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Protein

Amine oxidase

Gene

At1g31690

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Protein has several cofactor binding sites:
  • L-topaquinoneUniRule annotation, Cu cationUniRule annotationNote: Contains 1 topaquinone per subunit.UniRule annotation
  • L-topaquinoneUniRule annotationNote: Contains 1 topaquinone per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei322Proton acceptorUniRule annotation1
Active sitei410Schiff-base intermediate with substrate; via topaquinoneUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-ATH-211945. Phase 1 - Functionalization of compounds.
R-ATH-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidaseUniRule annotation (EC:1.4.3.-UniRule annotation)
Gene namesi
Ordered Locus Names:At1g31690Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G31690.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500330959721 – 677Amine oxidaseSequence analysisAdd BLAST657

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4102',4',5'-topaquinoneUniRule annotation1

Post-translational modificationi

Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.UniRule annotation

Keywords - PTMi

TPQUniRule annotation

Proteomic databases

PaxDbiF4IAX0.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G31690.1.

Structurei

3D structure databases

ProteinModelPortaliF4IAX0.
SMRiF4IAX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 115Cu_amine_oxidN2InterPro annotationAdd BLAST89
Domaini123 – 215Cu_amine_oxidN3InterPro annotationAdd BLAST93
Domaini245 – 662Cu_amine_oxidInterPro annotationAdd BLAST418

Sequence similaritiesi

Belongs to the copper/topaquinone oxidase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1186. Eukaryota.
COG3733. LUCA.
InParanoidiF4IAX0.
KOiK00276.
OMAiEYVHTSE.
OrthoDBiEOG093605A3.

Family and domain databases

Gene3Di2.70.98.20. 1 hit.
InterProiIPR000269. Cu_amine_oxidase.
IPR015798. Cu_amine_oxidase_C.
IPR016182. Cu_amine_oxidase_N-reg.
IPR015800. Cu_amine_oxidase_N2.
IPR015802. Cu_amine_oxidase_N3.
[Graphical view]
PANTHERiPTHR10638. PTHR10638. 1 hit.
PfamiPF01179. Cu_amine_oxid. 1 hit.
PF02727. Cu_amine_oxidN2. 1 hit.
PF02728. Cu_amine_oxidN3. 1 hit.
[Graphical view]
SUPFAMiSSF49998. SSF49998. 1 hit.
SSF54416. SSF54416. 2 hits.
PROSITEiPS01165. COPPER_AMINE_OXID_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F4IAX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQVHLTIFI FSSIFVISSS SFIPPPHPFD PLTETELKLV RNIINKSYPI
60 70 80 90 100
GHNHKFTFQY VGLNEPEKSL VLSWHSSPDR NVKPPPRQAF VIARDKGMSR
110 120 130 140 150
EIVIDFSTRA IVSNKIHVGN GNPMLTIDEQ QAATAVVQKY KPFCDSIIKR
160 170 180 190 200
GLNLSEVVVT SSTMGWFGET KTKRFIRTIP FYLNGSVNTY LRPIEGMTII
210 220 230 240 250
VNLDQMKVTG FKDRFTGPMP KANGREYRIS KLKPPFGPSL RSAVVFQPDG
260 270 280 290 300
PGFKIDGHVV RWANWEFHMS FDVRAGLVIS LASIFDMDMN RYRQVLYKGH
310 320 330 340 350
LSEMFVPYMD PNDDWYFISY LDCGEFGCGQ TAVSLEPYTD CPPNAAFMDG
360 370 380 390 400
IFPGQDGTPT KISNVMCIFE KYAGDIMWRH TEAEVPGLKI TEVRPDVSLV
410 420 430 440 450
ARMVTTVGNY DYIIEYEFKP SGSIKMGVGL TGVLEVKPVE YVHTSEIKED
460 470 480 490 500
DIYGTIVADN TVGVNHDHFV TFRLDLDIDG TENSFVRTEL VTKRTPKSVN
510 520 530 540 550
TPRKSYWTTK RNTAKTEADA RVKLGLRAEE LVVVNPTKKT KHGNEVGYRL
560 570 580 590 600
LPGPASSPLL VQDDYPQIRA AFTNYNVWIT PYNKSEVWAS GLYADRSQGD
610 620 630 640 650
DTLAVWSQRD REIENKDIVM WYTVGFHHVP CQEDFPTMPT MFGGFELRPT
660 670
NFFEQNPVLK AKPFNLTTIP KCTTKNE
Length:677
Mass (Da):76,674
Last modified:June 28, 2011 - v1
Checksum:iA4A45980995368DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002684 Genomic DNA. Translation: AEE31383.1.
RefSeqiNP_174450.2. NM_102904.3.
UniGeneiAt.51862.

Genome annotation databases

EnsemblPlantsiAT1G31690.1; AT1G31690.1; AT1G31690.
GeneIDi840056.
GrameneiAT1G31690.1; AT1G31690.1; AT1G31690.
KEGGiath:AT1G31690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002684 Genomic DNA. Translation: AEE31383.1.
RefSeqiNP_174450.2. NM_102904.3.
UniGeneiAt.51862.

3D structure databases

ProteinModelPortaliF4IAX0.
SMRiF4IAX0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G31690.1.

Proteomic databases

PaxDbiF4IAX0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G31690.1; AT1G31690.1; AT1G31690.
GeneIDi840056.
GrameneiAT1G31690.1; AT1G31690.1; AT1G31690.
KEGGiath:AT1G31690.

Organism-specific databases

TAIRiAT1G31690.

Phylogenomic databases

eggNOGiKOG1186. Eukaryota.
COG3733. LUCA.
InParanoidiF4IAX0.
KOiK00276.
OMAiEYVHTSE.
OrthoDBiEOG093605A3.

Enzyme and pathway databases

ReactomeiR-ATH-211945. Phase 1 - Functionalization of compounds.
R-ATH-6798695. Neutrophil degranulation.

Family and domain databases

Gene3Di2.70.98.20. 1 hit.
InterProiIPR000269. Cu_amine_oxidase.
IPR015798. Cu_amine_oxidase_C.
IPR016182. Cu_amine_oxidase_N-reg.
IPR015800. Cu_amine_oxidase_N2.
IPR015802. Cu_amine_oxidase_N3.
[Graphical view]
PANTHERiPTHR10638. PTHR10638. 1 hit.
PfamiPF01179. Cu_amine_oxid. 1 hit.
PF02727. Cu_amine_oxidN2. 1 hit.
PF02728. Cu_amine_oxidN3. 1 hit.
[Graphical view]
SUPFAMiSSF49998. SSF49998. 1 hit.
SSF54416. SSF54416. 2 hits.
PROSITEiPS01165. COPPER_AMINE_OXID_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF4IAX0_ARATH
AccessioniPrimary (citable) accession number: F4IAX0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 30, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.