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Protein

Diacylglycerol kinase 6

Gene

DGK6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Phosphorylates the second messenger diacylglycerol (DAG) to generate phosphatidic acid (PA), another important signaling molecule. PA is required for plant development and responses to abiotic stress and pathogen attack. May be involved in the accumulation of PA during cold stress.1 Publication

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processPlant defense, Stress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-114508 Effects of PIP2 hydrolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase 6 (EC:2.7.1.107)
Short name:
AtDGK6
Short name:
DAG kinase 6
Alternative name(s):
Diglyceride kinase 6
Short name:
DGK 6
Gene namesi
Name:DGK6
Ordered Locus Names:At4g28130
ORF Names:F26K10.10, T13J8.230
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G28130
TAIRilocus:2123703 AT4G28130

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004221141 – 466Diacylglycerol kinase 6Add BLAST466

Proteomic databases

PaxDbiF4JKI3

Expressioni

Gene expression databases

ExpressionAtlasiF4JKI3 baseline and differential
GenevisibleiF4JKI3 AT

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi3702.AT4G28130.1

Structurei

3D structure databases

ProteinModelPortaliF4JKI3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 194DAGKcPROSITE-ProRule annotationAdd BLAST152

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1169 Eukaryota
ENOG410XQVB LUCA
HOGENOMiHOG000241061
InParanoidiF4JKI3
KOiK00901
OMAiKFHKGAT
OrthoDBiEOG093608DB

Family and domain databases

Gene3Di3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR037607 DGK
IPR000756 Diacylglycerol_kin_accessory
IPR001206 Diacylglycerol_kinase_cat_dom
IPR016064 NAD/diacylglycerol_kinase_sf
PANTHERiPTHR11255 PTHR11255, 1 hit
PfamiView protein in Pfam
PF00609 DAGK_acc, 1 hit
PF00781 DAGK_cat, 1 hit
SMARTiView protein in SMART
SM00045 DAGKa, 1 hit
SM00046 DAGKc, 1 hit
SUPFAMiSSF111331 SSF111331, 2 hits
PROSITEiView protein in PROSITE
PS50146 DAGK, 1 hit

Sequencei

Sequence statusi: Complete.

F4JKI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQSETSMEK YKNLSDFLKK FFIPSYVLSP EDEPEAQISC TTAPENPILV
60 70 80 90 100
FINSKSGGQL GAELILTYRT LLNDKQVFDL EVETPDKVLQ RIYLNLERLK
110 120 130 140 150
DDSLASKIRD KLKIIVAGGD GTAGWLLGVV SDLNLSNPPP IATVPLGTGN
160 170 180 190 200
NLPFAFGWGK KNPGTDRSSV ESFLGKVINA KEMKIDNWKI LMRMKHPKEG
210 220 230 240 250
SCDITLKLPH SLPRIFPSDQ ENMEGYHTYR GGFWNYFSLG MDAQVSYAFH
260 270 280 290 300
SQRKLHPERF KNQLVNQSTY LKLSCTQGWF FASLFHPSSQ NIAKLAKIQI
310 320 330 340 350
CDRNGQWNDL HIPQSIRSIV CLNLPSFSGG LNPWGTPNPK KQRDRSLTAP
360 370 380 390 400
FVDDGLIEIV GFRNAWHGLI LLSPNGHGTR LAQANRVRLE FKKGAAKHAY
410 420 430 440 450
MRIDGEPWKQ PLPSNDETVM VEISHHGQVN MLATQNCRSK SMYESSSIIR
460
FSNDEDDSSV VENEEF
Length:466
Mass (Da):52,490
Last modified:June 28, 2011 - v1
Checksum:iC94BA5687CFFF252
GO

Sequence cautioni

The sequence CAB36781 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB79614 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB79615 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035524 Genomic DNA Translation: CAB36781.1 Sequence problems.
AL161572 Genomic DNA Translation: CAB79614.1 Sequence problems.
AL161572 Genomic DNA Translation: CAB79615.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE85443.1
PIRiC85327
D85327
T02913
T09029
RefSeqiNP_194542.2, NM_118953.2
UniGeneiAt.54533

Genome annotation databases

EnsemblPlantsiAT4G28130.1; AT4G28130.1; AT4G28130
GeneIDi828928
GrameneiAT4G28130.1; AT4G28130.1; AT4G28130
KEGGiath:AT4G28130

Similar proteinsi

Entry informationi

Entry nameiDGK6_ARATH
AccessioniPrimary (citable) accession number: F4JKI3
Secondary accession number(s): Q9M0J4, Q9SUC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: June 28, 2011
Last modified: April 25, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health