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F4HKU8

- F4HKU8_PYRSN

UniProt

F4HKU8 - F4HKU8_PYRSN

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Protein

Phosphoenolpyruvate carboxylase

Gene
ppcA, PNA2_0537
Organism
Pyrococcus sp. (strain NA2)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

BioCyciPSP342949:GI74-551-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcAUniRule annotation
Ordered Locus Names:PNA2_0537Imported
OrganismiPyrococcus sp. (strain NA2)Imported
Taxonomic identifieri342949 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000008293: Chromosome

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 2 family.UniRule annotation

Phylogenomic databases

KOiK01595.
OMAiDEYMPDY.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

F4HKU8-1 [UniParc]FASTAAdd to Basket

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MIPRIMSTQH PDNYSIPFFA SSPVLGGDDE ITEAFYAFSV LGADEQMWDF    50
EGKEVDEFVV KKLLERYSMF FKKVILGKDV RITPRVPNPS VEKAEAKLLI 100
ETLQGITRAA DYAKVFYEDD IAPIFEVILP MTTSLAEIER VYMLYKRIVE 150
LANEVIYDVT VREWIGDFYP KEIGVIPLFE TKVALLKSAK IVKDYISRRR 200
NIEYMRVFFA RSDPAMNYGL ISAVTYVKKA LYEMFKVEDS LSIPIYPIIG 250
VGGPPFRGGM RPDNVENVVR EYPSVQTYTI QSSFKYDHPT KEVVKAVEFV 300
KSTKRREPHF VDIPDFIQLY EVEYQRQIKI LAPHIRRVVT RIPDRRRRKL 350
HIGLFGYSRR IGDMALPRAI KFTASLYSIG IPPELLALNA LSDKQLDIVS 400
EYYKNVYEDL EFAMRFFSFK VAESVGLKEL VERIKEFKPE INEEYVSEAE 450
QVFRGQGDVI KLAQIRGFLG 470
Length:470
Mass (Da):54,363
Last modified:June 28, 2011 - v1
Checksum:iBC4CF3D86D84A4CD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002670 Genomic DNA. Translation: AEC51453.1.
RefSeqiWP_013748008.1. NC_015474.1.
YP_004423457.1. NC_015474.1.

Genome annotation databases

EnsemblBacteriaiAEC51453; AEC51453; PNA2_0537.
GeneIDi10554004.
KEGGipyn:PNA2_0537.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002670 Genomic DNA. Translation: AEC51453.1 .
RefSeqi WP_013748008.1. NC_015474.1.
YP_004423457.1. NC_015474.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEC51453 ; AEC51453 ; PNA2_0537 .
GeneIDi 10554004.
KEGGi pyn:PNA2_0537.

Phylogenomic databases

KOi K01595.
OMAi DEYMPDY.

Enzyme and pathway databases

BioCyci PSP342949:GI74-551-MONOMER.

Family and domain databases

HAMAPi MF_01904. PEPcase_type2.
InterProi IPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF14010. PEPcase_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF006677. UCP006677. 1 hit.
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR02751. PEPCase_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of hyperthermophilic Pyrococcus sp. strain NA2, isolated from a deep-sea hydrothermal vent area."
    Lee H.S., Bae S.S., Kim M.S., Kwon K.K., Kang S.G., Lee J.H.
    J. Bacteriol. 193:3666-3667(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NA2Imported.

Entry informationi

Entry nameiF4HKU8_PYRSN
AccessioniPrimary (citable) accession number: F4HKU8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 3, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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