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F4LRX7

- F4LRX7_TEPAE

UniProt

F4LRX7 - F4LRX7_TEPAE

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Protein
Thymidine kinase
Gene
tdk, TepiRe1_2362, TepRe1_2194
Organism
Tepidanaerobacter acetatoxydans (strain DSM 21804 / JCM 16047 / Re1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei90 – 901Proton acceptor By similarityUniRule annotation
Metal bindingi146 – 1461Zinc By similarityUniRule annotation
Metal bindingi149 – 1491Zinc By similarityUniRule annotation
Metal bindingi178 – 1781Zinc By similarityUniRule annotation
Metal bindingi181 – 1811Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228ATP By similarityUniRule annotation
Nucleotide bindingi89 – 924ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciTSP499229:GHS2-2246-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:TepiRe1_2362Imported, TepRe1_2194Imported
OrganismiTepidanaerobacter acetatoxydans (strain DSM 21804 / JCM 16047 / Re1)
Taxonomic identifieri1209989 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeTepidanaerobacter
ProteomesiUP000008463: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

F4LRX7-1 [UniParc]FASTAAdd to Basket

« Hide

MIRPDFGWIE VIASGAMYAG KTREFIKRID ELKWAKKKIL IVKPMLDDRY    50
GESCVMSHNG DNVTAINIKC PLEILELIKR DNYDVVAIDE AQFFDKKIVQ 100
VIKDLRDSGF LVLITGLNTT AEGKPFGPMP EILCIADDIT ILYGVCAACG 150
KPATKTLALF DKDQDIVVGG QGKYEPRCNK HWVHNRL 187
Length:187
Mass (Da):21,016
Last modified:June 28, 2011 - v1
Checksum:iB96D28804D913AB0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002728 Genomic DNA. Translation: AEE92316.1.
HF563609 Genomic DNA. Translation: CCP27200.2.
RefSeqiWP_013779235.1. NC_019954.2.
YP_004461623.1. NC_015519.1.
YP_007273176.2. NC_019954.2.

Genome annotation databases

EnsemblBacteriaiAEE92316; AEE92316; TepRe1_2194.
CCP27200; CCP27200; TepiRe1_2362.
GeneIDi10598983.
14424187.
KEGGitae:TepiRe1_2362.
tep:TepRe1_2194.
PATRICi54627547. VBITepSp18581_2300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002728 Genomic DNA. Translation: AEE92316.1 .
HF563609 Genomic DNA. Translation: CCP27200.2 .
RefSeqi WP_013779235.1. NC_019954.2.
YP_004461623.1. NC_015519.1.
YP_007273176.2. NC_019954.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEE92316 ; AEE92316 ; TepRe1_2194 .
CCP27200 ; CCP27200 ; TepiRe1_2362 .
GeneIDi 10598983.
14424187.
KEGGi tae:TepiRe1_2362.
tep:TepRe1_2194.
PATRICi 54627547. VBITepSp18581_2300.

Phylogenomic databases

KOi K00857.

Enzyme and pathway databases

BioCyci TSP499229:GHS2-2246-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of Tepidanaerobacter sp. Re1."
    US DOE Joint Genome Institute
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Pagani I., Teshima H., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Lcollab F.I., Woyke T.
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 21804 / JCM 16047 / Re1 and Re1Imported.
  2. "First Genome Sequence of a Syntrophic Acetate-Oxidizing Bacterium, Tepidanaerobacter acetatoxydans Strain Re1."
    Manzoor S., Bongcam-Rudloff E., Schnurer A., Muller B.
    Genome Announc. 1:e00213-e00212(2013)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Re1Imported.
  3. "First genome sequence of a syntrophic acetate-oxidizing bacterium, Tepidanaerobacter acetatoxydans strain Re1."
    Manzoor S., Bongcam-Rudloff E., Schnurer A., Muller B.
    Genome Announc. 1:E00213-E00213(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiF4LRX7_TEPAE
AccessioniPrimary (citable) accession number: F4LRX7
Secondary accession number(s): L0S1S1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 3, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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