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F4LRZ6

- F4LRZ6_TEPAE

UniProt

F4LRZ6 - F4LRZ6_TEPAE

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Protein
Glycerol kinase
Gene
glpK, TepiRe1_2381, TepRe1_2213
Organism
Tepidanaerobacter acetatoxydans (strain DSM 21804 / JCM 16047 / Re1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate By similarity.UniRule annotation

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotationSAAS annotations

Enzyme regulationi

Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP) By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111Substrate By similarityUniRule annotation
Binding sitei15 – 151ATP By similarityUniRule annotation
Binding sitei264 – 2641ATP By similarityUniRule annotation
Binding sitei306 – 3061ATP; via carbonyl oxygen By similarityUniRule annotation
Binding sitei310 – 3101ATP; via amide nitrogen By similarityUniRule annotation
Binding sitei325 – 3251ATP By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 133ATP By similarityUniRule annotation
Nucleotide bindingi407 – 4115ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glycerol kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycerol catabolic process Source: UniProtKB-UniPathway
  2. glycerol-3-phosphate metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

Glycerol metabolismUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciTSP499229:GHS2-2265-MONOMER.
UniPathwayiUPA00618; UER00672.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinaseUniRule annotation (EC:2.7.1.30UniRule annotation)
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Gene namesi
Name:glpKUniRule annotationImported
Ordered Locus Names:TepiRe1_2381Imported, TepRe1_2213Imported
OrganismiTepidanaerobacter acetatoxydans (strain DSM 21804 / JCM 16047 / Re1)
Taxonomic identifieri1209989 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeTepidanaerobacter
ProteomesiUP000008463: Chromosome

Interactioni

Subunit structurei

Homotetramer and homodimer (in equilibrium) By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF4LRZ6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni81 – 822Substrate binding By similarityUniRule annotation
Regioni242 – 2432Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00864.

Family and domain databases

HAMAPiMF_00186. Glycerol_kin.
InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F4LRZ6-1 [UniParc]FASTAAdd to Basket

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MGRILVIDQG TTGSRAIIFD EHGERLFMEY KEFRQIYPKP GWVEHDPMEI    50
WDVTLDVTKR VLANANMSGK DISAIGITNQ RETTTLWDKN TGKPLYNSIV 100
WACRRTTDIC QDLISKGYNE IFNKKTGLII DPVYSATKIR WIMDNVDGVK 150
EKVDRDEVLF GTIDSWLLWN LTGGNVHATD FSNASRTMLF NVKDIKWDEE 200
LLKIMDIPAN MLPEVKPSVG LFGYTDKKLF GKEIPITGIA GDQQAALFGQ 250
TCFEEGDTKN TYGTSCVPLM FTGTKPVFTD KGLLTLAWGY NNEVKYSMGA 300
SIFTAGSAIQ WLRDNLNLIS SSSETEELAK SVEDNAGVYF VPAFTGLGAP 350
HWDMYARGMI IGLTSNATKA HLVRATLESL AYQTRDLLDE IESKSAIKLK 400
CLKVDGGAAK NNFLMQFQAD ILNCPVIRPK DIETTSLGAA YMAGLGIGIW 450
KDENEIKQLW KIDKEFYPSM QKDKREELYS NWKHAVEHAR GWLKK 495
Length:495
Mass (Da):55,718
Last modified:June 28, 2011 - v1
Checksum:i724C5367C8850590
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002728 Genomic DNA. Translation: AEE92335.1.
HF563609 Genomic DNA. Translation: CDI40973.1.
RefSeqiWP_013779254.1. NC_019954.2.
YP_004461642.1. NC_015519.1.
YP_008619215.1. NC_019954.2.

Genome annotation databases

EnsemblBacteriaiAEE92335; AEE92335; TepRe1_2213.
GeneIDi10599002.
17374057.
KEGGitae:TepiRe1_2381.
tep:TepRe1_2213.
PATRICi54627585. VBITepSp18581_2319.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002728 Genomic DNA. Translation: AEE92335.1 .
HF563609 Genomic DNA. Translation: CDI40973.1 .
RefSeqi WP_013779254.1. NC_019954.2.
YP_004461642.1. NC_015519.1.
YP_008619215.1. NC_019954.2.

3D structure databases

ProteinModelPortali F4LRZ6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEE92335 ; AEE92335 ; TepRe1_2213 .
GeneIDi 10599002.
17374057.
KEGGi tae:TepiRe1_2381.
tep:TepRe1_2213.
PATRICi 54627585. VBITepSp18581_2319.

Phylogenomic databases

KOi K00864.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00672 .
BioCyci TSP499229:GHS2-2265-MONOMER.

Family and domain databases

HAMAPi MF_00186. Glycerol_kin.
InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01311. glycerol_kin. 1 hit.
PROSITEi PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of Tepidanaerobacter sp. Re1."
    US DOE Joint Genome Institute
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Pagani I., Teshima H., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Lcollab F.I., Woyke T.
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 21804 / JCM 16047 / Re1 and Re1Imported.
  2. "First Genome Sequence of a Syntrophic Acetate-Oxidizing Bacterium, Tepidanaerobacter acetatoxydans Strain Re1."
    Manzoor S., Bongcam-Rudloff E., Schnurer A., Muller B.
    Genome Announc. 1:e00213-e00212(2013)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Re1Imported.
  3. "First genome sequence of a syntrophic acetate-oxidizing bacterium, Tepidanaerobacter acetatoxydans strain Re1."
    Manzoor S., Bongcam-Rudloff E., Schnurer A., Muller B.
    Genome Announc. 1:E00213-E00213(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiF4LRZ6_TEPAE
AccessioniPrimary (citable) accession number: F4LRZ6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 3, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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