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F4LRX7

- F4LRX7_TEPAE

UniProt

F4LRX7 - F4LRX7_TEPAE

Protein

Thymidine kinase

Gene

tdk

Organism
Tepidanaerobacter acetatoxydans (strain DSM 21804 / JCM 16047 / Re1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei90 – 901Proton acceptorUniRule annotation
    Metal bindingi146 – 1461ZincUniRule annotation
    Metal bindingi149 – 1491ZincUniRule annotation
    Metal bindingi178 – 1781ZincUniRule annotation
    Metal bindingi181 – 1811ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 228ATPUniRule annotation
    Nucleotide bindingi89 – 924ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

    Enzyme and pathway databases

    BioCyciTSP499229:GHS2-2246-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotationImported
    Ordered Locus Names:TepiRe1_2362Imported, TepRe1_2194Imported
    OrganismiTepidanaerobacter acetatoxydans (strain DSM 21804 / JCM 16047 / Re1)Imported
    Taxonomic identifieri1209989 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeTepidanaerobacter
    ProteomesiUP000010802: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    KOiK00857.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F4LRX7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIRPDFGWIE VIASGAMYAG KTREFIKRID ELKWAKKKIL IVKPMLDDRY    50
    GESCVMSHNG DNVTAINIKC PLEILELIKR DNYDVVAIDE AQFFDKKIVQ 100
    VIKDLRDSGF LVLITGLNTT AEGKPFGPMP EILCIADDIT ILYGVCAACG 150
    KPATKTLALF DKDQDIVVGG QGKYEPRCNK HWVHNRL 187
    Length:187
    Mass (Da):21,016
    Last modified:June 28, 2011 - v1
    Checksum:iB96D28804D913AB0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002728 Genomic DNA. Translation: AEE92316.1.
    HF563609 Genomic DNA. Translation: CCP27200.2.
    RefSeqiWP_013779235.1. NC_019954.2.
    YP_004461623.1. NC_015519.1.
    YP_007273176.2. NC_019954.2.

    Genome annotation databases

    EnsemblBacteriaiAEE92316; AEE92316; TepRe1_2194.
    CCP27200; CCP27200; TepiRe1_2362.
    GeneIDi10598983.
    14424187.
    KEGGitae:TepiRe1_2362.
    tep:TepRe1_2194.
    PATRICi54627547. VBITepSp18581_2300.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002728 Genomic DNA. Translation: AEE92316.1 .
    HF563609 Genomic DNA. Translation: CCP27200.2 .
    RefSeqi WP_013779235.1. NC_019954.2.
    YP_004461623.1. NC_015519.1.
    YP_007273176.2. NC_019954.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEE92316 ; AEE92316 ; TepRe1_2194 .
    CCP27200 ; CCP27200 ; TepiRe1_2362 .
    GeneIDi 10598983.
    14424187.
    KEGGi tae:TepiRe1_2362.
    tep:TepRe1_2194.
    PATRICi 54627547. VBITepSp18581_2300.

    Phylogenomic databases

    KOi K00857.

    Enzyme and pathway databases

    BioCyci TSP499229:GHS2-2246-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Tepidanaerobacter sp. Re1."
      US DOE Joint Genome Institute
      Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Pagani I., Teshima H., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Lcollab F.I., Woyke T.
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Re1Imported.
    2. "First Genome Sequence of a Syntrophic Acetate-Oxidizing Bacterium, Tepidanaerobacter acetatoxydans Strain Re1."
      Manzoor S., Bongcam-Rudloff E., Schnurer A., Muller B.
      Genome Announc. 1:e00213-e00212(2013)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Re1Imported.
    3. "First genome sequence of a syntrophic acetate-oxidizing bacterium, Tepidanaerobacter acetatoxydans strain Re1."
      Manzoor S., Bongcam-Rudloff E., Schnurer A., Muller B.
      Genome Announc. 1:E00213-E00213(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiF4LRX7_TEPAE
    AccessioniPrimary (citable) accession number: F4LRX7
    Secondary accession number(s): L0S1S1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3