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Protein

Phosphoenolpyruvate carboxylase

Gene

ppcA

Organism
Metallosphaera cuprina (strain Ar-4)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

BioCyciMCUP1006006:GHTI-1270-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcAUniRule annotation
Ordered Locus Names:Mcup_1246Imported
OrganismiMetallosphaera cuprina (strain Ar-4)Imported
Taxonomic identifieri1006006 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
ProteomesiUP000007812 Componenti: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi1006006.Mcup_1246.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 2 family.UniRule annotation

Phylogenomic databases

KOiK01595.
OMAiQSAFRYD.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

F4G3I1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLIPRTMST QHPDNAHLPE WVKDEVIEGD SEVLEAYYAF SNLGVHEVMW
60 70 80 90 100
DAEGKDVDTH VVRKLFSSFS EYFKNNVLGE DLFLTYRVPN PKIEGAERKV
110 120 130 140 150
FAETMESIPI TFDVAEKFYG RKVVPVFEVI LPFTTNAIDV ISVAKYYEKA
160 170 180 190 200
VAMEENIELY QGVYVKDLVG EIHPKRVEVI PLIEDKDSLL NTRSILEGYY
210 220 230 240 250
DAMKPTYMRL FIARSDPAMN YGMLTAVLLA KLALSTAYKF SREKGIQIFP
260 270 280 290 300
IIGVGSLPFR GHLSPENYQR VIEEYEGVYT YTVQSAFKYD YSEEQAKGAI
310 320 330 340 350
SHINKEEPRE PKVLTDEEEK TIRDIADKYT SSYQPVIEGM ADLINSIALY
360 370 380 390 400
LPRRRARKLH ISLFGYARST GKVILPRAIT FVGSLYSLGL PPEVIGVSVL
410 420 430 440 450
SDLTEREWKV LEENYKFMKN DLQKASEFIN IEAINSLVSH GFLSEDLSRR
460 470 480 490 500
IDEDIKYLES LGIKVGPRSY ESKKHALLSQ LAILSLKEKR LAEVKQYLKE

MAEIRRSVG
Length:509
Mass (Da):58,200
Last modified:June 28, 2011 - v1
Checksum:iB70FE5AA32CC11F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002656 Genomic DNA. Translation: AEB95351.1.
RefSeqiWP_013737849.1. NC_015435.1.
YP_004409835.1. NC_015435.1.

Genome annotation databases

EnsemblBacteriaiAEB95351; AEB95351; Mcup_1246.
GeneIDi10493437.
KEGGimcn:Mcup_1246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002656 Genomic DNA. Translation: AEB95351.1.
RefSeqiWP_013737849.1. NC_015435.1.
YP_004409835.1. NC_015435.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi1006006.Mcup_1246.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEB95351; AEB95351; Mcup_1246.
GeneIDi10493437.
KEGGimcn:Mcup_1246.

Phylogenomic databases

KOiK01595.
OMAiQSAFRYD.

Enzyme and pathway databases

BioCyciMCUP1006006:GHTI-1270-MONOMER.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Metallosphaera cuprina, a metal sulfide-oxidizing archaeon from a hot spring."
    Liu L.J., You X.Y., Zheng H., Wang S., Jiang C.Y., Liu S.J.
    J. Bacteriol. 193:3387-3388(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ar-4Imported.

Entry informationi

Entry nameiF4G3I1_METCR
AccessioniPrimary (citable) accession number: F4G3I1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: July 22, 2015
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.