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Protein

Threonine--tRNA ligase

Gene

thrS

Organism
Pyrococcus sp. (strain NA2)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi298Zinc; catalyticUniRule annotation1
Metal bindingi350Zinc; catalyticUniRule annotation1
Metal bindingi474Zinc; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase, RNA-binding, tRNA-bindingUniRule annotation
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine--tRNA ligaseUniRule annotation (EC:6.1.1.3UniRule annotation)
Alternative name(s):
Threonyl-tRNA synthetaseUniRule annotation
Short name:
ThrRSUniRule annotation
Gene namesi
Name:thrSUniRule annotation
Ordered Locus Names:PNA2_1352Imported
OrganismiPyrococcus sp. (strain NA2)Imported
Taxonomic identifieri342949 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000008293 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi342949.PNA2_1352.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 505AA_TRNA_LIGASE_IIInterPro annotationAdd BLAST297

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00401. Archaea.
COG0441. LUCA.
KOiK01868.
OMAiDAHIFML.
OrthoDBiPOG093Z01GO.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00184. Thr_tRNA_synth. 1 hit.
InterProiView protein in InterPro
IPR002314. aa-tRNA-synt_IIb.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR036621. Anticodon-bd_dom_sf.
IPR002320. Thr-tRNA-ligase_IIa.
IPR015011. Threonyl-tRNA_syn_edit_dom_arc.
PANTHERiPTHR11451. PTHR11451. 1 hit.
PfamiView protein in Pfam
PF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF08915. tRNA-Thr_ED. 1 hit.
PRINTSiPR01047. TRNASYNTHTHR.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD016189. tRNA-Thr_ED_arc. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00418. thrS. 1 hit.
PROSITEiView protein in PROSITE
PS50862. AA_TRNA_LIGASE_II. 1 hit.

Sequencei

Sequence statusi: Complete.

F4HIG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMLLIHSDY IEYEVKDKAI KNPEPISDEE KKGRMDEVLV AFISVEKVDE
60 70 80 90 100
KNPDEVVDKA IEEIIKVAGQ VKAENIFVYP FAHLSSELAK PSTAQEVLRK
110 120 130 140 150
IYEGIKNRGY KVGKAPFGYY KAFKISCKGH PLAELSRTIV PEAAKEEEVP
160 170 180 190 200
EALKKEEKEL VSYWYILTPE GELIEVDKFD FTGYENLRKF ANYEISKSRI
210 220 230 240 250
AEKEPPHVKL MLEHELVDYE PGSDPGNLRY YPKGRLIKSL LEQYVTEKVI
260 270 280 290 300
EYGAMEVETP VMYDFEHPAL EKYLNRFPAR QYIVLSGDKR YFLRFAACFG
310 320 330 340 350
QFLISKDAVI SYKHLPLRMY ELTRYSFRRE KRGELSGLRR LRAFTMPDMH
360 370 380 390 400
TLAKDLEQAK EEFKKQFKLS MEVLEGVGLT PDDYEVAIRF TEDFWKENRD
410 420 430 440 450
FIIELVKLIG KPVLIEMWKQ RFFYFILKFE FNFVDNLDKA AALSTVQIDV
460 470 480 490 500
ENAERFGIKY YDENGEERYP LILHCSPSGA IERVMYAILE KQAKLMQQGK
510 520 530 540 550
KPMLPVWLSP IQVRVIPVSN DFLDYALYVA GKLEGAKIRV DVDDEDERLN
560 570 580 590 600
KKIRRAEKEW IPYIVVVGAK EKETGTIMVR RREDGKQYET RIEELIREIK
610 620
EKTEGFPYKP RPLPLLLSKR PKFRG
Length:625
Mass (Da):73,152
Last modified:June 28, 2011 - v1
Checksum:i39922D81D2C77B52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002670 Genomic DNA. Translation: AEC52266.1.
RefSeqiWP_013748816.1. NC_015474.1.

Genome annotation databases

EnsemblBacteriaiAEC52266; AEC52266; PNA2_1352.
GeneIDi10554835.
KEGGipyn:PNA2_1352.
PATRICifig|342949.8.peg.1356.

Similar proteinsi

Entry informationi

Entry nameiF4HIG6_PYRSN
AccessioniPrimary (citable) accession number: F4HIG6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 22, 2017
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteomeImported