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F4HKU8

- F4HKU8_PYRSN

UniProt

F4HKU8 - F4HKU8_PYRSN

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Protein

Phosphoenolpyruvate carboxylase

Gene

ppcA

Organism
Pyrococcus sp. (strain NA2)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Note: Magnesium.UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

BioCyciPSP342949:GI74-551-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcAUniRule annotation
Ordered Locus Names:PNA2_0537Imported
OrganismiPyrococcus sp. (strain NA2)Imported
Taxonomic identifieri342949 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000008293: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 2 family.UniRule annotation

Phylogenomic databases

KOiK01595.
OMAiDEYMPDY.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

F4HKU8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIPRIMSTQH PDNYSIPFFA SSPVLGGDDE ITEAFYAFSV LGADEQMWDF
60 70 80 90 100
EGKEVDEFVV KKLLERYSMF FKKVILGKDV RITPRVPNPS VEKAEAKLLI
110 120 130 140 150
ETLQGITRAA DYAKVFYEDD IAPIFEVILP MTTSLAEIER VYMLYKRIVE
160 170 180 190 200
LANEVIYDVT VREWIGDFYP KEIGVIPLFE TKVALLKSAK IVKDYISRRR
210 220 230 240 250
NIEYMRVFFA RSDPAMNYGL ISAVTYVKKA LYEMFKVEDS LSIPIYPIIG
260 270 280 290 300
VGGPPFRGGM RPDNVENVVR EYPSVQTYTI QSSFKYDHPT KEVVKAVEFV
310 320 330 340 350
KSTKRREPHF VDIPDFIQLY EVEYQRQIKI LAPHIRRVVT RIPDRRRRKL
360 370 380 390 400
HIGLFGYSRR IGDMALPRAI KFTASLYSIG IPPELLALNA LSDKQLDIVS
410 420 430 440 450
EYYKNVYEDL EFAMRFFSFK VAESVGLKEL VERIKEFKPE INEEYVSEAE
460 470
QVFRGQGDVI KLAQIRGFLG
Length:470
Mass (Da):54,363
Last modified:June 28, 2011 - v1
Checksum:iBC4CF3D86D84A4CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002670 Genomic DNA. Translation: AEC51453.1.
RefSeqiWP_013748008.1. NC_015474.1.
YP_004423457.1. NC_015474.1.

Genome annotation databases

EnsemblBacteriaiAEC51453; AEC51453; PNA2_0537.
GeneIDi10554004.
KEGGipyn:PNA2_0537.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002670 Genomic DNA. Translation: AEC51453.1 .
RefSeqi WP_013748008.1. NC_015474.1.
YP_004423457.1. NC_015474.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEC51453 ; AEC51453 ; PNA2_0537 .
GeneIDi 10554004.
KEGGi pyn:PNA2_0537.

Phylogenomic databases

KOi K01595.
OMAi DEYMPDY.

Enzyme and pathway databases

BioCyci PSP342949:GI74-551-MONOMER.

Family and domain databases

HAMAPi MF_01904. PEPcase_type2.
InterProi IPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF14010. PEPcase_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF006677. UCP006677. 1 hit.
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR02751. PEPCase_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of hyperthermophilic Pyrococcus sp. strain NA2, isolated from a deep-sea hydrothermal vent area."
    Lee H.S., Bae S.S., Kim M.S., Kwon K.K., Kang S.G., Lee J.H.
    J. Bacteriol. 193:3666-3667(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NA2Imported.

Entry informationi

Entry nameiF4HKU8_PYRSN
AccessioniPrimary (citable) accession number: F4HKU8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 26, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3