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F4GUQ7

- F4GUQ7_PUSST

UniProt

F4GUQ7 - F4GUQ7_PUSST

Protein

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Gene

metE

Organism
Pusillimonas sp. (strain T7-7)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.UniRule annotationSAAS annotation

    Catalytic activityi

    5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi652 – 6521ZincUniRule annotation
    Metal bindingi654 – 6541ZincUniRule annotation
    Metal bindingi737 – 7371ZincUniRule annotation

    GO - Molecular functioni

    1. 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. methionine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Methionine biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciPSP1007105:GJAF-1371-MONOMER.
    UniPathwayiUPA00051; UER00082.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseUniRule annotation (EC:2.1.1.14UniRule annotation)
    Alternative name(s):
    Cobalamin-independent methionine synthaseUniRule annotation
    Methionine synthase, vitamin-B12 independent isozymeUniRule annotation
    Gene namesi
    Name:metEUniRule annotation
    Ordered Locus Names:PT7_1349Imported
    OrganismiPusillimonas sp. (strain T7-7)Imported
    Taxonomic identifieri1007105 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaePusillimonas
    ProteomesiUP000008737: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the vitamin-B12 independent methionine synthase family.UniRule annotation

    Keywords - Domaini

    RepeatUniRule annotation

    Phylogenomic databases

    KOiK00549.
    OMAiFKANPAH.

    Family and domain databases

    HAMAPiMF_00172. Meth_synth.
    InterProiIPR013215. Cbl-indep_Met_Synth_N.
    IPR006276. Cobalamin-indep_Met_synthase.
    IPR002629. Met_Synth_C/arc.
    [Graphical view]
    PfamiPF08267. Meth_synt_1. 1 hit.
    PF01717. Meth_synt_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000382. MeTrfase_B12_ind. 1 hit.
    TIGRFAMsiTIGR01371. met_syn_B12ind. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F4GUQ7-1 [UniParc]FASTAAdd to Basket

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    MTITHNLGFP RIGVRRELKS SLEAYWAGKQ TLPELEATGR ELRARHWRLQ    50
    AKSGLQFVPV GDFAWYDHIL EWTTLLGAVP ARFGQPSDED VGLDTLFRMA 100
    RGRAPSGSPA AACEMTKWFD TNYHYIVPEL VPEQSYRIAR SYLFDQIREA 150
    QSLGHKAKPV IPGPLTWLWL GKGDAFAQGA SDTAKLTLLD NLVPVYVQAL 200
    EQIQNLGVEW VQIDEPILGL DLPDAWQQAF QPVYETLAKG GPRVLLATYF 250
    EDLKENVQVL KGLPVDGVHV DLVRAPDQLA RVAAVLDDRQ VLSAGLIDGR 300
    NVWRSDLDKA GDQIRQVAQQ RGDRLWLAPS CSLLHVPVDL DAERDLDAEL 350
    RSWLSFATQK LDELNVLASS LANTVDADTQ EALVQQRVAL INRKNSSRIH 400
    NPAVQQRLKA SVSVTRDRAP FQQRIASQQK KLGLPSYPTT TIGSFPQTSE 450
    IRLARRDWKQ GALSDTAYEK AMRAEIEHVI RFQEKIGLDV LVHGEPERND 500
    MVEYFGELLG GFAFTQNGWV QSYGSRCVKP PIIFGDVVRP AAMTVAWSAY 550
    AQSLTEKPVK GMLTGPVTIL QWSFVRDDQP RATTCQQLAL ALRDEVTDLE 600
    AAGITVIQID EPAFREGLPL RRADWRVYLD WAVDCFRLST GGVQDDTQIH 650
    THMCYSEFND IIESIAAMDA DVITIETSRS NMELLGAFED FHYPNDIGPG 700
    VYDIHSPNVP QLEWMVDLMK KASGRLPAER LWVNPDCGLK TRGWPETEAA 750
    LLAMVKAAET LRYT 764
    Length:764
    Mass (Da):85,584
    Last modified:June 28, 2011 - v1
    Checksum:i3F43BC18C6AFB4E1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002663 Genomic DNA. Translation: AEC19889.1.
    RefSeqiWP_013742425.1. NC_015458.1.
    YP_004416513.1. NC_015458.1.

    Genome annotation databases

    EnsemblBacteriaiAEC19889; AEC19889; PT7_1349.
    GeneIDi10606267.
    KEGGiput:PT7_1349.
    PATRICi54556965. VBIPusSp189076_1331.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002663 Genomic DNA. Translation: AEC19889.1 .
    RefSeqi WP_013742425.1. NC_015458.1.
    YP_004416513.1. NC_015458.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEC19889 ; AEC19889 ; PT7_1349 .
    GeneIDi 10606267.
    KEGGi put:PT7_1349.
    PATRICi 54556965. VBIPusSp189076_1331.

    Phylogenomic databases

    KOi K00549.
    OMAi FKANPAH.

    Enzyme and pathway databases

    UniPathwayi UPA00051 ; UER00082 .
    BioCyci PSP1007105:GJAF-1371-MONOMER.

    Family and domain databases

    HAMAPi MF_00172. Meth_synth.
    InterProi IPR013215. Cbl-indep_Met_Synth_N.
    IPR006276. Cobalamin-indep_Met_synthase.
    IPR002629. Met_Synth_C/arc.
    [Graphical view ]
    Pfami PF08267. Meth_synt_1. 1 hit.
    PF01717. Meth_synt_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000382. MeTrfase_B12_ind. 1 hit.
    TIGRFAMsi TIGR01371. met_syn_B12ind. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Pusillimonas sp. T7-7, a cold-tolerant diesel oil-degrading bacterium isolated from the Bohai Sea in China."
      Cao B., Ma T., Ren Y., Ren Y., Li G., Li P., Guo X., Ding P., Feng L.
      J. Bacteriol. 193:4021-4022(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: T7-7Imported.
    2. "Genome Announcement Complete Genome Sequence of Pusillimonas sp. T7-7, a novel species isolated from the Bohai Sea, China."
      Cao B., Ma T., Li P., Jiang L., Li Y., Guo X., Feng L.
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: T7-7.

    Entry informationi

    Entry nameiF4GUQ7_PUSST
    AccessioniPrimary (citable) accession number: F4GUQ7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3