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F4GUQ7

- F4GUQ7_PUSST

UniProt

F4GUQ7 - F4GUQ7_PUSST

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Protein

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Gene

metE

Organism
Pusillimonas sp. (strain T7-7)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.UniRule annotationSAAS annotation

Catalytic activityi

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.UniRule annotationSAAS annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi652 – 6521ZincUniRule annotation
Metal bindingi654 – 6541ZincUniRule annotation
Metal bindingi737 – 7371ZincUniRule annotation

GO - Molecular functioni

  1. 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. methionine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPSP1007105:GJAF-1371-MONOMER.
UniPathwayiUPA00051; UER00082.

Names & Taxonomyi

Protein namesi
Recommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseUniRule annotation (EC:2.1.1.14UniRule annotation)
Alternative name(s):
Cobalamin-independent methionine synthaseUniRule annotation
Methionine synthase, vitamin-B12 independent isozymeUniRule annotation
Gene namesi
Name:metEUniRule annotation
Ordered Locus Names:PT7_1349Imported
OrganismiPusillimonas sp. (strain T7-7)Imported
Taxonomic identifieri1007105 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaePusillimonas
ProteomesiUP000008737: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the vitamin-B12 independent methionine synthase family.UniRule annotation

Keywords - Domaini

RepeatUniRule annotation

Phylogenomic databases

KOiK00549.
OMAiFKANPAH.

Family and domain databases

HAMAPiMF_00172. Meth_synth.
InterProiIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Met_Synth_C/arc.
[Graphical view]
PfamiPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsiTIGR01371. met_syn_B12ind. 1 hit.

Sequencei

Sequence statusi: Complete.

F4GUQ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTITHNLGFP RIGVRRELKS SLEAYWAGKQ TLPELEATGR ELRARHWRLQ
60 70 80 90 100
AKSGLQFVPV GDFAWYDHIL EWTTLLGAVP ARFGQPSDED VGLDTLFRMA
110 120 130 140 150
RGRAPSGSPA AACEMTKWFD TNYHYIVPEL VPEQSYRIAR SYLFDQIREA
160 170 180 190 200
QSLGHKAKPV IPGPLTWLWL GKGDAFAQGA SDTAKLTLLD NLVPVYVQAL
210 220 230 240 250
EQIQNLGVEW VQIDEPILGL DLPDAWQQAF QPVYETLAKG GPRVLLATYF
260 270 280 290 300
EDLKENVQVL KGLPVDGVHV DLVRAPDQLA RVAAVLDDRQ VLSAGLIDGR
310 320 330 340 350
NVWRSDLDKA GDQIRQVAQQ RGDRLWLAPS CSLLHVPVDL DAERDLDAEL
360 370 380 390 400
RSWLSFATQK LDELNVLASS LANTVDADTQ EALVQQRVAL INRKNSSRIH
410 420 430 440 450
NPAVQQRLKA SVSVTRDRAP FQQRIASQQK KLGLPSYPTT TIGSFPQTSE
460 470 480 490 500
IRLARRDWKQ GALSDTAYEK AMRAEIEHVI RFQEKIGLDV LVHGEPERND
510 520 530 540 550
MVEYFGELLG GFAFTQNGWV QSYGSRCVKP PIIFGDVVRP AAMTVAWSAY
560 570 580 590 600
AQSLTEKPVK GMLTGPVTIL QWSFVRDDQP RATTCQQLAL ALRDEVTDLE
610 620 630 640 650
AAGITVIQID EPAFREGLPL RRADWRVYLD WAVDCFRLST GGVQDDTQIH
660 670 680 690 700
THMCYSEFND IIESIAAMDA DVITIETSRS NMELLGAFED FHYPNDIGPG
710 720 730 740 750
VYDIHSPNVP QLEWMVDLMK KASGRLPAER LWVNPDCGLK TRGWPETEAA
760
LLAMVKAAET LRYT
Length:764
Mass (Da):85,584
Last modified:June 28, 2011 - v1
Checksum:i3F43BC18C6AFB4E1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002663 Genomic DNA. Translation: AEC19889.1.
RefSeqiWP_013742425.1. NC_015458.1.
YP_004416513.1. NC_015458.1.

Genome annotation databases

EnsemblBacteriaiAEC19889; AEC19889; PT7_1349.
GeneIDi10606267.
KEGGiput:PT7_1349.
PATRICi54556965. VBIPusSp189076_1331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002663 Genomic DNA. Translation: AEC19889.1 .
RefSeqi WP_013742425.1. NC_015458.1.
YP_004416513.1. NC_015458.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEC19889 ; AEC19889 ; PT7_1349 .
GeneIDi 10606267.
KEGGi put:PT7_1349.
PATRICi 54556965. VBIPusSp189076_1331.

Phylogenomic databases

KOi K00549.
OMAi FKANPAH.

Enzyme and pathway databases

UniPathwayi UPA00051 ; UER00082 .
BioCyci PSP1007105:GJAF-1371-MONOMER.

Family and domain databases

HAMAPi MF_00172. Meth_synth.
InterProi IPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Met_Synth_C/arc.
[Graphical view ]
Pfami PF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsi TIGR01371. met_syn_B12ind. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Pusillimonas sp. T7-7, a cold-tolerant diesel oil-degrading bacterium isolated from the Bohai Sea in China."
    Cao B., Ma T., Ren Y., Ren Y., Li G., Li P., Guo X., Ding P., Feng L.
    J. Bacteriol. 193:4021-4022(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: T7-7Imported.
  2. "Genome Announcement Complete Genome Sequence of Pusillimonas sp. T7-7, a novel species isolated from the Bohai Sea, China."
    Cao B., Ma T., Li P., Jiang L., Li Y., Guo X., Feng L.
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: T7-7.

Entry informationi

Entry nameiF4GUQ7_PUSST
AccessioniPrimary (citable) accession number: F4GUQ7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: October 29, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3