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F4GCB3

- F4GCB3_ALIDK

UniProt

F4GCB3 - F4GCB3_ALIDK

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Protein
Dihydroorotate dehydrogenase (quinone)
Gene
pyrD, Alide2_2408
Organism
Alicycliphilus denitrificans (strain DSM 14773 / CIP 107495 / K601)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor By similarity.UniRule annotationSAAS annotations

Catalytic activityi

(S)-dihydroorotate + a quinone = orotate + a quinol.UniRule annotationSAAS annotations

Cofactori

Binds 1 FMN per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei69 – 691Substrate By similarityUniRule annotation
Binding sitei89 – 891FMN; via amide nitrogen By similarityUniRule annotation
Binding sitei147 – 1471FMN By similarityUniRule annotation
Binding sitei180 – 1801FMN By similarityUniRule annotation
Binding sitei180 – 1801Substrate By similarityUniRule annotation
Active sitei183 – 1831Nucleophile By similarityUniRule annotation
Binding sitei185 – 1851Substrate By similarityUniRule annotation
Binding sitei225 – 2251FMN By similarityUniRule annotation
Binding sitei253 – 2531FMN; via carbonyl oxygen By similarityUniRule annotation
Binding sitei276 – 2761FMN; via amide nitrogen By similarityUniRule annotation
Binding sitei305 – 3051FMN; via amide nitrogen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 695FMN By similarityUniRule annotation
Nucleotide bindingi326 – 3272FMN By similarityUniRule annotation

GO - Molecular functioni

  1. dihydroorotate oxidase activity Source: InterPro

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Pyrimidine biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

Flavoprotein, FMNUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciADEN596154:GHU6-2439-MONOMER.
UniPathwayiUPA00070; UER00946.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroorotate dehydrogenase (quinone)UniRule annotation (EC:1.3.5.2UniRule annotation)
Alternative name(s):
DHOdehase
Dihydroorotate oxidase
Gene namesi
Name:pyrDUniRule annotation
Ordered Locus Names:Alide2_2408Imported
OrganismiAlicycliphilus denitrificans (strain DSM 14773 / CIP 107495 / K601)Imported
Taxonomic identifieri596154 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAlicycliphilus
ProteomesiUP000007938: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni114 – 1185Substrate binding By similarityUniRule annotation
Regioni254 – 2552Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00254.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00225. DHO_dh_type2.
InterProiIPR013785. Aldolase_TIM.
IPR012135. Dihydroorotate_DH_1_2.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
PfamiPF01180. DHO_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsiTIGR01036. pyrD_sub2. 1 hit.
PROSITEiPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F4GCB3-1 [UniParc]FASTAAdd to Basket

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MSLLPYAFAR PFLFGMDAEA AHELTMDMLA RGQRTPLQWA WCNETVSDPV    50
QLAGLTFPNR VGLAAGLDKN ARCIDALAAM GFGFVEVGTV TPKAQPGNPK 100
PRMFRLPEAR ALINRLGFNN EGLDAFIANV RRSQVRAQGK PLLLGLNIGK 150
NAATPIEQAT GDYLACLEGV YPHADYVTVN ISSPNTQNLR ALQSDEALDA 200
LLGAIADHRE KLAAAQGRRV PIFVKIAPDL NEAQVAVIAA TLTRHGMDGV 250
VATNTTIARD AVQGLPHAGE AGGLSGAPVR EASNAVIRQL RAALGPAFPI 300
VGVGGVMSAE DAVGKIRAGA DVVQIYTGLI YEGPALVSRA ARAIRAMR 348
Length:348
Mass (Da):36,742
Last modified:June 28, 2011 - v1
Checksum:i843DD28148E780DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002657 Genomic DNA. Translation: AEB84772.1.
RefSeqiWP_013519048.1. NC_015422.1.
YP_004388288.1. NC_015422.1.

Genome annotation databases

EnsemblBacteriaiAEB84772; AEB84772; Alide2_2408.
GeneIDi10483455.
KEGGiadk:Alide2_2408.
PATRICi54527494. VBIAliDen79014_2432.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002657 Genomic DNA. Translation: AEB84772.1 .
RefSeqi WP_013519048.1. NC_015422.1.
YP_004388288.1. NC_015422.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEB84772 ; AEB84772 ; Alide2_2408 .
GeneIDi 10483455.
KEGGi adk:Alide2_2408.
PATRICi 54527494. VBIAliDen79014_2432.

Phylogenomic databases

KOi K00254.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00946 .
BioCyci ADEN596154:GHU6-2439-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00225. DHO_dh_type2.
InterProi IPR013785. Aldolase_TIM.
IPR012135. Dihydroorotate_DH_1_2.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view ]
Pfami PF01180. DHO_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsi TIGR01036. pyrD_sub2. 1 hit.
PROSITEi PS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Alicycliphilus denitrificans K601."
    US DOE Joint Genome Institute
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Zeytun A., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mikhailova N., Pagani I., Oosterkamp M.
    , Pieper D., van Berkel W., Langenhoff A., Smidt H., Stams A., Woyke T.
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14773 / CIP 107495 / K601.

Entry informationi

Entry nameiF4GCB3_ALIDK
AccessioniPrimary (citable) accession number: F4GCB3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 3, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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