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Protein

L-aspartate oxidase

Gene

Poras_0264

Organism
Porphyromonas asaccharolytica (strain ATCC 25260 / DSM 20707 / VPI 4198) (Bacteroides asaccharolyticus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of L-aspartate to iminoaspartate.UniRule annotation

Catalytic activityi

L-aspartate + O2 = iminosuccinate + H2O2.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes iminoaspartate from L-aspartate (oxidase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-aspartate oxidase (Poras_0264)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes iminoaspartate from L-aspartate (oxidase route), the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein

Enzyme and pathway databases

BioCyciPASA879243:GJ3V-270-MONOMER.
UniPathwayiUPA00253; UER00326.

Names & Taxonomyi

Protein namesi
Recommended name:
L-aspartate oxidaseUniRule annotation (EC:1.4.3.16UniRule annotation)
Gene namesi
Ordered Locus Names:Poras_0264Imported
OrganismiPorphyromonas asaccharolytica (strain ATCC 25260 / DSM 20707 / VPI 4198) (Bacteroides asaccharolyticus)Imported
Taxonomic identifieri879243 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
Proteomesi
  • UP000006545 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 2918HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiF4KM99.

Interactioni

Protein-protein interaction databases

STRINGi879243.Poras_0264.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 383373FAD_binding_2InterPro annotationAdd
BLAST
Domaini439 – 51678Succ_DH_flav_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4108IYU. Bacteria.
COG0029. LUCA.
KOiK00278.
OMAiHCVQWLI.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR005288. NadB.
IPR030664. SdhA/FrdA/AprA.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000171. SDHA_APRA_LASPO. 1 hit.
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 2 hits.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR00551. nadB. 1 hit.

Sequencei

Sequence statusi: Complete.

F4KM99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLQQSPQRY DYIIIGGGLA GLYCAYFLAQ HGSVALIARR TIEESNSYYA
60 70 80 90 100
QGGMAAVTDQ EDSPTDHYED TIVAGRGLCI PEAVKILTDE APERINELIQ
110 120 130 140 150
MGMTFDSEDG HLALGLEGGH HHRRILHAGG DATGRLVTTF MIEQVRKAQH
160 170 180 190 200
ITIFDHHSAV QVLRSADGSH CQGLVTYDER AHHYDTILAS AVVLATGGAA
210 220 230 240 250
ALYYPTTNPP TALGDGLWLA SEVGAELMDL EFIQFHPTAL YLPGYASFLI
260 270 280 290 300
SEAVRGEGAY LVDKHGERFM PALHPLAELA PRDVVARSIF LKMQEEGTDH
310 320 330 340 350
VRLRLRHIDP KRLLQRFPTI SEHCRQLGLD ITDEIPVAPA AHYTVGGIGV
360 370 380 390 400
DLNGCTRLPG LYAVGEVSST GVMGANRLAS NSLIECIVFG KRIADYAIAH
410 420 430 440 450
PITPTDTASL AVPTNLPDLS WSLDKEQIYA LEEQTKISRQ MGDILMSRVG
460 470 480 490 500
IIRSKEGLIE ALHALQHLSD TLAEDAQHSI HAYMTRRRVE VAHMMAHAAL
510 520 530
LREESRGGHY RSDYTETLPE SEAYRTRLLD GEITHQPIN
Length:539
Mass (Da):59,286
Last modified:June 28, 2011 - v1
Checksum:i8AA988284FA5638B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002689 Genomic DNA. Translation: AEE12218.1.
RefSeqiWP_004330468.1. NC_015501.1.

Genome annotation databases

EnsemblBacteriaiAEE12218; AEE12218; Poras_0264.
KEGGipah:Poras_0264.
PATRICi54587617. VBIPorAsa172508_0254.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002689 Genomic DNA. Translation: AEE12218.1.
RefSeqiWP_004330468.1. NC_015501.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi879243.Poras_0264.

Proteomic databases

PRIDEiF4KM99.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEE12218; AEE12218; Poras_0264.
KEGGipah:Poras_0264.
PATRICi54587617. VBIPorAsa172508_0254.

Phylogenomic databases

eggNOGiENOG4108IYU. Bacteria.
COG0029. LUCA.
KOiK00278.
OMAiHCVQWLI.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00326.
BioCyciPASA879243:GJ3V-270-MONOMER.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR005288. NadB.
IPR030664. SdhA/FrdA/AprA.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000171. SDHA_APRA_LASPO. 1 hit.
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 2 hits.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR00551. nadB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25260 / DSM 20707 / VPI 4198Imported.

Entry informationi

Entry nameiF4KM99_PORAD
AccessioniPrimary (citable) accession number: F4KM99
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: June 8, 2016
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.