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Protein

Protein IMPAIRED IN BABA-INDUCED STERILITY 1

Gene

IBS1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Required for beta-aminobutyric acid (BABA)-induced resistance (BABA-IR) against bacteria (e.g. P.syringae) and oomycetes (e.g. H.parasitica) via priming for salicylate (SA)-dependent defense responses such as pathogenesis-related PR-1 gene expression and trailing necrosis. Involved in BABA-mediated sterility (PubMed:15722464, PubMed:22209872). Necessary for the inheritance of BABA-priming to next generation, especially for the primed to be primed phenotype which consists in an enhanced second BABA-priming in transgenerationally primed plants (PubMed:22209872).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei160ATPPROSITE-ProRule annotation1
Active sitei255Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi137 – 145ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • defense response to bacterium Source: UniProtKB
  • defense response to oomycetes Source: UniProtKB
  • positive regulation of defense response to bacterium Source: UniProtKB
  • positive regulation of defense response to oomycetes Source: UniProtKB
  • protein phosphorylation Source: GO_Central
  • regulation of salicylic acid mediated signaling pathway Source: UniProtKB

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processPlant defense
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-674695. RNA Polymerase II Pre-transcription Events.
R-ATH-6796648. TP53 Regulates Transcription of DNA Repair Genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein IMPAIRED IN BABA-INDUCED STERILITY 11 Publication (EC:2.7.11.-PROSITE-ProRule annotation)
Gene namesi
Name:IBS11 Publication
Ordered Locus Names:At1g18670Imported
ORF Names:F6A14.22Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G18670.
TAIRilocus:2034944. AT1G18670.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Disruption phenotypei

Impaired in beta-aminobutyric acid (BABA)-induced sterility. Altered BABA-induced resistance (BABA-IR) against bacteria (e.g. P.syringae) and oomycetes (e.g. H.parasitica) associated with reduction in priming for salicylate (SA)-dependent defense responses (e.g. trailing necrosis and pathogenesis-related PR-1 gene expression) (PubMed:15722464, PubMed:22209872). Reduced primed to be primed phenotype in transgenerationally primed plants exposed to a second BABA-priming (PubMed:22209872).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00004412512 – 709Protein IMPAIRED IN BABA-INDUCED STERILITY 1Add BLAST708

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiF4ICB6.

Expressioni

Gene expression databases

ExpressionAtlasiF4ICB6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G18670.1.

Structurei

3D structure databases

ProteinModelPortaliF4ICB6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 418Protein kinasePROSITE-ProRule annotationAdd BLAST288

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi48 – 89Ser-richPROSITE-ProRule annotationAdd BLAST42

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0600. Eukaryota.
ENOG410XPIR. LUCA.
HOGENOMiHOG000233024.
InParanoidiF4ICB6.
OMAiRHESHIR.
OrthoDBiEOG093603XM.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.Imported
Isoform 1 (identifier: F4ICB6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGCVNSKQTV SVTPAIDHSG VFRDNVCSGS GRIVVEDLPP VTETKLLSWW
60 70 80 90 100
SKSGKKSSSK KSGSELGSDF GELSESGRAS SNCRSESVSF RLGNLSKYLE
110 120 130 140 150
AEQVAAGWPA WLSNVAGEAI HGWVPFRSDA FEKLEKIGQG TYSSVFRARE
160 170 180 190 200
TETGRIVALK KVRFDNFEPE SVRFMAREIL ILRKLNHPNI IKLEGIVTSK
210 220 230 240 250
LSCSIHLVFE YMEHDLTGLL SSPDIDFTTP QIKCYMKQLL SGLDHCHARG
260 270 280 290 300
VMHRDIKGSN LLVNNEGILK VADFGLANFC NASGNKQPLT SRVVTLWYRP
310 320 330 340 350
PELLLGATEY GASVDLWSVG CVFAELLIGK PVLQGRTEVE QLHKIFKLCG
360 370 380 390 400
SPPEDYWKKS KLPHAMLFKP QQHYDGCLRE TLKLKGLSDA DINLIETLLS
410 420 430 440 450
IQPHKRGTAS TALVSQYFTS KPFACDPSSL PVYSPSKEID AKHREDTTRK
460 470 480 490 500
KISGNGRRGT ESRKPTRKPP AFAKLAPAED VRHHSQKFQK RNGHSVHNSI
510 520 530 540 550
DSDSTLFEKM QKPSNHEKDE ASHVKNASQG DVPFSGPLQV SVSSGFAWAK
560 570 580 590 600
RRKDDICVRS HNRSLSRGHI PNLLGPSPAF SENTDVDSKN NEKEKEEKHG
610 620 630 640 650
ERTDSQDREA YEMLKLSMLK KWRQLERPDS FGGSDEYHSQ ELSLELYQRE
660 670 680 690 700
EKAAKLGHLG YEDNDEKIEF SGPLLSKSYG VDELLERHER QIRQLVRKSW

FQKGKKQGK
Length:709
Mass (Da):79,535
Last modified:June 28, 2011 - v1
Checksum:i4622C8C118FA9AEF
GO
Isoform 2 (identifier: F4ICB6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     660-662: GYE → VRL
     663-709: Missing.

Note: Derived from EST data. No experimental confirmation available.Imported
Show »
Length:662
Mass (Da):73,970
Checksum:iA3A5A200E09BE871
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_059055660 – 662GYE → VRL in isoform 2. 3
Alternative sequenceiVSP_059056663 – 709Missing in isoform 2. Add BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011809 Genomic DNA. Translation: AAF27112.1.
CP002684 Genomic DNA. Translation: AEE29744.1.
CP002684 Genomic DNA. Translation: ANM58799.1.
PIRiD86320.
RefSeqiNP_001321210.1. NM_001332357.1. [F4ICB6-2]
NP_173302.2. NM_101725.3. [F4ICB6-1]
UniGeneiAt.51667.

Genome annotation databases

EnsemblPlantsiAT1G18670.1; AT1G18670.1; AT1G18670. [F4ICB6-1]
AT1G18670.2; AT1G18670.2; AT1G18670. [F4ICB6-2]
GeneIDi838448.
GrameneiAT1G18670.1; AT1G18670.1; AT1G18670.
AT1G18670.2; AT1G18670.2; AT1G18670.
KEGGiath:AT1G18670.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiIBS1_ARATH
AccessioniPrimary (citable) accession number: F4ICB6
Secondary accession number(s): Q9M9T8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2017
Last sequence update: June 28, 2011
Last modified: October 25, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families