ID   F4GK86_PARC1            Unreviewed;       435 AA.
AC   F4GK86;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   SubName: Full=Hexokinase {ECO:0000313|EMBL:AEC02282.1};
DE            EC=2.7.1.1 {ECO:0000313|EMBL:AEC02282.1};
GN   OrderedLocusNames=Spico_1061 {ECO:0000313|EMBL:AEC02282.1};
OS   Parasphaerochaeta coccoides (strain ATCC BAA-1237 / DSM 17374 / SPN1)
OS   (Sphaerochaeta coccoides).
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Sphaerochaetaceae;
OC   Parasphaerochaeta.
OX   NCBI_TaxID=760011 {ECO:0000313|EMBL:AEC02282.1, ECO:0000313|Proteomes:UP000007939};
RN   [1] {ECO:0000313|Proteomes:UP000007939}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1237 / DSM 17374 / SPN1
RC   {ECO:0000313|Proteomes:UP000007939};
RA   Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA   Peters L., Kyrpides N., Mavromatis K., Pagani I., Ivanova N.,
RA   Ovchinnikova G., Lu M., Detter J.C., Tapia R., Han C., Land M., Hauser L.,
RA   Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Spring S.,
RA   Schroeder M., Brambilla E., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Spirochaeta coccoides DSM 17374.";
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AEC02282.1, ECO:0000313|Proteomes:UP000007939}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1237 / DSM 17374 / SPN1
RC   {ECO:0000313|Proteomes:UP000007939};
RX   PubMed=22768363; DOI=10.4056/sigs.2796069;
RA   Abt B., Han C., Scheuner C., Lu M., Lapidus A., Nolan M., Lucas S.,
RA   Hammon N., Deshpande S., Cheng J.F., Tapia R., Goodwin L.A., Pitluck S.,
RA   Liolios K., Pagani I., Ivanova N., Mavromatis K., Mikhailova N.,
RA   Huntemann M., Pati A., Chen A., Palaniappan K., Land M., Hauser L.,
RA   Brambilla E.M., Rohde M., Spring S., Gronow S., Goker M., Woyke T.,
RA   Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA   Klenk H.P., Detter J.C.;
RT   "Complete genome sequence of the termite hindgut bacterium Spirochaeta
RT   coccoides type strain (SPN1(T)), reclassification in the genus
RT   Sphaerochaeta as Sphaerochaeta coccoides comb. nov. and emendations of the
RT   family Spirochaetaceae and the genus Sphaerochaeta.";
RL   Stand. Genomic Sci. 6:194-209(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+);
CC         Xref=Rhea:RHEA:16125, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:37721, ChEBI:CHEBI:61527, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001397};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16126;
CC         Evidence={ECO:0000256|ARBA:ARBA00001397};
CC   -!- PATHWAY: Carbohydrate degradation. {ECO:0000256|ARBA:ARBA00004921}.
CC   -!- PATHWAY: Carbohydrate metabolism. {ECO:0000256|ARBA:ARBA00005007}.
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|ARBA:ARBA00009225}.
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DR   EMBL; CP002659; AEC02282.1; -; Genomic_DNA.
DR   RefSeq; WP_013739677.1; NC_015436.1.
DR   AlphaFoldDB; F4GK86; -.
DR   STRING; 760011.Spico_1061; -.
DR   KEGG; scc:Spico_1061; -.
DR   eggNOG; COG5026; Bacteria.
DR   HOGENOM; CLU_014393_5_3_12; -.
DR   OrthoDB; 6383434at2; -.
DR   UniPathway; UPA00109; UER00180.
DR   Proteomes; UP000007939; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008865; F:fructokinase activity; IEA:RHEA.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.40.367.20; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; HEXOKINASE; 1.
DR   PANTHER; PTHR19443:SF16; HEXOKINASE TYPE 1-RELATED; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 1.
DR   PRINTS; PR00475; HEXOKINASE.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007939};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AEC02282.1}.
FT   DOMAIN          20..196
FT                   /note="Hexokinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00349"
FT   DOMAIN          209..432
FT                   /note="Hexokinase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03727"
SQ   SEQUENCE   435 AA;  47512 MW;  BFBD7A4016C7DF99 CRC64;
     MGDIGARTGK FLRKWKLTPE DVDMEVVVGK FLDEMEKGLT GETSSLHMIP TYVDDKVTIQ
     PGESVIVLDA GGTNFRTCVV TFGANMEPTI TDFQKTGMPG VKTEVSASEF FSVLADDVER
     IIDRSDRIGF CYSYAASIFP DHDGRTIVFS KEIKAPEVIG MPIGASLLAE LARRGHDVSR
     KRVSVINDTV ATLLATKAEA RSSHASGFIG FILGTGTNTA YIEDNSRITK LSNLEAGSQI
     INVESGGFNF SLGEMDRKFF ATTKDPDSYH FEKLISGAYL GAFSHQVILQ AIEEGIFSRG
     FADRFVRIAP LTTTTMSNYL EEPFNAAYAL VHVVGDNDDD AFALWRIIDS LIARAAKLTA
     VNLSATIMKA SPGKDPRRPV VINADGTTFY KTENLKRYTD FYLHSFLTER QGISTAMVRI
     EDSPVIGAAI AGLSL
//