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Protein

Threonine--tRNA ligase

Gene

thrS

Organism
Pyrococcus sp. (strain NA2)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi298Zinc; catalyticUniRule annotation1
Metal bindingi350Zinc; catalyticUniRule annotation1
Metal bindingi474Zinc; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase, RNA-binding, tRNA-bindingUniRule annotation
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciPSP342949:G1GX4-1402-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine--tRNA ligaseUniRule annotation (EC:6.1.1.3UniRule annotation)
Alternative name(s):
Threonyl-tRNA synthetaseUniRule annotation
Short name:
ThrRSUniRule annotation
Gene namesi
Name:thrSUniRule annotation
Ordered Locus Names:PNA2_1352Imported
OrganismiPyrococcus sp. (strain NA2)Imported
Taxonomic identifieri342949 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000008293 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi342949.PNA2_1352

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 505AA_TRNA_LIGASE_IIInterPro annotationAdd BLAST297

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili539 – 559Sequence analysisAdd BLAST21
Coiled coili585 – 605Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiarCOG00401 Archaea
COG0441 LUCA
KOiK01868
OMAiDAHIFML
OrthoDBiPOG093Z01GO

Family and domain databases

Gene3Di3.40.50.800, 1 hit
3.50.80.10, 1 hit
HAMAPiMF_00184 Thr_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR002314 aa-tRNA-synt_IIb
IPR006195 aa-tRNA-synth_II
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR023509 DTD-like_sf
IPR002320 Thr-tRNA-ligase_IIa
IPR015011 Threonyl-tRNA_syn_edit_dom_arc
PANTHERiPTHR11451 PTHR11451, 1 hit
PfamiView protein in Pfam
PF03129 HGTP_anticodon, 1 hit
PF00587 tRNA-synt_2b, 1 hit
PF08915 tRNA-Thr_ED, 1 hit
PRINTSiPR01047 TRNASYNTHTHR
ProDomiView protein in ProDom or Entries sharing at least one domain
PD016189 tRNA-Thr_ED_arc, 1 hit
TIGRFAMsiTIGR00418 thrS, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

F4HIG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMLLIHSDY IEYEVKDKAI KNPEPISDEE KKGRMDEVLV AFISVEKVDE
60 70 80 90 100
KNPDEVVDKA IEEIIKVAGQ VKAENIFVYP FAHLSSELAK PSTAQEVLRK
110 120 130 140 150
IYEGIKNRGY KVGKAPFGYY KAFKISCKGH PLAELSRTIV PEAAKEEEVP
160 170 180 190 200
EALKKEEKEL VSYWYILTPE GELIEVDKFD FTGYENLRKF ANYEISKSRI
210 220 230 240 250
AEKEPPHVKL MLEHELVDYE PGSDPGNLRY YPKGRLIKSL LEQYVTEKVI
260 270 280 290 300
EYGAMEVETP VMYDFEHPAL EKYLNRFPAR QYIVLSGDKR YFLRFAACFG
310 320 330 340 350
QFLISKDAVI SYKHLPLRMY ELTRYSFRRE KRGELSGLRR LRAFTMPDMH
360 370 380 390 400
TLAKDLEQAK EEFKKQFKLS MEVLEGVGLT PDDYEVAIRF TEDFWKENRD
410 420 430 440 450
FIIELVKLIG KPVLIEMWKQ RFFYFILKFE FNFVDNLDKA AALSTVQIDV
460 470 480 490 500
ENAERFGIKY YDENGEERYP LILHCSPSGA IERVMYAILE KQAKLMQQGK
510 520 530 540 550
KPMLPVWLSP IQVRVIPVSN DFLDYALYVA GKLEGAKIRV DVDDEDERLN
560 570 580 590 600
KKIRRAEKEW IPYIVVVGAK EKETGTIMVR RREDGKQYET RIEELIREIK
610 620
EKTEGFPYKP RPLPLLLSKR PKFRG
Length:625
Mass (Da):73,152
Last modified:June 28, 2011 - v1
Checksum:i39922D81D2C77B52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002670 Genomic DNA Translation: AEC52266.1
RefSeqiWP_013748816.1, NC_015474.1

Genome annotation databases

EnsemblBacteriaiAEC52266; AEC52266; PNA2_1352
GeneIDi10554835
KEGGipyn:PNA2_1352
PATRICifig|342949.8.peg.1356

Similar proteinsi

Entry informationi

Entry nameiF4HIG6_PYRSN
AccessioniPrimary (citable) accession number: F4HIG6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: February 28, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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