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F4LRZ6

- F4LRZ6_TEPAE

UniProt

F4LRZ6 - F4LRZ6_TEPAE

Protein

Glycerol kinase

Gene

glpK

Organism
Tepidanaerobacter acetatoxydans (strain DSM 21804 / JCM 16047 / Re1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.UniRule annotation

    Catalytic activityi

    ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotationSAAS annotation

    Enzyme regulationi

    Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111SubstrateUniRule annotation
    Binding sitei15 – 151ATPUniRule annotation
    Binding sitei264 – 2641ATPUniRule annotation
    Binding sitei306 – 3061ATP; via carbonyl oxygenUniRule annotation
    Binding sitei310 – 3101ATP; via amide nitrogenUniRule annotation
    Binding sitei325 – 3251ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 133ATPUniRule annotation
    Nucleotide bindingi407 – 4115ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glycerol kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycerol-3-phosphate metabolic process Source: UniProtKB-HAMAP
    2. glycerol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    Glycerol metabolismUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTSP499229:GHS2-2265-MONOMER.
    UniPathwayiUPA00618; UER00672.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol kinaseUniRule annotation (EC:2.7.1.30UniRule annotation)
    Alternative name(s):
    ATP:glycerol 3-phosphotransferaseUniRule annotation
    GlycerokinaseUniRule annotation
    Gene namesi
    Name:glpKUniRule annotationImported
    Ordered Locus Names:TepiRe1_2381Imported, TepRe1_2213Imported
    OrganismiTepidanaerobacter acetatoxydans (strain DSM 21804 / JCM 16047 / Re1)Imported
    Taxonomic identifieri1209989 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeTepidanaerobacter
    ProteomesiUP000010802: Chromosome

    Interactioni

    Subunit structurei

    Homotetramer and homodimer (in equilibrium).UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliF4LRZ6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni81 – 822Substrate bindingUniRule annotation
    Regioni242 – 2432Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the FGGY kinase family.UniRule annotation

    Phylogenomic databases

    KOiK00864.

    Family and domain databases

    HAMAPiMF_00186. Glycerol_kin.
    InterProiIPR018485. Carb_kinase_FGGY_C.
    IPR018483. Carb_kinase_FGGY_CS.
    IPR018484. Carb_kinase_FGGY_N.
    IPR005999. Glycerol_kin.
    [Graphical view]
    PfamiPF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
    PROSITEiPS00445. FGGY_KINASES_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F4LRZ6-1 [UniParc]FASTAAdd to Basket

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    MGRILVIDQG TTGSRAIIFD EHGERLFMEY KEFRQIYPKP GWVEHDPMEI    50
    WDVTLDVTKR VLANANMSGK DISAIGITNQ RETTTLWDKN TGKPLYNSIV 100
    WACRRTTDIC QDLISKGYNE IFNKKTGLII DPVYSATKIR WIMDNVDGVK 150
    EKVDRDEVLF GTIDSWLLWN LTGGNVHATD FSNASRTMLF NVKDIKWDEE 200
    LLKIMDIPAN MLPEVKPSVG LFGYTDKKLF GKEIPITGIA GDQQAALFGQ 250
    TCFEEGDTKN TYGTSCVPLM FTGTKPVFTD KGLLTLAWGY NNEVKYSMGA 300
    SIFTAGSAIQ WLRDNLNLIS SSSETEELAK SVEDNAGVYF VPAFTGLGAP 350
    HWDMYARGMI IGLTSNATKA HLVRATLESL AYQTRDLLDE IESKSAIKLK 400
    CLKVDGGAAK NNFLMQFQAD ILNCPVIRPK DIETTSLGAA YMAGLGIGIW 450
    KDENEIKQLW KIDKEFYPSM QKDKREELYS NWKHAVEHAR GWLKK 495
    Length:495
    Mass (Da):55,718
    Last modified:June 28, 2011 - v1
    Checksum:i724C5367C8850590
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002728 Genomic DNA. Translation: AEE92335.1.
    HF563609 Genomic DNA. Translation: CDI40973.1.
    RefSeqiWP_013779254.1. NC_019954.2.
    YP_004461642.1. NC_015519.1.
    YP_008619215.1. NC_019954.2.

    Genome annotation databases

    EnsemblBacteriaiAEE92335; AEE92335; TepRe1_2213.
    GeneIDi10599002.
    17374057.
    KEGGitae:TepiRe1_2381.
    tep:TepRe1_2213.
    PATRICi54627585. VBITepSp18581_2319.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002728 Genomic DNA. Translation: AEE92335.1 .
    HF563609 Genomic DNA. Translation: CDI40973.1 .
    RefSeqi WP_013779254.1. NC_019954.2.
    YP_004461642.1. NC_015519.1.
    YP_008619215.1. NC_019954.2.

    3D structure databases

    ProteinModelPortali F4LRZ6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEE92335 ; AEE92335 ; TepRe1_2213 .
    GeneIDi 10599002.
    17374057.
    KEGGi tae:TepiRe1_2381.
    tep:TepRe1_2213.
    PATRICi 54627585. VBITepSp18581_2319.

    Phylogenomic databases

    KOi K00864.

    Enzyme and pathway databases

    UniPathwayi UPA00618 ; UER00672 .
    BioCyci TSP499229:GHS2-2265-MONOMER.

    Family and domain databases

    HAMAPi MF_00186. Glycerol_kin.
    InterProi IPR018485. Carb_kinase_FGGY_C.
    IPR018483. Carb_kinase_FGGY_CS.
    IPR018484. Carb_kinase_FGGY_N.
    IPR005999. Glycerol_kin.
    [Graphical view ]
    Pfami PF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01311. glycerol_kin. 1 hit.
    PROSITEi PS00445. FGGY_KINASES_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Tepidanaerobacter sp. Re1."
      US DOE Joint Genome Institute
      Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Pagani I., Teshima H., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Lcollab F.I., Woyke T.
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Re1Imported.
    2. "First Genome Sequence of a Syntrophic Acetate-Oxidizing Bacterium, Tepidanaerobacter acetatoxydans Strain Re1."
      Manzoor S., Bongcam-Rudloff E., Schnurer A., Muller B.
      Genome Announc. 1:e00213-e00212(2013)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Re1Imported.
    3. "First genome sequence of a syntrophic acetate-oxidizing bacterium, Tepidanaerobacter acetatoxydans strain Re1."
      Manzoor S., Bongcam-Rudloff E., Schnurer A., Muller B.
      Genome Announc. 1:E00213-E00213(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiF4LRZ6_TEPAE
    AccessioniPrimary (citable) accession number: F4LRZ6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3