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F4HJW7

- F4HJW7_PYRSN

UniProt

F4HJW7 - F4HJW7_PYRSN

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Protein

Ribulose bisphosphate carboxylase

Gene
rbcL, PNA2_1620
Organism
Pyrococcus sp. (strain NA2)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase By similarity.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei153 – 1531Proton acceptor By similarityUniRule annotation
Binding sitei155 – 1551Substrate By similarityUniRule annotation
Metal bindingi179 – 1791Magnesium; via carbamate group By similarityUniRule annotation
Metal bindingi181 – 1811Magnesium By similarityUniRule annotation
Metal bindingi182 – 1821Magnesium By similarityUniRule annotation
Active sitei271 – 2711Proton acceptor By similarityUniRule annotation
Binding sitei272 – 2721Substrate By similarityUniRule annotation
Binding sitei304 – 3041Substrate By similarityUniRule annotation
Sitei311 – 3111Transition state stabilizer By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. oxidoreductase activity Source: UniProtKB-KW
  3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. AMP catabolic process Source: UniProtKB-HAMAP
  2. carbon fixation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciPSP342949:GI74-1654-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotation
Ordered Locus Names:PNA2_1620Imported
OrganismiPyrococcus sp. (strain NA2)Imported
Taxonomic identifieri342949 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000008293: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei179 – 1791N6-carboxylysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF4HJW7.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni341 – 3433Substrate binding By similarityUniRule annotation
Regioni363 – 3664Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK01601.
OMAiFTQDWAS.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01133. RuBisCO_L_type3.
InterProiIPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.

Sequencei

Sequence statusi: Complete.

F4HJW7-1 [UniParc]FASTAAdd to Basket

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MEWYLDFVDL DYTPGRDELI VEYYFEPNGV SPEEAAGRIA SESSIGTWTT    50
LWKLPEMAKR SIAKVFYLEK HGEGYIAKIA YPLTLFEEGS LVQLFSAIAG 100
NVFGMKALKN LRLLDFHPPY EYLRHFKGPQ FGVHGIREFM GVKDRPLTAT 150
VPKPKMGWSV EEYAEIAYEL WSGGIDLLKD DENFTSFPFN RFEERVRKLY 200
RVRDKVEEET GETKEYLINI TGPVHVMEKR AELVACEGGR YVMIDIVVVG 250
WSALQYMREI TEDLGLAIHA HRAMHAAFTR NPRHGITMLA LAKAARMIGV 300
DQIHTGTAVG KMAGDYEEIK RINDFLLSKW EHIRPVFPVA SGGLHPGLMP 350
ELIRLFGKDL VIQAGGGVMG HPDGPRAGAK ALRDAIEAAV EGVDLEEKAK 400
SSPELKKALE KWGYLKPK 418
Length:418
Mass (Da):47,086
Last modified:June 28, 2011 - v1
Checksum:iF355A0BB4552D10E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002670 Genomic DNA. Translation: AEC52535.1.
RefSeqiWP_013749085.1. NC_015474.1.
YP_004424539.1. NC_015474.1.

Genome annotation databases

EnsemblBacteriaiAEC52535; AEC52535; PNA2_1620.
GeneIDi10555107.
KEGGipyn:PNA2_1620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002670 Genomic DNA. Translation: AEC52535.1 .
RefSeqi WP_013749085.1. NC_015474.1.
YP_004424539.1. NC_015474.1.

3D structure databases

ProteinModelPortali F4HJW7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEC52535 ; AEC52535 ; PNA2_1620 .
GeneIDi 10555107.
KEGGi pyn:PNA2_1620.

Phylogenomic databases

KOi K01601.
OMAi FTQDWAS.

Enzyme and pathway databases

BioCyci PSP342949:GI74-1654-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPi MF_01133. RuBisCO_L_type3.
InterProi IPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of hyperthermophilic Pyrococcus sp. strain NA2, isolated from a deep-sea hydrothermal vent area."
    Lee H.S., Bae S.S., Kim M.S., Kwon K.K., Kang S.G., Lee J.H.
    J. Bacteriol. 193:3666-3667(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NA2Imported.

Entry informationi

Entry nameiF4HJW7_PYRSN
AccessioniPrimary (citable) accession number: F4HJW7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 3, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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