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Protein

Disease resistance protein RPP2B

Gene

RPP2B

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Disease resistance protein that cooperates with RPP2A to confer resistance to Hyaloperonospora parasitica isolate Cala2.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processPlant defense
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Disease resistance protein RPP2BCurated
Gene namesi
Name:RPP2B1 Publication
Ordered Locus Names:At4g19510Imported
ORF Names:F24J7.70Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G19510
TAIRilocus:2122965 AT4G19510

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi121G → E: Enhanced susceptibility to Hyaloperonospora parasitica. 1 Publication1
Mutagenesisi726L → F: Enhanced susceptibility to Hyaloperonospora parasitica. 1 Publication1
Mutagenesisi944T → M: Enhanced susceptibility to Hyaloperonospora parasitica. 1 Publication1
Mutagenesisi955E → K: Enhanced susceptibility to Hyaloperonospora parasitica. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004445571 – 1207Disease resistance protein RPP2BAdd BLAST1207

Proteomic databases

ProMEXiO49469

Expressioni

Gene expression databases

ExpressionAtlasiO49469 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G19510.1

Structurei

3D structure databases

ProteinModelPortaliF4JT80
SMRiF4JT80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 154TIRPROSITE-ProRule annotationAdd BLAST140
Domaini201 – 445NB-ARCSequence analysisAdd BLAST245
Repeati607 – 630LRR 1Sequence analysisAdd BLAST24
Repeati653 – 676LRR 2Sequence analysisAdd BLAST24
Repeati677 – 699LRR 3Sequence analysisAdd BLAST23
Repeati720 – 743LRR 4Sequence analysisAdd BLAST24
Repeati744 – 767LRR 5Sequence analysisAdd BLAST24
Repeati769 – 791LRR 6Sequence analysisAdd BLAST23
Repeati792 – 815LRR 7Sequence analysisAdd BLAST24
Repeati840 – 862LRR 8Sequence analysisAdd BLAST23
Repeati863 – 886LRR 9Sequence analysisAdd BLAST24

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410J8UW Eukaryota
ENOG4112BMQ LUCA
HOGENOMiHOG000064702
InParanoidiF4JT80
OMAiSEDYANS
OrthoDBiEOG0936121T

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR011713 Leu-rich_rpt_3
IPR032675 LRR_dom_sf
IPR002182 NB-ARC
IPR027417 P-loop_NTPase
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PfamiView protein in Pfam
PF07725 LRR_3, 1 hit
PF13855 LRR_8, 1 hit
PF00931 NB-ARC, 1 hit
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00255 TIR, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 5 hits
PS50104 TIR, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: F4JT80-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFASSSSSI VLSKCEFDVF VSFRGADTRH DFTSHLVKYL RGKGIDVFSD
60 70 80 90 100
AKLRGGEYIS LLFDRIEQSK MSIVVFSEDY ANSWWCLEEV GKIMQRRKEF
110 120 130 140 150
NHGVLPIFYK VSKSDVSNQT GSFEAVFQSP TKIFNGDEQK IEELKVALKT
160 170 180 190 200
ASNIRGFVYP ENSSEPDFLD EIVKNTFRML NELSPCVIPD DLPGIESRSK
210 220 230 240 250
ELEKLLMFDN DECVRVVGVL GMTGIGKTTV ADIVYKQNFQ RFDGYEFLED
260 270 280 290 300
IEDNSKRYGL PYLYQKLLHK LLDGENVDVR AQGRPENFLR NKKLFIVLDN
310 320 330 340 350
VTEEKQIEYL IGKKNVYRQG SRIVIITRDK KLLQKNADAT YVVPRLNDRE
360 370 380 390 400
AMELFCLQVF GNHYPTEEFV DLSNDFVCYA KGLPLALKLL GKGLLTHDIN
410 420 430 440 450
YWKKKLEFLQ VNPDKELQKE LKSSYKALDD DQKSVFLDIA CFFRSEKADF
460 470 480 490 500
VSSILKSDDI DAKDVMRELE EKCLVTISYD RIEMHDLLHA MGKEIGKEKS
510 520 530 540 550
IRKAGERRRL WNHKDIRDIL EHNTGTECVR GIFLNMSEVR RIKLFPAAFT
560 570 580 590 600
MLSKLKFLKF HSSHCSQWCD NDHIFQCSKV PDHFPDELVY LHWQGYPYDC
610 620 630 640 650
LPSDFDPKEL VDLSLRYSHI KQLWEDEKNT ESLRWVDLGQ SKDLLNLSGL
660 670 680 690 700
SRAKNLERLD LEGCTSLDLL GSVKQMNELI YLNLRDCTSL ESLPKGFKIK
710 720 730 740 750
SLKTLILSGC LKLKDFHIIS ESIESLHLEG TAIERVVEHI ESLHSLILLN
760 770 780 790 800
LKNCEKLKYL PNDLYKLKSL QELVLSGCSA LESLPPIKEK MECLEILLMD
810 820 830 840 850
GTSIKQTPEM SCLSNLKICS FCRPVIDDST GLVVLPFSGN SFLSDLYLTN
860 870 880 890 900
CNIDKLPDKF SSLRSLRCLC LSRNNIETLP ESIEKLYSLL LLDLKHCCRL
910 920 930 940 950
KSLPLLPSNL QYLDAHGCGS LENVSKPLTI PLVTERMHTT FIFTDCFKLN
960 970 980 990 1000
QAEKEDIVAQ AQLKSQLLAR TSRHHNHKGL LLDPLVAVCF PGHDIPSWFS
1010 1020 1030 1040 1050
HQKMGSLIET DLLPHWCNSK FIGASLCVVV TFKDHEGHHA NRLSVRCKSK
1060 1070 1080 1090 1100
FKSQNGQFIS FSFCLGGWNE SCGSSCHEPR KLGSDHVFIS YNNCNVPVFK
1110 1120 1130 1140 1150
WSEETNEGNR CHPTSASFEF YLTDETERKL ECCEILRCGM NFLYARDEND
1160 1170 1180 1190 1200
RKFQGIRVTD TVERTSSEAL VTIRGQSHSR IEERRYGRIR DEIMDMTGSS

MIGGPES
Length:1,207
Mass (Da):138,314
Last modified:June 20, 2018 - v2
Checksum:i55A630F0DAB9CC58
GO
Isoform 2 (identifier: F4JT80-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     445-481: Missing.

Show »
Length:1,170
Mass (Da):134,082
Checksum:i91F44323D6E82397
GO

Sequence cautioni

The sequence AEE84192 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AK229040 differs from that shown. Reason: Erroneous termination at position 387. Translated as Leu.Curated
The sequence ANM66560 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence ANM66561 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence ANM66562 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence ANM66563 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA16928 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB78953 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_059609445 – 481Missing in isoform 2. Add BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021768 Genomic DNA Translation: CAA16928.1 Sequence problems.
AL161551 Genomic DNA Translation: CAB78953.1 Sequence problems.
CP002687 Genomic DNA Translation: ANM66561.1 Different initiation.
CP002687 Genomic DNA Translation: ANM66562.1 Different initiation.
CP002687 Genomic DNA Translation: ANM66563.1 Different initiation.
CP002687 Genomic DNA Translation: AEE84192.1 Different initiation.
CP002687 Genomic DNA Translation: ANM66560.1 Different initiation.
AK229040 mRNA No translation available.
PIRiT06144
RefSeqiNP_001328446.1, NM_001341350.1
NP_193686.5, NM_118071.6
UniGeneiAt.43454

Genome annotation databases

EnsemblPlantsiAT4G19510.1; AT4G19510.1; AT4G19510
AT4G19510.8; AT4G19510.8; AT4G19510
GeneIDi827692
GrameneiAT4G19510.1; AT4G19510.1; AT4G19510
AT4G19510.8; AT4G19510.8; AT4G19510

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRPP2B_ARATH
AccessioniPrimary (citable) accession number: F4JT80
Secondary accession number(s): A0A1P8B4Q1, O49469
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2018
Last sequence update: June 20, 2018
Last modified: June 20, 2018
This is version 62 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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