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Protein

Alanine racemase

Gene

PT7_3361

Organism
Pusillimonas sp. (strain T7-7)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei61 – 611Proton acceptor; specific for D-alanineUniRule annotation
Active sitei283 – 2831Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei331 – 3311Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPSP1007105:GJAF-3411-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:PT7_3361Imported
OrganismiPusillimonas sp. (strain T7-7)Imported
Taxonomic identifieri1007105 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaePusillimonas
ProteomesiUP000008737: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF4GQK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

F4GQK3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSAIPVQTP IQARSKSGHA CHNSPLALID HTAIRHNLNR LRQLLAYPKT
60 70 80 90 100
LPTPLIWAVA KADAYGHTLE HAYAGLCEAD GLAVLTLDEA RHCRSLGWTG
110 120 130 140 150
PILAMSAQIT QAALEDPILY PLHLIIDHQE QLAAIQSLRP PFSPHVWLRY
160 170 180 190 200
RGRLNHAGFD QAGYKSAYAS LQSGLRDGRL AELGHLQHYA TAEEAEPMLA
210 220 230 240 250
ERQAFQLLIE GLPGPVCTDN SAALLSDHSG AALTSWVRSG IALYGISPLA
260 270 280 290 300
GLNGKDLGLR PAMVLQAPLY GFQTLQAGDS LGYGSTFLAS RKTRVGLVRC
310 320 330 340 350
GYAHGYPRSI PEGCEVMVTG RMATIIGRVS MDTLTIDLTD HPDAGYGTVV
360 370 380
TLWGTPELPI EVVAAQANTI PAQLCTALTE RVPRQSVS
Length:388
Mass (Da):41,750
Last modified:June 28, 2011 - v1
Checksum:iD4603A8D9D8EBA3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002663 Genomic DNA. Translation: AEC21901.1.
RefSeqiWP_013744420.1. NC_015458.1.
YP_004418525.1. NC_015458.1.

Genome annotation databases

EnsemblBacteriaiAEC21901; AEC21901; PT7_3361.
GeneIDi10604042.
KEGGiput:PT7_3361.
PATRICi54560998. VBIPusSp189076_3314.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002663 Genomic DNA. Translation: AEC21901.1.
RefSeqiWP_013744420.1. NC_015458.1.
YP_004418525.1. NC_015458.1.

3D structure databases

ProteinModelPortaliF4GQK3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEC21901; AEC21901; PT7_3361.
GeneIDi10604042.
KEGGiput:PT7_3361.
PATRICi54560998. VBIPusSp189076_3314.

Phylogenomic databases

KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciPSP1007105:GJAF-3411-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Pusillimonas sp. T7-7, a cold-tolerant diesel oil-degrading bacterium isolated from the Bohai Sea in China."
    Cao B., Ma T., Ren Y., Ren Y., Li G., Li P., Guo X., Ding P., Feng L.
    J. Bacteriol. 193:4021-4022(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: T7-7Imported.
  2. "Genome Announcement Complete Genome Sequence of Pusillimonas sp. T7-7, a novel species isolated from the Bohai Sea, China."
    Cao B., Ma T., Li P., Jiang L., Li Y., Guo X., Feng L.
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: T7-7.

Entry informationi

Entry nameiF4GQK3_PUSST
AccessioniPrimary (citable) accession number: F4GQK3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: February 4, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.