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F4GCB3

- F4GCB3_ALIDK

UniProt

F4GCB3 - F4GCB3_ALIDK

Protein

Dihydroorotate dehydrogenase (quinone)

Gene

pyrD

Organism
Alicycliphilus denitrificans (strain DSM 14773 / CIP 107495 / K601)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.UniRule annotationSAAS annotation

    Catalytic activityi

    (S)-dihydroorotate + a quinone = orotate + a quinol.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 FMN per subunit.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei69 – 691SubstrateUniRule annotation
    Binding sitei89 – 891FMN; via amide nitrogenUniRule annotation
    Binding sitei147 – 1471FMNUniRule annotation
    Binding sitei180 – 1801FMNUniRule annotation
    Binding sitei180 – 1801SubstrateUniRule annotation
    Active sitei183 – 1831NucleophileUniRule annotation
    Binding sitei185 – 1851SubstrateUniRule annotation
    Binding sitei225 – 2251FMNUniRule annotation
    Binding sitei253 – 2531FMN; via carbonyl oxygenUniRule annotation
    Binding sitei276 – 2761FMN; via amide nitrogenUniRule annotation
    Binding sitei305 – 3051FMN; via amide nitrogenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 695FMNUniRule annotation
    Nucleotide bindingi326 – 3272FMNUniRule annotation

    GO - Molecular functioni

    1. dihydroorotate oxidase activity Source: InterPro

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Pyrimidine biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    Flavoprotein, FMNUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciADEN596154:GHU6-2439-MONOMER.
    UniPathwayiUPA00070; UER00946.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydroorotate dehydrogenase (quinone)UniRule annotation (EC:1.3.5.2UniRule annotation)
    Alternative name(s):
    DHOdehaseUniRule annotation
    Dihydroorotate oxidaseUniRule annotation
    Gene namesi
    Name:pyrDUniRule annotation
    Ordered Locus Names:Alide2_2408Imported
    OrganismiAlicycliphilus denitrificans (strain DSM 14773 / CIP 107495 / K601)Imported
    Taxonomic identifieri596154 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAlicycliphilus
    ProteomesiUP000007938: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membraneUniRule annotation, Membrane

    Interactioni

    Subunit structurei

    Monomer.UniRule annotationSAAS annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni114 – 1185Substrate bindingUniRule annotation
    Regioni254 – 2552Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    KOiK00254.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00225. DHO_dh_type2.
    InterProiIPR013785. Aldolase_TIM.
    IPR012135. Dihydroorotate_DH_1_2.
    IPR005719. Dihydroorotate_DH_2.
    IPR001295. Dihydroorotate_DH_CS.
    [Graphical view]
    PfamiPF01180. DHO_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000164. DHO_oxidase. 1 hit.
    TIGRFAMsiTIGR01036. pyrD_sub2. 1 hit.
    PROSITEiPS00911. DHODEHASE_1. 1 hit.
    PS00912. DHODEHASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F4GCB3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLLPYAFAR PFLFGMDAEA AHELTMDMLA RGQRTPLQWA WCNETVSDPV    50
    QLAGLTFPNR VGLAAGLDKN ARCIDALAAM GFGFVEVGTV TPKAQPGNPK 100
    PRMFRLPEAR ALINRLGFNN EGLDAFIANV RRSQVRAQGK PLLLGLNIGK 150
    NAATPIEQAT GDYLACLEGV YPHADYVTVN ISSPNTQNLR ALQSDEALDA 200
    LLGAIADHRE KLAAAQGRRV PIFVKIAPDL NEAQVAVIAA TLTRHGMDGV 250
    VATNTTIARD AVQGLPHAGE AGGLSGAPVR EASNAVIRQL RAALGPAFPI 300
    VGVGGVMSAE DAVGKIRAGA DVVQIYTGLI YEGPALVSRA ARAIRAMR 348
    Length:348
    Mass (Da):36,742
    Last modified:June 28, 2011 - v1
    Checksum:i843DD28148E780DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002657 Genomic DNA. Translation: AEB84772.1.
    RefSeqiWP_013519048.1. NC_015422.1.
    YP_004388288.1. NC_015422.1.

    Genome annotation databases

    EnsemblBacteriaiAEB84772; AEB84772; Alide2_2408.
    GeneIDi10483455.
    KEGGiadk:Alide2_2408.
    PATRICi54527494. VBIAliDen79014_2432.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002657 Genomic DNA. Translation: AEB84772.1 .
    RefSeqi WP_013519048.1. NC_015422.1.
    YP_004388288.1. NC_015422.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEB84772 ; AEB84772 ; Alide2_2408 .
    GeneIDi 10483455.
    KEGGi adk:Alide2_2408.
    PATRICi 54527494. VBIAliDen79014_2432.

    Phylogenomic databases

    KOi K00254.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00946 .
    BioCyci ADEN596154:GHU6-2439-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00225. DHO_dh_type2.
    InterProi IPR013785. Aldolase_TIM.
    IPR012135. Dihydroorotate_DH_1_2.
    IPR005719. Dihydroorotate_DH_2.
    IPR001295. Dihydroorotate_DH_CS.
    [Graphical view ]
    Pfami PF01180. DHO_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000164. DHO_oxidase. 1 hit.
    TIGRFAMsi TIGR01036. pyrD_sub2. 1 hit.
    PROSITEi PS00911. DHODEHASE_1. 1 hit.
    PS00912. DHODEHASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Alicycliphilus denitrificans K601."
      US DOE Joint Genome Institute
      Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Zeytun A., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mikhailova N., Pagani I., Oosterkamp M.
      , Pieper D., van Berkel W., Langenhoff A., Smidt H., Stams A., Woyke T.
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 14773 / CIP 107495 / K601Imported.

    Entry informationi

    Entry nameiF4GCB3_ALIDK
    AccessioniPrimary (citable) accession number: F4GCB3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3