGWV GFGGIWNSNN GAPAATTVQA YELGFATGAP 2150
    NNLQPTTNTS GAQTVAKSIY AVVTGTNQNP TGLFVMASGV ISTPNASAVT 2200
    YTPQPDRIVT TPGTPAAAPV GKNTPIMFAS VVRRTGDVNA AAGSTNGTQY 2250
    GTGSQPLPVT IGLSLNNYSS ALMPGQFFVW QLTFASGFME IGLSVDGYFY 2300
    AGTGASTTLI DLTELIDVRP VGPRPSKSTL VFNLGGTTNG FSYV 2344
    Length:2,344
    Mass (Da):256,610
    Last modified:June 28, 2011 - v1
    Checksum:iAAA47274D6CC39F3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JF412629 Genomic RNA. Translation: AEB26305.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JF412629 Genomic RNA. Translation: AEB26305.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J1P electron microscopy 6.50 A/B/C 1766-2344 [» ]
    ProteinModelPortali F5BXG7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.120.20. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR004005. Calicivirus_coat.
    IPR004004. Helic/Pol/Pept_Calicivir-typ.
    IPR000605. Helicase_SF3_ssDNA/RNA_vir.
    IPR014759. Helicase_SF3_ssRNA_vir.
    IPR027417. P-loop_NTPase.
    IPR000317. Peptidase_C24.
    IPR001205. RNA-dir_pol_C.
    IPR007094. RNA-dir_pol_PSvirus.
    IPR009003. Trypsin-like_Pept_dom.
    IPR029053. Viral_coat.
    [Graphical view ]
    Pfami PF00915. Calici_coat. 1 hit.
    PF03510. Peptidase_C24. 1 hit.
    PF00680. RdRP_1. 1 hit.
    PF00910. RNA_helicase. 1 hit.
    [Graphical view ]
    PRINTSi PR00916. 2CENDOPTASE.
    PR00918. CALICVIRUSNS.
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
    PS51218. SF3_HELICASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Liu J.S., Liu H.R., Guo D.C., Qu L.D.
      Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: HYDImported.
    2. "Atomic model of rabbit hemorrhagic disease virus by cryo-electron microscopy and crystallography."
      Wang X., Xu F., Liu J., Gao B., Liu Y., Zhai Y., Ma J., Zhang K., Baker T.S., Schulten K., Zheng D., Pang H., Sun F.
      PLoS Pathog. 9:e1003132-e1003132(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY ELECTRON MICROSCOPY (6.50 ANGSTROMS) OF 1766-2344.

    Entry informationi

    Entry nameiF5BXG7_RHDV
    AccessioniPrimary (citable) accession number: F5BXG7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3