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F4LRZ6

- F4LRZ6_TEPAE

UniProt

F4LRZ6 - F4LRZ6_TEPAE

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Protein

Glycerol kinase

Gene

glpK

Organism
Tepidanaerobacter acetatoxydans (strain DSM 21804 / JCM 16047 / Re1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.UniRule annotation

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotationSAAS annotation

Enzyme regulationi

Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111SubstrateUniRule annotation
Binding sitei15 – 151ATPUniRule annotation
Binding sitei264 – 2641ATPUniRule annotation
Binding sitei306 – 3061ATP; via carbonyl oxygenUniRule annotation
Binding sitei310 – 3101ATP; via amide nitrogenUniRule annotation
Binding sitei325 – 3251ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 133ATPUniRule annotation
Nucleotide bindingi407 – 4115ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glycerol kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycerol-3-phosphate metabolic process Source: UniProtKB-HAMAP
  2. glycerol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

Glycerol metabolismUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTSP499229:GHS2-2265-MONOMER.
UniPathwayiUPA00618; UER00672.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinaseUniRule annotation (EC:2.7.1.30UniRule annotation)
Alternative name(s):
ATP:glycerol 3-phosphotransferaseUniRule annotation
GlycerokinaseUniRule annotation
Gene namesi
Name:glpKUniRule annotationImported
Ordered Locus Names:TepiRe1_2381Imported, TepRe1_2213Imported
OrganismiTepidanaerobacter acetatoxydans (strain DSM 21804 / JCM 16047 / Re1)Imported
Taxonomic identifieri1209989 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeTepidanaerobacter
ProteomesiUP000010802: Chromosome

Interactioni

Subunit structurei

Homotetramer and homodimer (in equilibrium).UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF4LRZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni81 – 822Substrate bindingUniRule annotation
Regioni242 – 2432Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the FGGY kinase family.UniRule annotation

Phylogenomic databases

KOiK00864.

Family and domain databases

HAMAPiMF_00186. Glycerol_kin.
InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F4LRZ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRILVIDQG TTGSRAIIFD EHGERLFMEY KEFRQIYPKP GWVEHDPMEI
60 70 80 90 100
WDVTLDVTKR VLANANMSGK DISAIGITNQ RETTTLWDKN TGKPLYNSIV
110 120 130 140 150
WACRRTTDIC QDLISKGYNE IFNKKTGLII DPVYSATKIR WIMDNVDGVK
160 170 180 190 200
EKVDRDEVLF GTIDSWLLWN LTGGNVHATD FSNASRTMLF NVKDIKWDEE
210 220 230 240 250
LLKIMDIPAN MLPEVKPSVG LFGYTDKKLF GKEIPITGIA GDQQAALFGQ
260 270 280 290 300
TCFEEGDTKN TYGTSCVPLM FTGTKPVFTD KGLLTLAWGY NNEVKYSMGA
310 320 330 340 350
SIFTAGSAIQ WLRDNLNLIS SSSETEELAK SVEDNAGVYF VPAFTGLGAP
360 370 380 390 400
HWDMYARGMI IGLTSNATKA HLVRATLESL AYQTRDLLDE IESKSAIKLK
410 420 430 440 450
CLKVDGGAAK NNFLMQFQAD ILNCPVIRPK DIETTSLGAA YMAGLGIGIW
460 470 480 490
KDENEIKQLW KIDKEFYPSM QKDKREELYS NWKHAVEHAR GWLKK
Length:495
Mass (Da):55,718
Last modified:June 28, 2011 - v1
Checksum:i724C5367C8850590
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002728 Genomic DNA. Translation: AEE92335.1.
HF563609 Genomic DNA. Translation: CDI40973.1.
RefSeqiYP_004461642.1. NC_015519.1.
YP_008619215.1. NC_019954.2.

Genome annotation databases

EnsemblBacteriaiAEE92335; AEE92335; TepRe1_2213.
GeneIDi10599002.
17374057.
KEGGitae:TepiRe1_2381.
tep:TepRe1_2213.
PATRICi54627585. VBITepSp18581_2319.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002728 Genomic DNA. Translation: AEE92335.1 .
HF563609 Genomic DNA. Translation: CDI40973.1 .
RefSeqi YP_004461642.1. NC_015519.1.
YP_008619215.1. NC_019954.2.

3D structure databases

ProteinModelPortali F4LRZ6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEE92335 ; AEE92335 ; TepRe1_2213 .
GeneIDi 10599002.
17374057.
KEGGi tae:TepiRe1_2381.
tep:TepRe1_2213.
PATRICi 54627585. VBITepSp18581_2319.

Phylogenomic databases

KOi K00864.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00672 .
BioCyci TSP499229:GHS2-2265-MONOMER.

Family and domain databases

HAMAPi MF_00186. Glycerol_kin.
InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01311. glycerol_kin. 1 hit.
PROSITEi PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of Tepidanaerobacter sp. Re1."
    US DOE Joint Genome Institute
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Pagani I., Teshima H., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Lcollab F.I., Woyke T.
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Re1Imported.
  2. "First Genome Sequence of a Syntrophic Acetate-Oxidizing Bacterium, Tepidanaerobacter acetatoxydans Strain Re1."
    Manzoor S., Bongcam-Rudloff E., Schnurer A., Muller B.
    Genome Announc. 1:e00213-e00212(2013)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Re1Imported.
  3. "First genome sequence of a syntrophic acetate-oxidizing bacterium, Tepidanaerobacter acetatoxydans strain Re1."
    Manzoor S., Bongcam-Rudloff E., Schnurer A., Muller B.
    Genome Announc. 1:E00213-E00213(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiF4LRZ6_TEPAE
AccessioniPrimary (citable) accession number: F4LRZ6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: October 29, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3