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F4GUQ7

- F4GUQ7_PUSST

UniProt

F4GUQ7 - F4GUQ7_PUSST

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Protein
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
Gene
metE, PT7_1349
Organism
Pusillimonas sp. (strain T7-7)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.UniRule annotationSAAS annotations

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi652 – 6521Zinc By similarityUniRule annotation
Metal bindingi654 – 6541Zinc By similarityUniRule annotation
Metal bindingi737 – 7371Zinc By similarityUniRule annotation

GO - Molecular functioni

  1. 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. methionine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

Metal-bindingUniRule annotationSAAS annotations, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciPSP1007105:GJAF-1371-MONOMER.
UniPathwayiUPA00051; UER00082.

Names & Taxonomyi

Protein namesi
Recommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseUniRule annotation (EC:2.1.1.14UniRule annotation)
Alternative name(s):
Cobalamin-independent methionine synthase
Methionine synthase, vitamin-B12 independent isozyme
Gene namesi
Name:metEUniRule annotation
Ordered Locus Names:PT7_1349Imported
OrganismiPusillimonas sp. (strain T7-7)Imported
Taxonomic identifieri1007105 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaePusillimonas
ProteomesiUP000008737: Chromosome

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

RepeatUniRule annotation

Phylogenomic databases

KOiK00549.
OMAiFKANPAH.

Family and domain databases

HAMAPiMF_00172. Meth_synth.
InterProiIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Met_Synth_C/arc.
[Graphical view]
PfamiPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsiTIGR01371. met_syn_B12ind. 1 hit.

Sequencei

Sequence statusi: Complete.

F4GUQ7-1 [UniParc]FASTAAdd to Basket

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MTITHNLGFP RIGVRRELKS SLEAYWAGKQ TLPELEATGR ELRARHWRLQ    50
AKSGLQFVPV GDFAWYDHIL EWTTLLGAVP ARFGQPSDED VGLDTLFRMA 100
RGRAPSGSPA AACEMTKWFD TNYHYIVPEL VPEQSYRIAR SYLFDQIREA 150
QSLGHKAKPV IPGPLTWLWL GKGDAFAQGA SDTAKLTLLD NLVPVYVQAL 200
EQIQNLGVEW VQIDEPILGL DLPDAWQQAF QPVYETLAKG GPRVLLATYF 250
EDLKENVQVL KGLPVDGVHV DLVRAPDQLA RVAAVLDDRQ VLSAGLIDGR 300
NVWRSDLDKA GDQIRQVAQQ RGDRLWLAPS CSLLHVPVDL DAERDLDAEL 350
RSWLSFATQK LDELNVLASS LANTVDADTQ EALVQQRVAL INRKNSSRIH 400
NPAVQQRLKA SVSVTRDRAP FQQRIASQQK KLGLPSYPTT TIGSFPQTSE 450
IRLARRDWKQ GALSDTAYEK AMRAEIEHVI RFQEKIGLDV LVHGEPERND 500
MVEYFGELLG GFAFTQNGWV QSYGSRCVKP PIIFGDVVRP AAMTVAWSAY 550
AQSLTEKPVK GMLTGPVTIL QWSFVRDDQP RATTCQQLAL ALRDEVTDLE 600
AAGITVIQID EPAFREGLPL RRADWRVYLD WAVDCFRLST GGVQDDTQIH 650
THMCYSEFND IIESIAAMDA DVITIETSRS NMELLGAFED FHYPNDIGPG 700
VYDIHSPNVP QLEWMVDLMK KASGRLPAER LWVNPDCGLK TRGWPETEAA 750
LLAMVKAAET LRYT 764
Length:764
Mass (Da):85,584
Last modified:June 28, 2011 - v1
Checksum:i3F43BC18C6AFB4E1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002663 Genomic DNA. Translation: AEC19889.1.
RefSeqiWP_013742425.1. NC_015458.1.
YP_004416513.1. NC_015458.1.

Genome annotation databases

EnsemblBacteriaiAEC19889; AEC19889; PT7_1349.
GeneIDi10606267.
KEGGiput:PT7_1349.
PATRICi54556965. VBIPusSp189076_1331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002663 Genomic DNA. Translation: AEC19889.1 .
RefSeqi WP_013742425.1. NC_015458.1.
YP_004416513.1. NC_015458.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEC19889 ; AEC19889 ; PT7_1349 .
GeneIDi 10606267.
KEGGi put:PT7_1349.
PATRICi 54556965. VBIPusSp189076_1331.

Phylogenomic databases

KOi K00549.
OMAi FKANPAH.

Enzyme and pathway databases

UniPathwayi UPA00051 ; UER00082 .
BioCyci PSP1007105:GJAF-1371-MONOMER.

Family and domain databases

HAMAPi MF_00172. Meth_synth.
InterProi IPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Met_Synth_C/arc.
[Graphical view ]
Pfami PF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsi TIGR01371. met_syn_B12ind. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Pusillimonas sp. T7-7, a cold-tolerant diesel oil-degrading bacterium isolated from the Bohai Sea in China."
    Cao B., Ma T., Ren Y., Ren Y., Li G., Li P., Guo X., Ding P., Feng L.
    J. Bacteriol. 193:4021-4022(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: T7-7Imported.
  2. "Genome Announcement Complete Genome Sequence of Pusillimonas sp. T7-7, a novel species isolated from the Bohai Sea, China."
    Cao B., Ma T., Li P., Jiang L., Li Y., Guo X., Feng L.
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: T7-7.

Entry informationi

Entry nameiF4GUQ7_PUSST
AccessioniPrimary (citable) accession number: F4GUQ7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 3, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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