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F4JKI3

- DGK6_ARATH

UniProt

F4JKI3 - DGK6_ARATH

Protein

Diacylglycerol kinase 6

Gene

DGK6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Phosphorylates the second messenger diacylglycerol (DAG) to generate phosphatidic acid (PA), another important signaling molecule. PA is required for plant development and responses to abiotic stress and pathogen attack. May be involved in the accumulation of PA during cold stress.1 Publication

    Catalytic activityi

    ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. diacylglycerol kinase activity Source: UniProtKB-EC
    3. NAD+ kinase activity Source: InterPro

    GO - Biological processi

    1. defense response Source: UniProtKB-KW
    2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Plant defense, Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diacylglycerol kinase 6 (EC:2.7.1.107)
    Short name:
    AtDGK6
    Short name:
    DAG kinase 6
    Alternative name(s):
    Diglyceride kinase 6
    Short name:
    DGK 6
    Gene namesi
    Name:DGK6
    Ordered Locus Names:At4g28130
    ORF Names:F26K10.10, T13J8.230
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 4

    Organism-specific databases

    TAIRiAT4G28130.

    Subcellular locationi

    GO - Cellular componenti

    1. chloroplast Source: TAIR

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 466466Diacylglycerol kinase 6PRO_0000422114Add
    BLAST

    Proteomic databases

    PRIDEiF4JKI3.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi3702.AT4G28130.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliF4JKI3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 194152DAGKcPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DAGKc domain.PROSITE-ProRule annotation

    Phylogenomic databases

    KOiK00901.
    OMAiNDLHIPQ.

    Family and domain databases

    InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    [Graphical view]
    PfamiPF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    [Graphical view]
    SMARTiSM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 2 hits.
    PROSITEiPS50146. DAGK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F4JKI3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVQSETSMEK YKNLSDFLKK FFIPSYVLSP EDEPEAQISC TTAPENPILV    50
    FINSKSGGQL GAELILTYRT LLNDKQVFDL EVETPDKVLQ RIYLNLERLK 100
    DDSLASKIRD KLKIIVAGGD GTAGWLLGVV SDLNLSNPPP IATVPLGTGN 150
    NLPFAFGWGK KNPGTDRSSV ESFLGKVINA KEMKIDNWKI LMRMKHPKEG 200
    SCDITLKLPH SLPRIFPSDQ ENMEGYHTYR GGFWNYFSLG MDAQVSYAFH 250
    SQRKLHPERF KNQLVNQSTY LKLSCTQGWF FASLFHPSSQ NIAKLAKIQI 300
    CDRNGQWNDL HIPQSIRSIV CLNLPSFSGG LNPWGTPNPK KQRDRSLTAP 350
    FVDDGLIEIV GFRNAWHGLI LLSPNGHGTR LAQANRVRLE FKKGAAKHAY 400
    MRIDGEPWKQ PLPSNDETVM VEISHHGQVN MLATQNCRSK SMYESSSIIR 450
    FSNDEDDSSV VENEEF 466
    Length:466
    Mass (Da):52,490
    Last modified:June 28, 2011 - v1
    Checksum:iC94BA5687CFFF252
    GO

    Sequence cautioni

    The sequence CAB36781.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAB79614.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAB79615.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL035524 Genomic DNA. Translation: CAB36781.1. Sequence problems.
    AL161572 Genomic DNA. Translation: CAB79614.1. Sequence problems.
    AL161572 Genomic DNA. Translation: CAB79615.1. Sequence problems.
    CP002687 Genomic DNA. Translation: AEE85443.1.
    PIRiC85327.
    D85327.
    T02913.
    T09029.
    RefSeqiNP_194542.2. NM_118953.2.
    UniGeneiAt.54533.

    Genome annotation databases

    EnsemblPlantsiAT4G28130.1; AT4G28130.1; AT4G28130.
    GeneIDi828928.
    KEGGiath:AT4G28130.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL035524 Genomic DNA. Translation: CAB36781.1 . Sequence problems.
    AL161572 Genomic DNA. Translation: CAB79614.1 . Sequence problems.
    AL161572 Genomic DNA. Translation: CAB79615.1 . Sequence problems.
    CP002687 Genomic DNA. Translation: AEE85443.1 .
    PIRi C85327.
    D85327.
    T02913.
    T09029.
    RefSeqi NP_194542.2. NM_118953.2.
    UniGenei At.54533.

    3D structure databases

    ProteinModelPortali F4JKI3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT4G28130.1-P.

    Proteomic databases

    PRIDEi F4JKI3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT4G28130.1 ; AT4G28130.1 ; AT4G28130 .
    GeneIDi 828928.
    KEGGi ath:AT4G28130.

    Organism-specific databases

    TAIRi AT4G28130.

    Phylogenomic databases

    KOi K00901.
    OMAi NDLHIPQ.

    Family and domain databases

    InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    [Graphical view ]
    Pfami PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    [Graphical view ]
    SMARTi SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 2 hits.
    PROSITEi PS50146. DAGK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
      Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
      , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
      Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Rapid phosphatidic acid accumulation in response to low temperature stress in Arabidopsis is generated through diacylglycerol kinase."
      Arisz S.A., van Wijk R., Roels W., Zhu J.K., Haring M.A., Munnik T.
      Front. Plant Sci. 4:1-1(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiDGK6_ARATH
    AccessioniPrimary (citable) accession number: F4JKI3
    Secondary accession number(s): Q9M0J4, Q9SUC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2013
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3