D-alanine--D-alanine ligase - Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O)

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F4L0Y0 (F4L0Y0_HALH1) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 18. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Recommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047
EC=6.3.2.4 HAMAP-Rule MF_00047

Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047

Gene names

Name:	ddl HAMAP-Rule MF_00047
Ordered Locus Names:	Halhy_2716 EMBL AEE50584.1

Organism

Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O) [Complete proteome] [HAMAP] EMBL AEE50584.1

Taxonomic identifier

760192 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Sphingobacteriia › Sphingobacteriales › Saprospiraceae › Haliscomenobacter ›

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS000291
Catalytic activity	ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS000291
Cofactor	Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS000291
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS000291
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS000291.
Sequence similarities	Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047 Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047 SAAS SAAS000291

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation HAMAP-Rule MF_00047 SAAS SAAS000291 Peptidoglycan synthesis HAMAP-Rule MF_00047 SAAS SAAS000291
Cellular component	Cytoplasm HAMAP-Rule MF_00047 SAAS SAAS000291
Ligand	ATP-binding HAMAP-Rule MF_00047 SAAS SAAS000291 Magnesium HAMAP-Rule MF_00047 SAAS SAAS000291 Manganese HAMAP-Rule MF_00047 SAAS SAAS000291 Metal-binding HAMAP-Rule MF_00047 SAAS SAAS000291 Nucleotide-binding
Molecular function	Ligase HAMAP-Rule MF_00047 SAAS SAAS000291 EMBL AEE50584.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP D-alanine-D-alanine ligase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Regions

Domain

117 – 315

199

ATP-grasp By similarity HAMAP-Rule MF_00047

Nucleotide binding

144 – 199

ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding

270

Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047

Metal binding

282

Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047

Metal binding

282

Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Metal binding

284

Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence

Length

Mass (Da)

Tools

F4L0Y0 [UniParc].

Last modified June 28, 2011. Version 1.
Checksum: 50844D13A7CBA7CF
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FASTA

329

36,287

        10         20         30         40         50         60 
MLKVAILTGG NVAERSVSLK SAETVRKHLN DQKYEKYVIE LNGTQFTEQG TGTVVNLNDF 

        70         80         90        100        110        120 
SLPTPNGNIK FDLVYQMLHG HPAEDGCLQG YFEVLGIPYT GCDVMSSAIT FNKQACKDFL 

       130        140        150        160        170        180 
RSHNIPMAPS KVLRKGEAIN WAELEAMGVP VFVKPNKNGS SYGASKVNTP DQLAGAIEHA 

       190        200        210        220        230        240 
FVYDDEVVVE GFLKGTEFSN GVLRRNGEVV VLPITEIVPH NEFFDFKAKY ENQSQEITPA 

       250        260        270        280        290        300 
RLTPEQTAQV QAQTKLIYEA VGCRGICRFD YILVGDTFFF LEANTIPGMS EQSIVPQQAR 

       310        320 
AHGWSITELL DAAVDEALER QAMKLSVGN

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Haliscomenobacter hydrossis type strain (O)." US DOE Joint Genome Institute (JGI-PGF) Daligault H., Lapidus A., Zeytun A., Nolan M., Lucas S., Del Rio T.G., Tice H., Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S., Liolios K., Pagani I., Ivanova N., Huntemann M., Mavromatis K., Mikhailova N. Woyke T. Stand. Genomic Sci. 4:352-360(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27775 / DSM 1100 / LMG 10767 / O.
[2]	"Complete sequence of chromosome of Haliscomenobacter hydrossis DSM 1100." US DOE Joint Genome Institute (JGI-PGF) Lucas S., Han J., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L., Kyrpides N., Mavromatis K., Ivanova N., Ovchinnikova G., Pagani I., Daligault H., Detter J.C., Han C., Land M., Hauser L., Markowitz V. Eisen J.A. Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: DSM 1100.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002691 Genomic DNA. Translation: AEE50584.1.
RefSeq	YP_004447457.1. NC_015510.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AEE50584; AEE50584; Halhy_2716.
GeneID	10586888.
KEGG	hhy:Halhy_2716.
PATRIC	54602154. VBIHalHyd147579_2922.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K01921.
Enzyme and pathway databases
BioCyc	HHYD760192:GI21-2738-MONOMER.
UniPathway	UPA00219.
Family and domain databases
Gene3D	3.30.1490.20. 1 hit. 3.30.470.20. 2 hits. 3.40.50.20. 1 hit.
HAMAP	MF_00047. Dala_Dala_lig.
InterPro	IPR011761. ATP-grasp. IPR013815. ATP_grasp_subdomain_1. IPR013816. ATP_grasp_subdomain_2. IPR000291. D-Ala_lig_Van_CS. IPR005905. D_ala_D_ala. IPR011095. Dala_Dala_lig_C. IPR011127. Dala_Dala_lig_N. IPR016185. PreATP-grasp_dom. [Graphical view]
PANTHER	PTHR23132. PTHR23132. 1 hit.
Pfam	PF07478. Dala_Dala_lig_C. 1 hit. PF01820. Dala_Dala_lig_N. 1 hit. [Graphical view]
SUPFAM	SSF52440. PreATP-grasp-like. 1 hit.
TIGRFAMs	TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITE	PS50975. ATP_GRASP. 1 hit. PS00844. DALA_DALA_LIGASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F4L0Y0_HALH1

Accession

Primary (citable) accession number: F4L0Y0

Entry history

Integrated into UniProtKB/TrEMBL:	June 28, 2011
Last sequence update:	June 28, 2011
Last modified:	May 29, 2013
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information