ID   F4GIY4_PARC1            Unreviewed;       384 AA.
AC   F4GIY4;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   RecName: Full=thymidine kinase {ECO:0000256|ARBA:ARBA00012118};
DE            EC=2.7.1.21 {ECO:0000256|ARBA:ARBA00012118};
GN   OrderedLocusNames=Spico_0037 {ECO:0000313|EMBL:AEC01279.1};
OS   Parasphaerochaeta coccoides (strain ATCC BAA-1237 / DSM 17374 / SPN1)
OS   (Sphaerochaeta coccoides).
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Sphaerochaetaceae;
OC   Parasphaerochaeta.
OX   NCBI_TaxID=760011 {ECO:0000313|EMBL:AEC01279.1, ECO:0000313|Proteomes:UP000007939};
RN   [1] {ECO:0000313|Proteomes:UP000007939}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1237 / DSM 17374 / SPN1
RC   {ECO:0000313|Proteomes:UP000007939};
RA   Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA   Peters L., Kyrpides N., Mavromatis K., Pagani I., Ivanova N.,
RA   Ovchinnikova G., Lu M., Detter J.C., Tapia R., Han C., Land M., Hauser L.,
RA   Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Spring S.,
RA   Schroeder M., Brambilla E., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Spirochaeta coccoides DSM 17374.";
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AEC01279.1, ECO:0000313|Proteomes:UP000007939}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1237 / DSM 17374 / SPN1
RC   {ECO:0000313|Proteomes:UP000007939};
RX   PubMed=22768363; DOI=10.4056/sigs.2796069;
RA   Abt B., Han C., Scheuner C., Lu M., Lapidus A., Nolan M., Lucas S.,
RA   Hammon N., Deshpande S., Cheng J.F., Tapia R., Goodwin L.A., Pitluck S.,
RA   Liolios K., Pagani I., Ivanova N., Mavromatis K., Mikhailova N.,
RA   Huntemann M., Pati A., Chen A., Palaniappan K., Land M., Hauser L.,
RA   Brambilla E.M., Rohde M., Spring S., Gronow S., Goker M., Woyke T.,
RA   Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA   Klenk H.P., Detter J.C.;
RT   "Complete genome sequence of the termite hindgut bacterium Spirochaeta
RT   coccoides type strain (SPN1(T)), reclassification in the genus
RT   Sphaerochaeta as Sphaerochaeta coccoides comb. nov. and emendations of the
RT   family Spirochaetaceae and the genus Sphaerochaeta.";
RL   Stand. Genomic Sci. 6:194-209(2012).
CC   -!- SIMILARITY: Belongs to the thymidine kinase family.
CC       {ECO:0000256|ARBA:ARBA00007587}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP002659; AEC01279.1; -; Genomic_DNA.
DR   RefSeq; WP_013738675.1; NC_015436.1.
DR   AlphaFoldDB; F4GIY4; -.
DR   STRING; 760011.Spico_0037; -.
DR   KEGG; scc:Spico_0037; -.
DR   eggNOG; COG1435; Bacteria.
DR   HOGENOM; CLU_753704_0_0_12; -.
DR   OrthoDB; 9781579at2; -.
DR   Proteomes; UP000007939; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.60.20; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001267; Thymidine_kinase.
DR   Pfam; PF00265; TK; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA synthesis {ECO:0000256|ARBA:ARBA00022634};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AEC01279.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007939};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ   SEQUENCE   384 AA;  43855 MW;  5102AD4B25FA5412 CRC64;
     MPHTDRSLAN GDATDFLKSL GFPSVTVHET FTHFDFTSPG RRVLLIGPMG SGKTEFSARV
     WRDAAVAQKK SDVVRRLTAT GDVDRRKVFF IRSELDATRF SGYPDDAMAY RGGYIRCGEN
     IARIKDSFGL EKVIEDHPDI GTYIIDEASF FDERLVYVVR NHSMQRGVMF IFPTLILNFR
     RDIFNSTARL MLDMATDVIP LTAYCEHPDC MKSAFYTYRY YQVGDKECPA LYFDPLIIVG
     GDEHKVDSFQ PNYAARCDEH HYLPGKEYTF FHLKPMGMMA ARGEENPLRS ELGALKGNIG
     KSLLYRNLAE GTPDGLQREM FLNSLLPANI AEKALAYLFS EQNLVPEELL VRLVSELELD
     REYLQKVLED NRRPVVFDQQ LLFS
//