Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Disease resistance protein RPP5

Gene

RPP5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

TIR-NB-LRR receptor-like protein that confers resistance to the pathogen Hyaloperonospora arabidopsis isolate Noco2 (downy mildew disease) (PubMed:9212464). Confers resistance to H.arabidopsis isolates Emoy2, Emwa1 and Noco2 (PubMed:11846877).

GO - Molecular functioni

  • ADP binding Source: InterPro
  • ATP binding Source: UniProtKB-KW
  • nucleotide binding Source: TAIR

GO - Biological processi

  • defense response Source: TAIR
  • defense response to fungus, incompatible interaction Source: TAIR
  • signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Plant defense

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Disease resistance protein RPP5Curated
Alternative name(s):
Protein RECOGNITION OF PERONOSPORA PARASITICA 51 Publication
Gene namesi
Name:RPP51 Publication
Ordered Locus Names:At4g16950Imported
ORF Names:dl4505cImported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G16950.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14491449Disease resistance protein RPP5PRO_0000433380Add
BLAST

Proteomic databases

PaxDbiF4JNB7.
PRIDEiF4JNB7.

Expressioni

Gene expression databases

ExpressionAtlasiF4JNB7. baseline and differential.
GenevisibleiF4JNB7. AT.

Interactioni

Subunit structurei

Interacts with RSH1.2 Publications

Protein-protein interaction databases

STRINGi3702.AT4G16950.1.

Structurei

3D structure databases

ProteinModelPortaliF4JNB7.
SMRiF4JNB7. Positions 11-177, 639-681, 905-1154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 152143TIRPROSITE-ProRule annotationAdd
BLAST
Domaini192 – 446255NB-ARCSequence analysisAdd
BLAST
Repeati549 – 57325LRR 1Sequence analysisAdd
BLAST
Repeati574 – 59522LRR 2Sequence analysisAdd
BLAST
Repeati597 – 61822LRR 3Sequence analysisAdd
BLAST
Repeati619 – 64224LRR 4Sequence analysisAdd
BLAST
Repeati644 – 66522LRR 5Sequence analysisAdd
BLAST
Repeati687 – 71024LRR 6Sequence analysisAdd
BLAST
Repeati712 – 73221LRR 7Sequence analysisAdd
BLAST
Repeati733 – 75523LRR 8Sequence analysisAdd
BLAST
Repeati756 – 77924LRR 9Sequence analysisAdd
BLAST
Repeati802 – 82524LRR 10Sequence analysisAdd
BLAST
Repeati826 – 84924LRR 11Sequence analysisAdd
BLAST
Repeati915 – 93925LRR 12Sequence analysisAdd
BLAST
Repeati941 – 96222LRR 13Sequence analysisAdd
BLAST
Repeati963 – 98523LRR 14Sequence analysisAdd
BLAST
Repeati986 – 101126LRR 15Sequence analysisAdd
BLAST
Repeati1028 – 105225LRR 16Sequence analysisAdd
BLAST
Repeati1053 – 107725LRR 17Sequence analysisAdd
BLAST
Repeati1096 – 111924LRR 18Sequence analysisAdd
BLAST
Repeati1120 – 114324LRR 19Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 74Poly-SerSequence analysis

Sequence similaritiesi

Contains 19 LRR (leucine-rich) repeats.Sequence analysis
Contains 1 NB-ARC domain.Sequence analysis
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IGA8. Eukaryota.
COG4886. LUCA.
InParanoidiF4JNB7.
OMAiYLVELIM.
PhylomeDBiF4JNB7.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.40.50.300. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR011713. Leu-rich_rpt_3.
IPR002182. NB-ARC.
IPR027417. P-loop_NTPase.
IPR000157. TIR_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF07725. LRR_3. 3 hits.
PF00931. NB-ARC. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52058. SSF52058. 2 hits.
SSF52200. SSF52200. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According EST sequences.Curated

Isoform 1 (identifier: F4JNB7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASSSSGRR RYDVFPSFSG VDVRKTFLSH LIEALDGKSI NTFIDHGIER
60 70 80 90 100
SRTIAPELIS AIREARISIV IFSKNYASST WCLNELVEIH KCFNDLGQMV
110 120 130 140 150
IPVFYDVDPS EVRKQTGEFG KVFEKTCEVS KDKQPGDQKQ RWVQALTDIA
160 170 180 190 200
NIAGEDLLNG PNEAHMVEKI SNDVSNKLIT RSKCFDDFVG IEAHIEAIKS
210 220 230 240 250
VLCLESKEAR MVGIWGQSGI GKSTIGRALF SQLSIQFPLR AFLTYKSTSG
260 270 280 290 300
SDVSGMKLSW EKELLSEILG QKDIKIEHFG VVEQRLKHKK VLILLDDVDN
310 320 330 340 350
LEFLKTLVGK AEWFGSGSRI IVITQDRQFL KAHDIDLVYE VKLPSQGLAL
360 370 380 390 400
TMLCRSAFGK DSPPDDFKEL AFEVAKLAGH LPLGLNVLGS SLRRRGKKEW
410 420 430 440 450
MEMMPRLRNG LNGDIMKTLR VSYDRLHQKD QDMFLCIACL FNGFEVSYVK
460 470 480 490 500
DLLEDNVGLT MLSEKSLIRI TPDGHIEMHN LLEKLGREID RAKSKGNPGK
510 520 530 540 550
RQFLTNFEDI HEVVTEKTGT ETLLGIRLPF EEYFSTRPLL IDKESFKGMR
560 570 580 590 600
NLQYLKIGDW SDGGQPQSLV YLPLKLRLLD WDDCPLKSLP STFKAEYLVN
610 620 630 640 650
LIMKYSKLEK LWEGTLPLGS LKKMNLLCSK NLKEIPDLSN ARNLEELDLE
660 670 680 690 700
GCESLVTLPS SIQNAIKLRK LHCSGVILID LKSLEGMCNL EYLSVDCSRV
710 720 730 740 750
EGTQGIVYFP SKLRLLLWNN CPLKRLHSNF KVEYLVKLRM ENSDLEKLWD
760 770 780 790 800
GTQPLGRLKQ MFLRGSKYLK EIPDLSLAIN LEEVDICKCE SLVTFPSSMQ
810 820 830 840 850
NAIKLIYLDI SDCKKLESFP TDLNLESLEY LNLTGCPNLR NFPAIKMGCS
860 870 880 890 900
DVDFPEGRNE IVVEDCFWNK NLPAGLDYLD CLMRCMPCEF RPEYLVFLNV
910 920 930 940 950
RCYKHEKLWE GIQSLGSLEE MDLSESENLT EIPDLSKATN LKHLYLNNCK
960 970 980 990 1000
SLVTLPSTIG NLQKLVRLEM KECTGLEVLP TDVNLSSLET LDLSGCSSLR
1010 1020 1030 1040 1050
TFPLISKSIK WLYLENTAIE EILDLSKATK LESLILNNCK SLVTLPSTIG
1060 1070 1080 1090 1100
NLQNLRRLYM KRCTGLEVLP TDVNLSSLGI LDLSGCSSLR TFPLISTNIV
1110 1120 1130 1140 1150
WLYLENTAIG EVPCCIEDFT RLRVLLMYCC QRLKNISPNI FRLRSLMFAD
1160 1170 1180 1190 1200
FTDCRGVIKA LSDATVVATM EDSVSCVPLS ENIEYTCERF WGELYGDGDW
1210 1220 1230 1240 1250
DLGTEYFSFR NCFKLDRDAR ELILRSCFKP VALPGGEIPK YFTYRAYGDS
1260 1270 1280 1290 1300
LTVTLPRSSL SQSFLRFKAC LVVDPLSEGK GFYRYLEVNF GFNGKQYQKS
1310 1320 1330 1340 1350
FLEDEELEFC KTDHLFFCSF KFESEMTFND VEFKFCCSNR IKECGVRLMY
1360 1370 1380 1390 1400
VSQETEYNQQ TTRSKKRMRM TSGTSEEYIN LAGDQIVADT GLAALNMELS
1410 1420 1430 1440
LGEGEASSST SLEGEALSVD YMITKEQDED IPFLDPVSDG TWRSFYSAE
Length:1,449
Mass (Da):164,461
Last modified:June 28, 2011 - v1
Checksum:iA1CD42BD2D37D075
GO

Sequence cautioni

The sequence CAB46048.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAB80966.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti972 – 9721E → K in BAH19713 (PubMed:19423640).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97342 Genomic DNA. Translation: CAB46048.1. Sequence problems.
AL161545 Genomic DNA. Translation: CAB80966.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE83826.1.
AK226966 mRNA. Translation: BAE99034.1.
AK317019 mRNA. Translation: BAH19713.1.
PIRiB85189.
RefSeqiNP_193428.2. NM_117798.3. [F4JNB7-1]
UniGeneiAt.33039.
At.43768.
At.4449.
At.67198.
At.71837.

Genome annotation databases

EnsemblPlantsiAT4G16950.1; AT4G16950.1; AT4G16950. [F4JNB7-1]
GeneIDi827403.
KEGGiath:AT4G16950.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97342 Genomic DNA. Translation: CAB46048.1. Sequence problems.
AL161545 Genomic DNA. Translation: CAB80966.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE83826.1.
AK226966 mRNA. Translation: BAE99034.1.
AK317019 mRNA. Translation: BAH19713.1.
PIRiB85189.
RefSeqiNP_193428.2. NM_117798.3. [F4JNB7-1]
UniGeneiAt.33039.
At.43768.
At.4449.
At.67198.
At.71837.

3D structure databases

ProteinModelPortaliF4JNB7.
SMRiF4JNB7. Positions 11-177, 639-681, 905-1154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G16950.1.

Proteomic databases

PaxDbiF4JNB7.
PRIDEiF4JNB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G16950.1; AT4G16950.1; AT4G16950. [F4JNB7-1]
GeneIDi827403.
KEGGiath:AT4G16950.

Organism-specific databases

TAIRiAT4G16950.

Phylogenomic databases

eggNOGiENOG410IGA8. Eukaryota.
COG4886. LUCA.
InParanoidiF4JNB7.
OMAiYLVELIM.
PhylomeDBiF4JNB7.

Miscellaneous databases

PROiF4JNB7.

Gene expression databases

ExpressionAtlasiF4JNB7. baseline and differential.
GenevisibleiF4JNB7. AT.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.40.50.300. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR011713. Leu-rich_rpt_3.
IPR002182. NB-ARC.
IPR027417. P-loop_NTPase.
IPR000157. TIR_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF07725. LRR_3. 3 hits.
PF00931. NB-ARC. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52058. SSF52058. 2 hits.
SSF52200. SSF52200. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis thaliana."
    Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C., Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., Ridley P., Hudson S.-A., Patel K., Murphy G., Piffanelli P., Wedler H., Wedler E.
    , Wambutt R., Weitzenegger T., Pohl T., Terryn N., Gielen J., Villarroel R., De Clercq R., van Montagu M., Lecharny A., Aubourg S., Gy I., Kreis M., Lao N., Kavanagh T., Hempel S., Kotter P., Entian K.-D., Rieger M., Schaefer M., Funk B., Mueller-Auer S., Silvey M., James R., Monfort A., Pons A., Puigdomenech P., Douka A., Voukelatou E., Milioni D., Hatzopoulos P., Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A., Moores T., Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S., Ansorge W., Cooke R., Berger C., Delseny M., Voet M., Volckaert G., Mewes H.-W., Klosterman S., Schueller C., Chalwatzis N.
    Nature 391:485-488(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
    Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
    , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
    Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 549-1374.
    Strain: cv. Columbia.
  5. "Analysis of multiple occurrences of alternative splicing events in Arabidopsis thaliana using novel sequenced full-length cDNAs."
    Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M., Shinozaki K.
    DNA Res. 16:155-164(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 804-1449.
    Strain: cv. Columbia.
  6. "The Arabidopsis downy mildew resistance gene RPP5 shares similarity to the toll and interleukin-1 receptors with N and L6."
    Parker J.E., Coleman M.J., Szabo V., Frost L.N., Schmidt R., van der Biezen E.A., Moores T., Dean C., Daniels M.J., Jones J.D.
    Plant Cell 9:879-894(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Arabidopsis RelA/SpoT homologs implicate (p)ppGpp in plant signaling."
    van der Biezen E.A., Sun J., Coleman M.J., Bibb M.J., Jones J.D.
    Proc. Natl. Acad. Sci. U.S.A. 97:3747-3752(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RSH1.
  8. "Arabidopsis RPP4 is a member of the RPP5 multigene family of TIR-NB-LRR genes and confers downy mildew resistance through multiple signalling components."
    van der Biezen E.A., Freddie C.T., Kahn K., Parker J.E., Jones J.D.
    Plant J. 29:439-451(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RSH1.

Entry informationi

Entry nameiRPP5_ARATH
AccessioniPrimary (citable) accession number: F4JNB7
Secondary accession number(s): B9DG46, O23535, Q0WV14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 24, 2015
Last sequence update: June 28, 2011
Last modified: May 11, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.