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F4HKU8

- F4HKU8_PYRSN

UniProt

F4HKU8 - F4HKU8_PYRSN

Protein

Phosphoenolpyruvate carboxylase

Gene

ppcA

Organism
Pyrococcus sp. (strain NA2)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 15 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

    Catalytic activityi

    Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbon fixation Source: UniProtKB-HAMAP
    2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
    3. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    LyaseUniRule annotation

    Keywords - Biological processi

    Carbon dioxide fixationUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, PyruvateImported

    Enzyme and pathway databases

    BioCyciPSP342949:GI74-551-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
    Short name:
    PEPCUniRule annotation
    Short name:
    PEPCaseUniRule annotation
    Gene namesi
    Name:ppcAUniRule annotation
    Ordered Locus Names:PNA2_0537Imported
    OrganismiPyrococcus sp. (strain NA2)Imported
    Taxonomic identifieri342949 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000008293: Chromosome

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PEPCase type 2 family.UniRule annotation

    Phylogenomic databases

    KOiK01595.
    OMAiDEYMPDY.

    Family and domain databases

    HAMAPiMF_01904. PEPcase_type2.
    InterProiIPR007566. PEP_COase_arc-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PfamiPF14010. PEPcase_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006677. UCP006677. 1 hit.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F4HKU8-1 [UniParc]FASTAAdd to Basket

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    MIPRIMSTQH PDNYSIPFFA SSPVLGGDDE ITEAFYAFSV LGADEQMWDF    50
    EGKEVDEFVV KKLLERYSMF FKKVILGKDV RITPRVPNPS VEKAEAKLLI 100
    ETLQGITRAA DYAKVFYEDD IAPIFEVILP MTTSLAEIER VYMLYKRIVE 150
    LANEVIYDVT VREWIGDFYP KEIGVIPLFE TKVALLKSAK IVKDYISRRR 200
    NIEYMRVFFA RSDPAMNYGL ISAVTYVKKA LYEMFKVEDS LSIPIYPIIG 250
    VGGPPFRGGM RPDNVENVVR EYPSVQTYTI QSSFKYDHPT KEVVKAVEFV 300
    KSTKRREPHF VDIPDFIQLY EVEYQRQIKI LAPHIRRVVT RIPDRRRRKL 350
    HIGLFGYSRR IGDMALPRAI KFTASLYSIG IPPELLALNA LSDKQLDIVS 400
    EYYKNVYEDL EFAMRFFSFK VAESVGLKEL VERIKEFKPE INEEYVSEAE 450
    QVFRGQGDVI KLAQIRGFLG 470
    Length:470
    Mass (Da):54,363
    Last modified:June 28, 2011 - v1
    Checksum:iBC4CF3D86D84A4CD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002670 Genomic DNA. Translation: AEC51453.1.
    RefSeqiWP_013748008.1. NC_015474.1.
    YP_004423457.1. NC_015474.1.

    Genome annotation databases

    EnsemblBacteriaiAEC51453; AEC51453; PNA2_0537.
    GeneIDi10554004.
    KEGGipyn:PNA2_0537.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002670 Genomic DNA. Translation: AEC51453.1 .
    RefSeqi WP_013748008.1. NC_015474.1.
    YP_004423457.1. NC_015474.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEC51453 ; AEC51453 ; PNA2_0537 .
    GeneIDi 10554004.
    KEGGi pyn:PNA2_0537.

    Phylogenomic databases

    KOi K01595.
    OMAi DEYMPDY.

    Enzyme and pathway databases

    BioCyci PSP342949:GI74-551-MONOMER.

    Family and domain databases

    HAMAPi MF_01904. PEPcase_type2.
    InterProi IPR007566. PEP_COase_arc-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    Pfami PF14010. PEPcase_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006677. UCP006677. 1 hit.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    TIGRFAMsi TIGR02751. PEPCase_arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of hyperthermophilic Pyrococcus sp. strain NA2, isolated from a deep-sea hydrothermal vent area."
      Lee H.S., Bae S.S., Kim M.S., Kwon K.K., Kang S.G., Lee J.H.
      J. Bacteriol. 193:3666-3667(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NA2Imported.

    Entry informationi

    Entry nameiF4HKU8_PYRSN
    AccessioniPrimary (citable) accession number: F4HKU8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3