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F4GCB3

- F4GCB3_ALIDK

UniProt

F4GCB3 - F4GCB3_ALIDK

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Protein

Dihydroorotate dehydrogenase (quinone)

Gene

pyrD

Organism
Alicycliphilus denitrificans (strain DSM 14773 / CIP 107495 / K601)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.UniRule annotationSAAS annotation

Catalytic activityi

(S)-dihydroorotate + a quinone = orotate + a quinol.UniRule annotationSAAS annotation

Cofactori

Note: Binds 1 FMN per subunit.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei69 – 691SubstrateUniRule annotation
Binding sitei89 – 891FMN; via amide nitrogenUniRule annotation
Binding sitei147 – 1471FMNUniRule annotation
Binding sitei180 – 1801FMNUniRule annotation
Binding sitei180 – 1801SubstrateUniRule annotation
Active sitei183 – 1831NucleophileUniRule annotation
Binding sitei185 – 1851SubstrateUniRule annotation
Binding sitei225 – 2251FMNUniRule annotation
Binding sitei253 – 2531FMN; via carbonyl oxygenUniRule annotation
Binding sitei276 – 2761FMN; via amide nitrogenUniRule annotation
Binding sitei305 – 3051FMN; via amide nitrogenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 695FMNUniRule annotation
Nucleotide bindingi326 – 3272FMNUniRule annotation

GO - Molecular functioni

  1. dihydroorotate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Biological processi

Pyrimidine biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

Flavoprotein, FMNUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciADEN596154:GHU6-2439-MONOMER.
UniPathwayiUPA00070; UER00946.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroorotate dehydrogenase (quinone)UniRule annotation (EC:1.3.5.2UniRule annotation)
Alternative name(s):
DHOdehaseUniRule annotation
Dihydroorotate oxidaseUniRule annotation
Gene namesi
Name:pyrDUniRule annotation
Ordered Locus Names:Alide2_2408Imported
OrganismiAlicycliphilus denitrificans (strain DSM 14773 / CIP 107495 / K601)Imported
Taxonomic identifieri596154 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAlicycliphilus
ProteomesiUP000007938: Chromosome

Subcellular locationi

Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Subunit structurei

Monomer.UniRule annotationSAAS annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni114 – 1185Substrate bindingUniRule annotation
Regioni254 – 2552Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

KOiK00254.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00225. DHO_dh_type2.
InterProiIPR013785. Aldolase_TIM.
IPR012135. Dihydroorotate_DH_1_2.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
PfamiPF01180. DHO_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsiTIGR01036. pyrD_sub2. 1 hit.
PROSITEiPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F4GCB3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLLPYAFAR PFLFGMDAEA AHELTMDMLA RGQRTPLQWA WCNETVSDPV
60 70 80 90 100
QLAGLTFPNR VGLAAGLDKN ARCIDALAAM GFGFVEVGTV TPKAQPGNPK
110 120 130 140 150
PRMFRLPEAR ALINRLGFNN EGLDAFIANV RRSQVRAQGK PLLLGLNIGK
160 170 180 190 200
NAATPIEQAT GDYLACLEGV YPHADYVTVN ISSPNTQNLR ALQSDEALDA
210 220 230 240 250
LLGAIADHRE KLAAAQGRRV PIFVKIAPDL NEAQVAVIAA TLTRHGMDGV
260 270 280 290 300
VATNTTIARD AVQGLPHAGE AGGLSGAPVR EASNAVIRQL RAALGPAFPI
310 320 330 340
VGVGGVMSAE DAVGKIRAGA DVVQIYTGLI YEGPALVSRA ARAIRAMR
Length:348
Mass (Da):36,742
Last modified:June 28, 2011 - v1
Checksum:i843DD28148E780DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002657 Genomic DNA. Translation: AEB84772.1.
RefSeqiWP_013519048.1. NC_015422.1.
YP_004388288.1. NC_015422.1.

Genome annotation databases

EnsemblBacteriaiAEB84772; AEB84772; Alide2_2408.
GeneIDi10483455.
KEGGiadk:Alide2_2408.
PATRICi54527494. VBIAliDen79014_2432.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002657 Genomic DNA. Translation: AEB84772.1 .
RefSeqi WP_013519048.1. NC_015422.1.
YP_004388288.1. NC_015422.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEB84772 ; AEB84772 ; Alide2_2408 .
GeneIDi 10483455.
KEGGi adk:Alide2_2408.
PATRICi 54527494. VBIAliDen79014_2432.

Phylogenomic databases

KOi K00254.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00946 .
BioCyci ADEN596154:GHU6-2439-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00225. DHO_dh_type2.
InterProi IPR013785. Aldolase_TIM.
IPR012135. Dihydroorotate_DH_1_2.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view ]
Pfami PF01180. DHO_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsi TIGR01036. pyrD_sub2. 1 hit.
PROSITEi PS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Alicycliphilus denitrificans K601."
    US DOE Joint Genome Institute
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Zeytun A., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mikhailova N., Pagani I., Oosterkamp M.
    , Pieper D., van Berkel W., Langenhoff A., Smidt H., Stams A., Woyke T.
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14773 / CIP 107495 / K601Imported.

Entry informationi

Entry nameiF4GCB3_ALIDK
AccessioniPrimary (citable) accession number: F4GCB3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 26, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3