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Protein

GMP synthase [glutamine-hydrolyzing] subunit B

Gene

guaAB

Organism
Pyrococcus sp. (strain NA2)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of GMP from XMP.UniRule annotation

Catalytic activityi

ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.UniRule annotation

Pathwayi: GMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes GMP from XMP (L-Gln route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GMP synthase [glutamine-hydrolyzing] subunit A (guaAA), GMP synthase [glutamine-hydrolyzing] subunit B (guaAB)
This subpathway is part of the pathway GMP biosynthesis, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes GMP from XMP (L-Gln route), the pathway GMP biosynthesis and in Purine metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 34ATPPROSITE-ProRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation
Biological processGMP biosynthesisUniRule annotation, Purine biosynthesis
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciPSP342949:G1GX4-1992-MONOMER
UniPathwayiUPA00189; UER00296

Names & Taxonomyi

Protein namesi
Recommended name:
GMP synthase [glutamine-hydrolyzing] subunit BUniRule annotation (EC:6.3.5.2UniRule annotation)
Alternative name(s):
GMP synthetaseUniRule annotation
Gene namesi
Name:guaABUniRule annotation
Ordered Locus Names:PNA2_1923Imported
OrganismiPyrococcus sp. (strain NA2)Imported
Taxonomic identifieri342949 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000008293 Componenti: Chromosome

Interactioni

Subunit structurei

Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).UniRule annotation

Protein-protein interaction databases

STRINGi342949.PNA2_1923

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 185GMPS ATP-PPaseInterPro annotationAdd BLAST185

Phylogenomic databases

eggNOGiarCOG00085 Archaea
COG0519 LUCA
KOiK01951
OMAiEGGIKSH
OrthoDBiPOG093Z04V2

Family and domain databases

CDDicd01997 GMP_synthase_C, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00345 GMP_synthase_B, 1 hit
InterProiView protein in InterPro
IPR001674 GMP_synth_C
IPR026598 GMP_synthase_B
IPR025777 GMPS_ATP_PPase_dom
IPR022310 NAD/GMP_synthase
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00958 GMP_synt_C, 1 hit
PF02540 NAD_synthase, 2 hits
TIGRFAMsiTIGR00884 guaA_Cterm, 1 hit
PROSITEiView protein in PROSITE
PS51553 GMPS_ATP_PPASE, 1 hit

Sequencei

Sequence statusi: Complete.

F4HLN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWGKFVEEK VREIRETVGN SKAIIALSGG VDSSTAAVLA YKAIGDRLHA
60 70 80 90 100
VFVNTGFLRK GEPEFVVKTF RDEFGMNLHY VDAQDRFFSA LKGVTDPEEK
110 120 130 140 150
RKIIGRVFIE VFEEVAREIG AEYLIQGTIA PDWIESQGKI KSHHNVGGLP
160 170 180 190 200
ERLNLKLIEP LRDLYKDEVR ELAKFLGLPE KIYNRMPFPG PGLAVRVIGE
210 220 230 240 250
VTPEKIRIVR EANAIVEEEV EKAGLRPWQA FAVLLGVKTV GVQGDIRAYK
260 270 280 290 300
ETIAVRIVES TDGMTANAMN VPWEVLQRIA FRITSEIPEV GRVLYDITNK

PPATIEFE
Length:308
Mass (Da):34,576
Last modified:June 28, 2011 - v1
Checksum:i3ABB82326F10A130
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002670 Genomic DNA Translation: AEC52837.1
RefSeqiWP_013749387.1, NC_015474.1

Genome annotation databases

EnsemblBacteriaiAEC52837; AEC52837; PNA2_1923
GeneIDi10555420
KEGGipyn:PNA2_1923
PATRICifig|342949.8.peg.1939

Similar proteinsi

Entry informationi

Entry nameiF4HLN4_PYRSN
AccessioniPrimary (citable) accession number: F4HLN4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: March 28, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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