F4MB96 (F4MB96_ECOLX) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Amino-acid acetyltransferase HAMAP-Rule MF_01105
EC=2.3.1.- HAMAP-Rule MF_01105
EC=2.3.1.1 HAMAP-Rule MF_01105

Alternative name(s):
N-acetylglutamate synthase HAMAP-Rule MF_01105

Gene names

Name:	argA HAMAP-Rule MF_01105 EMBL AEE58042.1
ORF Names:	UMNK88_3502 EMBL AEE58042.1

Organism

Escherichia coli UMNK88 EMBL AEE58042.1

Taxonomic identifier

696406 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	443 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate. HAMAP-Rule MF_01105 SAAS SAAS000182
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4. HAMAP-Rule MF_01105 SAAS SAAS000182
Subunit structure	Homohexamer By similarity. HAMAP-Rule MF_01105
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_01105 SAAS SAAS000182.
Sequence similarities	Belongs to the acetyltransferase family. ArgA subfamily. HAMAP-Rule MF_01105 Contains 1 N-acetyltransferase domain. HAMAP-Rule MF_01105 SAAS SAAS000182

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis HAMAP-Rule MF_01105 SAAS SAAS000182
Cellular component	Cytoplasm HAMAP-Rule MF_01105 SAAS SAAS000182
Molecular function	Acyltransferase HAMAP-Rule MF_01105 SAAS SAAS000182 Transferase
Gene Ontology (GO)
Biological_process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	acetyl-CoA:L-glutamate N-acetyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Domain	296 – 443	148	N-acetyltransferase By similarity HAMAP-Rule MF_01105

Sequences

	Sequence		Length	Mass (Da)
	F4MB96 [UniParc]. Last modified June 28, 2011. Version 1. Checksum: AE0D84902456797A	FASTA	443	49,195
	10 20 30 40 50 60 MVKERKTELV EGFRHSVPYI NTHRGKTFVI MLGGEAIEHE NFSSIVNDIG LLHSLGIRLV 70 80 90 100 110 120 VVYGARPQID ANLAAHHHEP LYHKNIRVTD AKTLELVKQA AGTLQLDITA RLSMSLNNTP 130 140 150 160 170 180 LQGAHINVVS GNFIIAQPLG VDDGVDYCHS GRIRRIDEDA IHRQLDSGAI VLMGPVAVSV 190 200 210 220 230 240 TGESFNLTSE EIATQLAIKL KAEKMIGFCS SQGVTNDDGD IVSELFPNEA QARVEAQEEK 250 260 270 280 290 300 GDYNSGTVRF LRGAVKACRS GVRRCHLISY QEDGALLQEL FSRDGIGTQI VMESAEQIRR 310 320 330 340 350 360 ATINDIGGIL ELIRPLEQQG ILVRRSREQL EMEIDKFTII QRDNTTIACA ALYPFPEEKI 370 380 390 400 410 420 GEMACVAVHP DYRSSSRGEV LLERIAAQAK QSGLSKLFVL TTRSIHWFQE RGFTPVDIDL 430 440 LPESKKQLYN YQRKSKVLMA DLG

References

[1]	"Genome structure of porcine enterotoxigenic Escherichia coli." Johnson T.J., Shepard S.M., Isaacson R.E. Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: UMNK88 EMBL AEE58042.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002729 Genomic DNA. Translation: AEE58042.1.
RefSeq	YP_006135205.1. NC_017641.1.
3D structure databases
ProteinModelPortal	F4MB96.
SMR	F4MB96. Positions 9-442.
ModBase	Search...
Proteomic databases
PRIDE	F4MB96.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AEE58042; AEE58042; UMNK88_3502.
GeneID	12686766.
KEGG	eun:UMNK88_3502.
PATRIC	48574783. VBIEscCol159162_3438.
Phylogenomic databases
KO	K14682.
OMA	PTGQAFN.
Enzyme and pathway databases
UniPathway	UPA00068; UER00106.
Family and domain databases
Gene3D	3.40.1160.10. 1 hit. 3.40.630.30. 1 hit.
HAMAP	MF_01105. N_acetyl_glu_synth.
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR001048. Asp/Glu/Uridylate_kinase. IPR000182. GNAT_dom. IPR010167. NH2A_AcTrfase_ArgA. [Graphical view]
Pfam	PF00696. AA_kinase. 1 hit. PF00583. Acetyltransf_1. 1 hit. [Graphical view]
PIRSF	PIRSF000423. ArgA. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit. SSF55729. Acyl_CoA_acyltransferase. 1 hit.
TIGRFAMs	TIGR01890. N-Ac-Glu-synth. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F4MB96_ECOLX

Accession

Primary (citable) accession number: F4MB96

Entry history

Integrated into UniProtKB/TrEMBL:	June 28, 2011
Last sequence update:	June 28, 2011
Last modified:	May 1, 2013
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)