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Protein

Transmembrane 9 superfamily member 8

Gene

TMN8

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 9 superfamily member 8Curated
Alternative name(s):
Endomembrane protein 11 Publication
Transmembrane nine protein 81 Publication
Short name:
AtTMN81 Publication
Gene namesi
Name:TMN81 Publication
Synonyms:EMP11 Publication
Ordered Locus Names:At5g10840Imported
ORF Names:T30N20_110Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G10840.
TAIRilocus:2183710. AT5G10840.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 285LumenalCuratedAdd BLAST252
Transmembranei286 – 306Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini307 – 355CytoplasmicCuratedAdd BLAST49
Transmembranei356 – 376Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini377 – 381LumenalCurated5
Transmembranei382 – 402Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini403 – 422CytoplasmicCuratedAdd BLAST20
Transmembranei423 – 443Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini444 – 455LumenalCuratedAdd BLAST12
Transmembranei456 – 476Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini477 – 506CytoplasmicCuratedAdd BLAST30
Transmembranei507 – 527Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini528 – 538LumenalCuratedAdd BLAST11
Transmembranei539 – 559Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini560 – 577CytoplasmicCuratedAdd BLAST18
Transmembranei578 – 598Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini599 – 604LumenalCurated6
Transmembranei605 – 625Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini626 – 648CytoplasmicCuratedAdd BLAST23

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000043126534 – 648Transmembrane 9 superfamily member 8Sequence analysisAdd BLAST615

Proteomic databases

PaxDbiF4KIB2.

PTM databases

SwissPalmiF4KIB2.

Expressioni

Gene expression databases

GenevisibleiF4KIB2. AT.

Interactioni

Protein-protein interaction databases

BioGridi16229. 32 interactors.
STRINGi3702.AT5G10840.1.

Structurei

3D structure databases

ProteinModelPortaliF4KIB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi637 – 642Endoplasmic reticulum export signalBy similarity6
Motifi646 – 648Golgi retention signalBy similarity3

Domaini

The C-terminal KXD/E motif functions as a Golgi retention signal, certainly through the binding to the COP1 coatomer.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1278. Eukaryota.
ENOG410XPIW. LUCA.
HOGENOMiHOG000216679.
InParanoidiQ9LEV5.
KOiK17086.
OMAiWDKYLHV.
OrthoDBiEOG093604KV.

Family and domain databases

InterProiView protein in InterPro
IPR004240. EMP70.
IPR036259. MFS_trans_sf.
PANTHERiPTHR10766. PTHR10766. 1 hit.
PfamiView protein in Pfam
PF02990. EMP70. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

F4KIB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMEFLRSSR RILESSGCAI ALIFLLFIHG AHSFYLPGVA PQDFEKGDEL
60 70 80 90 100
KVKVNKLTSI KTQLPYSYYS LPFCRPSKIV DSTENLGEVL RGDRIENAPY
110 120 130 140 150
SFKMREAQMC NILGRVTLDA KTAKAFKEKI DDEYRVNMIL DNLPLVVPIE
160 170 180 190 200
RVDQGSPSVV YQLGYHVGLK GQYEGSKEQK FFMHNHLAFT VRYHRDIQTD
210 220 230 240 250
AARIVGFEVK PYSVKHEYEG EWSEKTRLTT CDPHTKRLVV SSATPQEVEQ
260 270 280 290 300
KKEIIFTYDV DFQESEVKWA SRWDTYLLMS DNQIHWFSIV NSLMIVLFLS
310 320 330 340 350
GMVAMIMLRT LYRDISRYNE LETQEEAQEE TGWKLVHGDV FRLPTNSDLL
360 370 380 390 400
CVYVGTGVQC LGMVFVTMIF AMLGFLSPSN RGGLMTAMLL LWVFMGLFAG
410 420 430 440 450
YASSRLYKMF KGTEWKRIAF RTAFLFPAVV SAIFFVLNAL IWGQKSSGAV
460 470 480 490 500
PFGTMFALIF LWFGISVPLV FVGGYIGFKK PAADDPVKTN KIPRQIPEQA
510 520 530 540 550
WYMNPVFSIL IGGILPFGAV FIELFFILTS IWLNQFYYIF GFLFLVFVIL
560 570 580 590 600
IVTCAEITVV LCYFQLCSED YLWWWRSYLT SGSSALYLFL YATFYFFTKL
610 620 630 640
QITKLVSAML YFGYMLIASY AFFVLTGTIG FYACLWFTRL IYSSVKID
Length:648
Mass (Da):74,467
Last modified:June 28, 2011 - v1
Checksum:iA2E22FC979A8360E
GO

Sequence cautioni

The sequence BX833631 differs from that shown. Reason: Frameshift at positions 554 and 575.Curated
The sequence CAB96839 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti570D → E in BX833631 (PubMed:14993207).1
Sequence conflicti592A → T in BX833631 (PubMed:14993207).1
Sequence conflicti612F → L in BX833631 (PubMed:14993207).1
Sequence conflicti623F → I in BX833631 (PubMed:14993207).1
Sequence conflicti634C → Y in BX833631 (PubMed:14993207).1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365234 Genomic DNA. Translation: CAB96839.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED91602.1.
BX833631 mRNA. No translation available.
PIRiT50793.
RefSeqiNP_196645.2. NM_121122.4.
UniGeneiAt.27558.
At.49006.

Genome annotation databases

EnsemblPlantsiAT5G10840.1; AT5G10840.1; AT5G10840.
GeneIDi830951.
GrameneiAT5G10840.1; AT5G10840.1; AT5G10840.
KEGGiath:AT5G10840.

Similar proteinsi

Entry informationi

Entry nameiTMN8_ARATH
AccessioniPrimary (citable) accession number: F4KIB2
Secondary accession number(s): Q9LEV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 26, 2014
Last sequence update: June 28, 2011
Last modified: October 25, 2017
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families