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Protein

Replication protein A 70 kDa DNA-binding subunit E

Gene

RPA1E

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi241 – 327OBAdd BLAST87
Zinc fingeri532 – 558C4-typeSequence analysisAdd BLAST27

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA recombination, DNA repair, DNA replication
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Replication protein A 70 kDa DNA-binding subunit E
Short name:
AtRPA70E
Alternative name(s):
AtRPA1-1
Replication factor A protein 1E
Replication protein A 1E
Short name:
AtRPA1E
Gene namesi
Name:RPA1E
Synonyms:RPA70E
Ordered Locus Names:At4g19130
ORF Names:T18B16.100
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G19130
TAIRilocus:2134766 AT4G19130

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004226191 – 784Replication protein A 70 kDa DNA-binding subunit EAdd BLAST784

Proteomic databases

PaxDbiF4JSG3
PRIDEiF4JSG3

Expressioni

Gene expression databases

ExpressionAtlasiF4JSG3 baseline and differential
GenevisibleiF4JSG3 AT

Interactioni

Subunit structurei

Heterotrimer of RPA1, RPA2 and RPA3 (canonical replication protein A complex).By similarity

Protein-protein interaction databases

STRINGi3702.AT4G19130.1

Structurei

3D structure databases

ProteinModelPortaliF4JSG3
SMRiF4JSG3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri532 – 558C4-typeSequence analysisAdd BLAST27

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0851 Eukaryota
COG1599 LUCA
InParanoidiF4JSG3
KOiK07466
OMAiPQVGQQR
OrthoDBiEOG093601YN

Family and domain databases

CDDicd04476 RPA1_DBD_C, 1 hit
cd04477 RPA1N, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR004365 NA-bd_OB_tRNA
IPR013955 Rep_factor-A_C
IPR007199 Rep_factor-A_N
IPR031657 REPA_OB_2
IPR004591 Rfa1
IPR001878 Znf_CCHC
PfamiView protein in Pfam
PF04057 Rep-A_N, 1 hit
PF08646 Rep_fac-A_C, 1 hit
PF16900 REPA_OB_2, 1 hit
PF01336 tRNA_anti-codon, 1 hit
SUPFAMiSSF50249 SSF50249, 4 hits
TIGRFAMsiTIGR00617 rpa1, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 1 hit

Sequencei

Sequence statusi: Complete.

F4JSG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVSLTAGAI GKIMNGEVTT EADMIPVLQV TDLKQIMAQQ DPTRERFRMV
60 70 80 90 100
LSDGTYLHQG MLGTDLNNLV KEGTLQPGSI VRLTRFVGDV IKGRRIVIVP
110 120 130 140 150
QLEVLKQISD IIGHPVPGGK HNDQRGADSG IKFNTTEQQG SGIRQVNNIE
160 170 180 190 200
PGRSNAAISP QVGGTGSSVP ASTTPSTRAY SNPSSGNGVT RQDYARDPPT
210 220 230 240 250
SYPHQPQPPP PMYANRGPVA RNEAPPKIIP VNALSPYSGR WTIKARVTNK
260 270 280 290 300
AALKQYSNPR GEGKVFNFDL LDADGGEIRV TCFNAVADQF YDQIVVGNLY
310 320 330 340 350
LISRGSLRPA QKNFNHLRND YEIMLDNAST IKQCYEEDAA IPRHQFHFRT
360 370 380 390 400
IGDIESMENN CIVDVIGIVS SISPTVTITR KNGTATPKRS LQLKDMSGRS
410 420 430 440 450
VEVTMWGDFC NAEGQRLQSL CDSGVFPVLA VKAGRISEFN GKTVSTIGSS
460 470 480 490 500
QLFIDPDFVE AEKLKNWFER EGKSVPCISL SREFSGSGKV DVRKTISQIK
510 520 530 540 550
DEKLGTSEKP DWITVSATIL YLKFDNFCYT ACPIMNGDRP CSKKVTDNGD
560 570 580 590 600
GTWRCEKCDK SVDECDYRYI LQLQIQDHTD LTCVTAFQEA GEEIMGISAK
610 620 630 640 650
DLYYVKNEHK DEEKFEDIIR KVAFTKYNFK LKVKEETFSD EQRVKATVVK
660 670 680 690 700
VDKLNYSADT RTMLGAMDKL RTRDANSLPI NPEGSDYNAD VVNTGIGSSG
710 720 730 740 750
TRDPSSVQRR DFGLHAHQSG QSGNHYSGGG ATTSCNVCGN SGHVSAKCPG
760 770 780
ATKPQEQGQY MGGSYRGTTG SYGGGLPRQH VGSY
Length:784
Mass (Da):85,992
Last modified:June 28, 2011 - v1
Checksum:i507E62118F205CB8
GO

Sequence cautioni

The sequence CAA16702 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB78915 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti643R → C in AF439837 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021687 Genomic DNA Translation: CAA16702.1 Sequence problems.
AL161550 Genomic DNA Translation: CAB78915.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE84147.1
AF439837 mRNA No translation available.
PIRiT04434
RefSeqiNP_567576.2, NM_118032.2
UniGeneiAt.26624
At.73929

Genome annotation databases

EnsemblPlantsiAT4G19130.1; AT4G19130.1; AT4G19130
AT4G19130.2; AT4G19130.2; AT4G19130
GeneIDi827651
GrameneiAT4G19130.1; AT4G19130.1; AT4G19130
AT4G19130.2; AT4G19130.2; AT4G19130
KEGGiath:AT4G19130

Similar proteinsi

Entry informationi

Entry nameiRFA1E_ARATH
AccessioniPrimary (citable) accession number: F4JSG3
Secondary accession number(s): O49671
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2013
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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