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Protein

Myosin-8

Gene

XI-B

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi156 – 1638ATPSequence analysis
Nucleotide bindingi210 – 2189ATPSequence analysis

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • motor activity Source: TAIR

GO - Biological processi

  • actin filament-based movement Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-8
Alternative name(s):
Myosin XI B
Short name:
AtXIB
Gene namesi
Name:XI-B
Synonyms:XIB
Ordered Locus Names:At1g04160
ORF Names:F20D22.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G04160.

Subcellular locationi

  • Cytoplasm 1 Publication

  • Note: Colocalizes with cytoplasmic vesicles and/or organelles.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15001500Myosin-8PRO_0000422863Add
BLAST

Proteomic databases

PaxDbiF4I460.
PRIDEiF4I460.

PTM databases

iPTMnetiF4I460.

Expressioni

Gene expression databases

GenevisibleiF4I460. AT.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi24481. 1 interaction.
STRINGi3702.AT1G04160.1.

Structurei

3D structure databases

ProteinModelPortaliF4I460.
SMRiF4I460. Positions 3-879, 1272-1466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 732671Myosin motorAdd
BLAST
Domaini735 – 76430IQ 1PROSITE-ProRule annotationAdd
BLAST
Domaini758 – 78730IQ 2PROSITE-ProRule annotationAdd
BLAST
Domaini783 – 81230IQ 3PROSITE-ProRule annotationAdd
BLAST
Domaini806 – 83530IQ 4PROSITE-ProRule annotationAdd
BLAST
Domaini831 – 86030IQ 5PROSITE-ProRule annotationAdd
BLAST
Domaini854 – 88330IQ 6PROSITE-ProRule annotationAdd
BLAST
Domaini1146 – 1447302DilutePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni496 – 53035Actin-bindingSequence analysisAdd
BLAST
Regioni532 – 55524Actin-bindingSequence analysisAdd
BLAST
Regioni590 – 61324Actin-bindingSequence analysisAdd
BLAST
Regioni613 – 63523Actin-bindingBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili884 – 1049166Sequence analysisAdd
BLAST

Domaini

IQ domain mediates interaction with calmodulin.By similarity
The tail domain is a globular cargo-binding domain.By similarity

Sequence similaritiesi

Contains 1 dilute domain.PROSITE-ProRule annotation
Contains 6 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0160. Eukaryota.
COG5022. LUCA.
HOGENOMiHOG000029608.
InParanoidiF4I460.
OMAiFADRYHI.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR002710. Dilute_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01843. DIL. 1 hit.
PF00612. IQ. 6 hits.
PF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM01132. DIL. 1 hit.
SM00015. IQ. 6 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51126. DILUTE. 1 hit.
PS50096. IQ. 5 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F4I460-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVATFNPAVG SHVWVEDPDE AWLDGEVVEI NGDQIKVLCA SGKQVVVKDS
60 70 80 90 100
NIYPKDVEAP ASGVEDMTRL AYLHEPGVLQ NLQSRYDINE IYTYTGSILI
110 120 130 140 150
AVNPFRRLPH LYSSHMMTQY KGASLGELSP HPFAVADAAY RQMVNEGVSQ
160 170 180 190 200
SILVSGESGA GKTESTKLLM RYLAFMGGRG AATEGRTVEQ KVLESNPVLE
210 220 230 240 250
AFGNAKTVKN NNSSRFGKFV EIQFDQSGRI SGAAIRTYLL ERSRVCQVSD
260 270 280 290 300
PERNYHCFYM LCAAPEEDAK KFKLGDPKIY HYLNQSKCIQ LDAMNDAEEY
310 320 330 340 350
HATKKAMDVV GISSEEQDAI FRVVASILHL GNIEFAKGTE IDSSIPRDEK
360 370 380 390 400
SWFHLKTAAE LLMCNEKSLE DSLCKRIMAT RDETITKTLD PEAALLSRDA
410 420 430 440 450
LAKVMYSRLF DWLVEKINTS IGQDPDSKYL IGVLDIYGFE SFKTNSFEQF
460 470 480 490 500
CINLTNEKLQ QHFNQHVFKM EQEEYKKEEI NWSYIEFVDN QDILDLIEKK
510 520 530 540 550
PGGIIALLDE ACMFPRSTHE TFAQKLYQTY KNHKRFTKPK LARSDFTICH
560 570 580 590 600
YAGDVTYQTE LFLDKNKDYV IAEHQALLNA STCSFVANLF PPVSDDSKQS
610 620 630 640 650
KFSSIGTRFK QQLVSLLEIL NTTEPHYIRC IKPNNLLKPG IFENQNVLQQ
660 670 680 690 700
LRCGGVMEAI RISCAGYPTR KHFDEFLNRF GIIAPQVLDK NSNEPAACKK
710 720 730 740 750
LLDKAGLEGY QIGKSKVFLR AGQMADLDTR RTEILGRSAS IIQRKVRSYL
760 770 780 790 800
AQKTFIQLRI SATQIQAVCR GYLARSIYEG MRREAAALKI QRDLRKFLAR
810 820 830 840 850
KAYTELFSAT ILIQAGMRGM VSRKELCLRR QTKAATIIQT RCRVYLARLH
860 870 880 890 900
YRKLKKAAIT TQCAWRGKVA RKELKNLKMA ARETGALQEA KNKLEKQVEE
910 920 930 940 950
LTWRLQLEKR MRTDLEEAKK QENAKYESSL EEIQNKFKET EALLIKEREA
960 970 980 990 1000
AKTVSEVLPI IKEVPVVDQE LMEKLTNENE KLKGMVSSLE IKIDETAKEL
1010 1020 1030 1040 1050
HETARISQDR LKQALAAESK VAKLKTAMQR LEEKISDMET EKQIMLQQTI
1060 1070 1080 1090 1100
LNTPVKSVAG HPPTATIKNL ENGHRTNLEN QFNEVEVNGN AGKSAAERQL
1110 1120 1130 1140 1150
ENVDTLIDCV KENIGFSNGK PIAAFTIYKC LLHWKCFESE KTSAFDRLIE
1160 1170 1180 1190 1200
MIGSAIENED DNGHLAYWLT NTSALLFLLQ KSLKPAGAGA TASKKPPITT
1210 1220 1230 1240 1250
SLFGRMALSF RSSPNLAAAA EAAALAVIRP VEAKYPALLF KQQLAAYVEK
1260 1270 1280 1290 1300
IFGMIRDNLK KELSALISMC IQAPRISKGG IQRSARSLGK DSPAIHWQSI
1310 1320 1330 1340 1350
IDGLNSLLAI LKDNYVPLVL IQKIHTQTFS FVNVQLFNSL LLRKECCTFS
1360 1370 1380 1390 1400
NGEFVKSGLA ELELWCGQVN EYAGPSWDEL KHIRQAVGFL VIHQKYRVSY
1410 1420 1430 1440 1450
DDIVHDLCPI LSVQQLYRIC TLYWDDCYNT RSVSQEVISS MRALMTEESN
1460 1470 1480 1490 1500
DADSNSFLLD DNSSIPFSID EISNSMHEKD FASVKPAKEL LENPEFVFLH
Length:1,500
Mass (Da):169,493
Last modified:June 28, 2011 - v1
Checksum:iD8A0EE1A24BB4BFC
GO

Sequence cautioni

The sequence AAC16753.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002411 Genomic DNA. Translation: AAC16753.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE27664.1.
PIRiT00957.
RefSeqiNP_171912.2. NM_100297.2.
UniGeneiAt.42479.

Genome annotation databases

EnsemblPlantsiAT1G04160.1; AT1G04160.1; AT1G04160.
GeneIDi839246.
GrameneiAT1G04160.1; AT1G04160.1; AT1G04160.
KEGGiath:AT1G04160.

Cross-referencesi

Web resourcesi

The Myosin Home Page (MHP)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002411 Genomic DNA. Translation: AAC16753.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE27664.1.
PIRiT00957.
RefSeqiNP_171912.2. NM_100297.2.
UniGeneiAt.42479.

3D structure databases

ProteinModelPortaliF4I460.
SMRiF4I460. Positions 3-879, 1272-1466.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi24481. 1 interaction.
STRINGi3702.AT1G04160.1.

PTM databases

iPTMnetiF4I460.

Proteomic databases

PaxDbiF4I460.
PRIDEiF4I460.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G04160.1; AT1G04160.1; AT1G04160.
GeneIDi839246.
GrameneiAT1G04160.1; AT1G04160.1; AT1G04160.
KEGGiath:AT1G04160.

Organism-specific databases

TAIRiAT1G04160.

Phylogenomic databases

eggNOGiKOG0160. Eukaryota.
COG5022. LUCA.
HOGENOMiHOG000029608.
InParanoidiF4I460.
OMAiFADRYHI.

Miscellaneous databases

PROiF4I460.

Gene expression databases

GenevisibleiF4I460. AT.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR002710. Dilute_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01843. DIL. 1 hit.
PF00612. IQ. 6 hits.
PF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM01132. DIL. 1 hit.
SM00015. IQ. 6 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51126. DILUTE. 1 hit.
PS50096. IQ. 5 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "A myosin family tree."
    Hodge T., Cope M.J.
    J. Cell Sci. 113:3353-3354(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.
  4. "Analysis of the myosins encoded in the recently completed Arabidopsis thaliana genome sequence."
    Reddy A.S., Day I.S.
    Genome Biol. 2:RESEARCH0024.1-RESEARCH0024.17(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.
  5. "Association of six YFP-myosin XI-tail fusions with mobile plant cell organelles."
    Reisen D., Hanson M.R.
    BMC Plant Biol. 7:6-6(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. "Two class XI myosins function in organelle trafficking and root hair development in Arabidopsis."
    Peremyslov V.V., Prokhnevsky A.I., Avisar D., Dolja V.V.
    Plant Physiol. 146:1109-1116(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  7. "Overlapping functions of the four class XI myosins in Arabidopsis growth, root hair elongation, and organelle motility."
    Prokhnevsky A.I., Peremyslov V.V., Dolja V.V.
    Proc. Natl. Acad. Sci. U.S.A. 105:19744-19749(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  8. "Class XI myosins are required for development, cell expansion, and F-Actin organization in Arabidopsis."
    Peremyslov V.V., Prokhnevsky A.I., Dolja V.V.
    Plant Cell 22:1883-1897(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiMYO8_ARATH
AccessioniPrimary (citable) accession number: F4I460
Secondary accession number(s): O64491
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2013
Last sequence update: June 28, 2011
Last modified: May 11, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.