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F4GYB0

- F4GYB0_CELFA

UniProt

F4GYB0 - F4GYB0_CELFA

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Protein

Probable DNA ligase

Gene
lig, Celf_1767
Organism
Cellulomonas fimi (strain ATCC 484 / DSM 20113 / JCM 1341 / NBRC 15513 / NCIMB 8980 / NCTC 7547)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei215 – 2151ATP By similarityUniRule annotation
Active sitei217 – 2171N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei222 – 2221ATP By similarityUniRule annotation
Binding sitei237 – 2371ATP By similarityUniRule annotation
Binding sitei266 – 2661ATP By similarityUniRule annotation
Binding sitei304 – 3041ATP By similarityUniRule annotation
Binding sitei375 – 3751ATP By similarityUniRule annotation
Binding sitei381 – 3811ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciCFIM590998:GJFK-1788-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Celf_1767Imported
OrganismiCellulomonas fimi (strain ATCC 484 / DSM 20113 / JCM 1341 / NBRC 15513 / NCIMB 8980 / NCTC 7547)Imported
Taxonomic identifieri590998 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeCellulomonadaceaeCellulomonas
ProteomesiUP000008460: Chromosome

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01971.
OMAiVPIVIPY.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F4GYB0-1 [UniParc]FASTAAdd to Basket

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MLLADVAATS AAVAATRSRL AKRALLVDVL RRAEPEDVPV VARYLAGELR    50
QRRTGLGWRS LASLPGPAAG PSLTVAAVDA AFAHMAQLEG PGSATERSRL 100
AAELFAAATG PEQALLRGLV SGELRQGALD ALLLDALAEA AGVPPDAVRR 150
AAMLAGATEP VAVAALGAAD PQAALEALAA FTLTVGRPVR PMLAQSAPDV 200
ATAVAGLGGG PVVVDTKLDG IRIQVHRTAD DVRVYTRSLD DITARVPEIV 250
EAVRAVPAST LVLDGEALVV DDTGRPVPFQ DTAARSATKD ADVAAAVRLT 300
PFFFDCLHVD GRDLLDSPLT ERLAVLDATV GPAAVTRLVT ADPDAAQDWF 350
ARVVAAGQEG VVVKAADAPY EAGRRGAAWV KVKPRHTLDL VVLAVERGSG 400
RRSGWLSNIH LGARDGHGGF VMLGKTFKGM TDEMLAQQTE RFRELEVSDD 450
GWTVTVRPEQ VVEIAFDGVQ RSTRYPGGVA LRFARVVRYR DDKSAAQADT 500
IDAVRALHAP 510
Length:510
Mass (Da):53,499
Last modified:June 28, 2011 - v1
Checksum:i184E15B1AE0A3AA8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002666 Genomic DNA. Translation: AEE45899.1.
RefSeqiYP_004453286.1. NC_015514.1.

Genome annotation databases

EnsemblBacteriaiAEE45899; AEE45899; Celf_1767.
GeneIDi10592548.
KEGGicfi:Celf_1767.
PATRICi54614460. VBICelFim18861_1770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002666 Genomic DNA. Translation: AEE45899.1 .
RefSeqi YP_004453286.1. NC_015514.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEE45899 ; AEE45899 ; Celf_1767 .
GeneIDi 10592548.
KEGGi cfi:Celf_1767.
PATRICi 54614460. VBICelFim18861_1770.

Phylogenomic databases

KOi K01971.
OMAi VPIVIPY.

Enzyme and pathway databases

BioCyci CFIM590998:GJFK-1788-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Cellulomonas fimi ATCC 484."
    US DOE Joint Genome Institute
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Mead D., Brumm P., Woyke T.
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 484 / DSM 20113 / JCM 1341 / NBRC 15513 / NCIMB 8980 / NCTC 7547.

Entry informationi

Entry nameiF4GYB0_CELFA
AccessioniPrimary (citable) accession number: F4GYB0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: June 11, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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